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CRBN ligand-457

Ligand for E3 Ligase

CRBN ligand-457 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound serves as a valuable tool for the development of PROTACs by linking CRBN to target protein ligands through a suitable linker. Its utility in targeted protein degradation research makes it an essential reagent for studies in drug discovery and cellular biology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925079-15-6
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₀N₄O₃
Molecular Weight	270.25
SMILES	O=CC=1C=C2N=CN=CC2=C(C1)N3C(=O)NC(=O)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.