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CRBN ligand-443

Ligand for E3 Ligase

CRBN ligand-443 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the development of PROTAC (Proteolysis Targeting Chimeras) by linking it to a target protein ligand through a suitable linker. Its application in targeted protein degradation supports innovative research in therapeutic development and cellular regulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925069-79-8
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₁N₃O₃
Molecular Weight	257.25
SMILES	O=CC1=CC=2C=C(C=CC2N1)N3C(=O)NC(=O)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.