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CRBN ligand-308

Ligand for E3 Ligase

CRBN ligand-308 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be utilized to chemically link to a target protein ligand through a suitable linker, enabling the development of proteolysis-targeting chimeras (PROTACs). Its ability to modulate protein degradation pathways makes it a valuable tool for studying protein turnover and the therapeutic potential of targeted protein degradation in various biological contexts.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925095-92-5
Applications	Ligand for E3 Ligase
Formula	C₁₂H₁₁N₅O₂
Molecular Weight	257.25
SMILES	O=C1NC(=O)CCN1C=2C=C(N)C=3N=CN=CC3C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.