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Thalidomide-SH

Ligand for E3 Ligase

Thalidomide-SH is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of cereblon to target proteins, enabling targeted protein degradation through PROTAC technology. Thalidomide-SH serves as a versatile tool in chemical biology and drug discovery, offering potential applications in studying protein regulation and developing new therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2378582-97-7
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₀N₂O₄S
Molecular Weight	290.29
SMILES	O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3S)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.