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CRBN ligand-578

Ligand for E3 Ligase

CRBN ligand-578 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It can be conjugated to target protein ligands through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). This compound is valuable for studies in targeted protein degradation and cellular protein modulation, making it useful in therapeutic research and drug development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925087-52-9
Applications	Ligand for E3 Ligase
Formula	C₁₂H₁₃N₅O₂
Molecular Weight	259.27
SMILES	O=C1NC(=O)CCN1C=2C=C(N)C=3C=NN(C3C2)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.