Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.
Nef ligand-2 is a specific ligand for the Nef protein, functioning primarily as a binder that targets E3 ligases. It plays a crucial role in modulating protein interactions and degradation pathways, offering valuable insights into Nef-related signaling mechanisms. This compound is particularly relevant in research applications focused on HIV pathogenesis and the exploration of therapeutic strategies targeting E3 ligase activity.
Out of stock
All 3 sizes
WDR5 Degrader-1 is a cereblon (CRBN)-recruiting compound designed to selectively induce degradation of the WDR5 protein. This degrader effectively targets WDR5 while sparing the CRBN neo-substrate IKZF1, facilitating precise manipulation of WDR5 levels in cellular systems. It is a valuable tool for investigating the biological roles of WDR5 in transcriptional regulation and potential therapeutic strategies in diseases associated with dysregulated WDR5 expression.
IPS-06061 is a molecular glue degrader that targets the KRAS G12D mutant through the formation of a ternary complex with CRBN. This compound effectively degrades KRAS G12D with a DC50 value of less than 500 nM, demonstrating significant anti-tumor efficacy. It serves as a valuable tool for research into targeted therapies for cancers driven by KRAS mutations.
VHL-IN-1 is an inhibitor of the von Hippel-Lindau (VHL) ubiquitin E3 ligase with a dissociation constant (Kd) of 37 nM. It effectively stabilizes and enhances the transcriptional activity of HIF-1α, which plays a crucial role in cellular responses to hypoxia. VHL-IN-1 is potentially valuable in research applications aimed at exploring HIF-1α regulation and the development of proteolytically targeted chimeras (PROTACs) for targeted protein degradation.
Synonyms: Pebac; D-Phenylalanyl-prolyl-arginyl Chloromethyl Ketone; D-Phe-Pro-Arg-CH2Cl
PPACK dihydrochloride is a potent and selective irreversible inhibitor of thrombin. It serves as an alternative anticoagulant to lithium heparin for blood gas and electrolyte analyses in whole blood. Additionally, PPACK dihydrochloride inhibits plasminogen activator (rt-PA), preventing its binding to plasma protease inhibitors. This compound also reduces plasmin-induced endothelial permeability and morphological changes in bovine aortic endothelial cell monolayers, making it suitable for investigations in thrombosis-related research.
Lenalidomide 4'-PEG1-amine dihydrochloride serves as a ligand for E3 ligase, specifically targeting the Cereblon (CRBN) protein. This compound facilitates the recruitment of CRBN, enabling the development of proteolysis-targeting chimeras (PROTACs). Researchers can utilize this reagent to explore targeted protein degradation pathways and investigate potential therapeutic applications in various cancers and other diseases.
Lenalidomide 4'-PEG2-amine dihydrochloride is a Cereblon ligand that targets the CRBN protein, playing a crucial role in E3 ligase recruitment. This compound facilitates the development of PROTACs by linking to various target proteins through a suitable linker. It is valuable for research focused on regulated protein degradation pathways and the study of cellular processes influenced by E3 ligase activity.
(S,R,S)-AHPC-C2-PEG3-BCN is a ligand targeting E3 ligases, specifically the von Hippel-Lindau (VHL) E3 ligase. It plays a vital role in the synthesis of PROTACs (proteolysis-targeting chimeras), which mediate targeted degradation of proteins within cells. This compound is intended for research applications in protein degradation and cellular regulation studies.
Lenalidomide 4'-PEG3-amine dihydrochloride is a selective ligand for the E3 ubiquitin ligase Cereblon (CRBN). This compound facilitates the recruitment of CRBN, enabling targeted protein degradation through the PROTAC (Proteolysis Targeting Chimeras) mechanism. Its application includes the development of innovative therapeutic strategies for various diseases by harnessing the ubiquitin-proteasome system for regulated protein turnover.
Pomalidomide-5-C6-NH2 hydrochloride is a cereblon (CRBN) ligand derived from Pomalidomide. This compound functions by facilitating the recruitment of CRBN proteins, making it an essential tool for the development of PROTAC (Proteolysis Targeting Chimeras) constructs. Its ability to form linkages with target proteins through a linker enhances its utility in targeted protein degradation research, paving the way for innovative therapeutic strategies in various diseases.
Pomalidomide 4'-alkylC6-azide is a cereblon (CRBN) ligand that facilitates selective protein targeting via the recruitment of the CRBN protein. It serves as a key component in the development of PROTACs (Proteolysis Targeting Chimeras), enabling targeted degradation of specific proteins. This reagent is essential for research in targeted protein degradation and the modulation of cellular pathways critical for disease mechanisms.
Pomalidomide-C6-COOH is a cereblon (CRBN) ligand derived from pomalidomide, designed for the specific recruitment of CRBN proteins. This compound serves as a vital building block for the development of PROTACs by enabling the conjugation of CRBN with various proteins via a linker. Its utility in targeted protein degradation makes it a valuable reagent for research applications in cellular signaling and therapeutic interventions.
Pomalidomide-5-C8-NH2 hydrochloride is a CRBN ligand derived from Pomalidomide. This compound facilitates the recruitment of the cereblon (CRBN) protein, enabling the design of targeted protein degradation strategies. It can be conjugated with a suitable linker to create PROTACs, which are valuable tools in therapeutic applications for modulating protein levels in various biological contexts.
CRBN ligand-895-PEG2-N3 is a synthetic E3 ligase ligand-linker conjugate designed to facilitate the development of PROTACs. This compound plays a crucial role in the targeted degradation of proteins by linking to E3 ligases, enhancing the specificity and efficacy of degradation processes. It serves as a valuable tool for researchers investigating protein modulation and therapeutic applications in targeted protein degradation strategies.
Out of stock
All 3 sizes
E3 Ligase Ligand-linker Conjugate 195 is a conjugate that targets cereblon (CRBN) through its ligand component. This compound facilitates the development of Proteolysis Targeting Chimeras (PROTACs) by providing a functional linker necessary for targeted protein degradation. It is suitable for research applications investigating novel therapeutic strategies in protein modulation and degradation pathways.
Out of stock
All 3 sizes
VH032-C6-NH-Boc is a Boc-modified ligand that targets the von Hippel-Lindau (VHL) E3 ligase, facilitating the recruitment of VHL proteins. Under acidic conditions, it readily deprotection occurs, allowing its direct utilization in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as a crucial intermediate in developing PROTACs utilizing VHL ligands, thereby advancing research in targeted protein degradation.
Out of stock
All 3 sizes
(S,R,S)-AHPC-CO-C9-NH2 is a Von Hippel-Lindau (VHL) ligand that serves as a crucial building block for the synthesis of E3 ligase ligands utilized in the development of PROTACs (Proteolysis Targeting Chimeras). This compound enhances the understanding of protein degradation pathways and enables targeted protein modulation, making it a valuable tool for researchers investigating targeted therapies in cancer and other diseases.
Out of stock
All 3 sizes
Pomalidomide-C11-NH2 is a Pomalidomide derivative that functions as a ligand for the E3 ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN protein, enabling targeted protein degradation applications through PROTAC technology. Its utility in the development of targeted therapeutics offers significant potential for advancing cancer research and treatment strategies.
Out of stock
All 3 sizes
Pomalidomide-5-C5-NH2 hydrochloride is a cereblon (CRBN) ligand derived from Pomalidomide, designed to facilitate the recruitment of the CRBN protein. This compound serves as a crucial component for the development of PROTACs that promote targeted protein degradation. Its unique structural modifications enhance its ability to engage with CRBN, enabling innovative research into therapeutic applications in cancer and other diseases.
CDLI-5 is a cereblon (CRBN) degrader-linker conjugate designed for the synthesis of cereblon degrader antibody conjugates (cDACs). This compound enables targeted protein degradation through the recruitment of E3 ligases to specific substrates, facilitating effective modulation of protein levels. CDLI-5 serves as a valuable tool in research applications focused on targeted therapies and the development of novel anticancer strategies.
Out of stock
All 3 sizes
VH032-C2-NH-Boc is a Boc-modified ligand targeting the von Hippel-Lindau (VHL) E3 ligase, facilitating the recruitment of VHL proteins. Upon exposure to acidic conditions, it readily removes the protecting group, enabling its application in the direct synthesis of PROTAC molecules. This compound serves as an essential intermediate in developing PROTACs that utilize VHL ligands, offering valuable utility in targeted protein degradation research.
Out of stock
All 3 sizes
VH032-C3-Boc is a Boc-modified derivative of VH032, functioning as a ligand for the E3 ligase von Hippel-Lindau (VHL). Under acidic conditions, VH032-C3-Boc enables the removal of the protective group, facilitating direct utilization in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as an essential intermediate for developing VHL-based PROTACs, contributing to advancements in targeted protein degradation research.
Out of stock
All 3 sizes
Synonyms: β-NF-CH2-OH
β-Naphthoflavone-CH2-OH is a selective ligand for the arylhydrocarbon receptor (AhR) E3 ligase. This compound serves as a critical component in the design of targeted protein degradation strategies, such as PROTACs and SNIPERs, by linking to specific protein ligands to facilitate the recruitment of the AhR E3 ligase complex. Its ability to induce ubiquitination-mediated degradation of oncoproteins makes it a valuable tool in cancer research and drug discovery.
Out of stock
All 3 sizes
CRBN ligand-8-O-C6-NH2 is an E3 ligase ligand-linker conjugate that targets the cereblon (CRBN) E3 ubiquitin ligase, facilitating targeted protein degradation. This compound serves as a critical component in the synthesis of PROTAC ERα Degrader-11, thus aiding in the study of estrogen receptor-alpha (ERα) modulation and its associated cellular pathways. Researchers can utilize CRBN ligand-8-O-C6-NH2 for advancing the development of targeted therapeutic strategies in cancer and other diseases influenced by ERα signaling.
Out of stock
All 3 sizes
Synonyms: (S,R,S)-AHPC-PEG6-NH2 hydrochloride
VH 032 amide-PEG6-amine hydrochloride is a functionalized ligand for the von Hippel-Lindau (VHL) E3 ligase, specifically designed for PROTAC (Proteolysis Targeting Chimera) development. This compound features an E3 ligase ligand conjugated to a PEG6 moiety, facilitating the incorporation of terminal amines for coupling with target protein ligands. VH 032 amide-PEG6-amine hydrochloride is essential for advancing research in targeted protein degradation and drug development strategies.
