Fig. 1 · Structure
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Thalidomide-4-Br,7-F
E3 Ligase Activator
Thalidomide-4-Br,7-F is an E3 ligase activator, containing both bromine and fluorine substituents. E3 ligases play a crucial role in the ubiquitin-proteasome system by tagging proteins for degradation, thereby regulating various cellular processes. This compound's halogen functional groups allow for potential further derivatization, making it a valuable tool for research in protein degradation pathways and targeted protein modulation. Its application extends to studies involving cancer biology, protein regulation, and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 2740657-30-9 |
| Applications | E3 Ligase Activator |
| Formula | C13H8BrFN2O4 |
| Molecular Weight | 355.12 |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C(F)=CC=C3Br)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.