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CRBN ligand-433

Ligand for E3 Ligase

CRBN ligand-433 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the CRBN protein, enabling the design of Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation. This compound is valuable for research applications focused on understanding cellular protein regulation and developing novel therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925093-44-1
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₁N₃O₃
Molecular Weight	257.25
SMILES	O=CC1=CC=2C=CNC2C(=C1)N3C(=O)NC(=O)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.