MLN2238 (Ixazomib)

Catalog No.: A10600

Proteasome Inhibitor

MLN2238 (Ixazomib)

MLN2238 (Ixazomib) Chemical Structure

CAS NO. 1072833-77-2

MLN2238 is a potent reversible and specific β5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $90.00

Special Price $81.00

10 mg

Regular Price: $120.00

Special Price $108.00

50 mg

Regular Price: $350.00

Special Price $315.00

100 mg

Regular Price: $600.00

Special Price $540.00

10mM * 1mL in DMSO

Regular Price: $90.00

Special Price $81.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

MLN2238 is a potent reversible and specific β5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM.
Targets
20S proteasome (Cell-free assay) 20S proteasome (Cell-free assay)
0.93 nM(Ki)3.4 nM
In vitro (25°C) DMSO 72 mg/mL (199.42 mM)
Water <1 mg/mL (<1 mM)
Ethanol 9 mg/mL (24.92 mM)
In vivo 0.5% hydroxyethyl cellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.7 mL 138.5 mL 277.01 mL
0.5 mM 5.54 mL 27.7 mL 55.4 mL
1 mM 2.77 mL 13.85 mL 27.7 mL
5 mM 0.55 mL 2.77 mL 5.54 mL

*The above data is based on the productmolecular weight 361.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A10600
Actions Inhibitor
M. Wt 361.0
Formula C14H19BCl2N2O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1072833-77-2
Synonyms MLN 2238, MLN-2238
SMILES B([[email protected]](CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O

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