(R,S,R)-AHPC-NHBoc

Catalog No.: A80976
Ligand for E3 Ligase
(R,S,R)-AHPC-NHBoc is a ligand for the E3 ubiquitin ligase VHL that facilitates the recruitment of the VHL protein. This compound can be utilized to construct PROTACs by linking it to a target protein ligand through a suitable linker. Its ability to modulate protein degradation pathways makes it a valuable tool for research in targeted protein degradation and related therapeutic applications.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description(R,S,R)-AHPC-NHBoc is a ligand for the E3 ubiquitin ligase VHL that facilitates the recruitment of the VHL protein. This compound can be utilized to construct PROTACs by linking it to a target protein ligand through a suitable linker. Its ability to modulate protein degradation pathways makes it a valuable tool for research in targeted protein degradation and related therapeutic applications.
Product Information
Catalog NumA80976
FormulaC27H38N4O5S
Molecular Weight530.68
CAS Number1799506-31-2
SMILESC([C@H](NC(OC(C)(C)C)=O)[C@](C)(C)C)(=O)N1[C@@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@H](O)C1
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This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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