KP-457

Name: KP-457
Brand: Adooq Bioscience
SKU: A19622
Rating: 5 (1 reviews)

Catalog No.: A19622

ADAM17 inhibitor

Adooq's KP-457 has been cited by 1 publications

KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC50s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively.

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Grouped product items
Size	Price	Stock
1mg	$85.00	In stock
5mg	$220.00	In stock
10mg	$365.00	In stock
25mg	$680.00	In stock
50mg	$1,085.00	In stock
100mg	$1,475.00	In stock
*10mM 1mL in DMSO**	$235.00	In stock
Bulk Size	Bulk Discount

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Adooq Products cited in reputable paper

Adooq's KP-457 has been cited by 1 publications

Tolulope E Ayo, .et al. , Cell Signal, 2023, May;105:110607 PMID: 36690134

Biological Activity

Description	KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC50s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively.

Product Information

Catalog Num	A19622
Formula	C21H24N2O7S2
Molecular Weight	480.55
CAS Number	1365803-52-6
SMILES	CS(=O)(NCC1=CC=C(C(N(C=O)O)CS(=O)(C2=CC=C(OCC#CC)C=C2)=O)C=C1)=O
Synonyms	KP457, KP 457
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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