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CRBN ligand-365

Ligand for E3 Ligase

CRBN ligand-365 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling targeted protein degradation via the ubiquitin-proteasome system. This compound serves as a crucial component for the development of PROTACs (Proteolysis Targeting Chimeras) by facilitating the recruitment of CRBN to a specific target protein. This functionality makes CRBN ligand-365 a valuable tool for investigating protein homeostasis and therapeutic interventions in various biological pathways and diseases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925088-31-7
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₂N₄O₂
Molecular Weight	256.27
SMILES	O=C1NC(=O)CCN1C2=CC=CC3=CN=C(N)C=C32

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.