Fig. 1 · Structure
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5-Hydroxy-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Thalidomide Analog
5-Hydroxy-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione is a Thalidomide analog that possesses a hydroxy group allowing for potential derivatization. This compound functions as an E3 ligase activator, facilitating the ubiquitinylation of target proteins. Its biological activity makes it valuable for research in drug development, particularly in studies focused on protein degradation and cellular signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 2589697-74-3 |
| Applications | Thalidomide Analog |
| Formula | C14H12N2O5 |
| Molecular Weight | 288.26 |
| SMILES | CN1C(CCC(C1=O)N2C(C3=C(C2=O)C=C(C=C3)O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.