MLN2238 (Ixazomib)

Catalog No.: A10600

Proteasome Inhibitor

MLN2238 (Ixazomib)

MLN2238 (Ixazomib) Chemical Structure

CAS NO. 1072833-77-2

MLN2238 is a potent reversible and specific β5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM.

Availability: In stock

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5 mg
10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Biological Activity

MLN2238 is a potent reversible and specific β5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM.
20S proteasome (Cell-free assay) 20S proteasome (Cell-free assay)
0.93 nM(Ki)3.4 nM
In vitro (25°C) DMSO 64 mg/mL (177.26 mM)
Water Insoluble
Ethanol 8 mg/mL (22.15 mM)
In vivo 5% DMSO+45% PEG 300+ddH2O 16 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.7 mL 138.5 mL 277.01 mL
0.5 mM 5.54 mL 27.7 mL 55.4 mL
1 mM 2.77 mL 13.85 mL 27.7 mL
5 mM 0.55 mL 2.77 mL 5.54 mL

*The above data is based on the productmolecular weight 361.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10600
Actions Inhibitor
CAS No. 1072833-77-2
Formula C14H19BCl2N2O4
M. Wt 361.0
Purity >98%
Synonyms MLN 2238, MLN-2238
SMILES B([[email protected]](CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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