Catalog No.
Product Name
Application
Product Information
Citations
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Hydrophobic Tag
5-Norbornene-2-methylamine is a hydrophobic tag utilized in the synthesis of targeted protein degraders. As an E3 ligase ligand, it facilitates the construction of PROTAC molecules, including PROTAC PARP1 degrader-4. This compound is essential for advancing research in protein degradation and its applications in therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-880 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the design of PROTACs (proteolysis-targeting chimeras) by linking it to a ligand that binds a specific target protein, enabling targeted protein degradation. Its application in chemical biology research includes elucidating protein function and modulating cellular pathways through controlled degradation mechanisms. -
Ligands for E3 Ligase
CRBN ligand-109 is a selective ligand for the CRBN E3 ubiquitin ligase, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound can effectively promote the ubiquitination and subsequent degradation of target proteins, making it a valuable tool in the study of protein regulation and degradation pathways. Its application is critical in drug discovery, particularly in targeting disease-associated proteins for therapeutic intervention. -
Cereblon Modulator
CC-3060 is a Cereblon modulator that facilitates the degradation of ZBTB16, showing a DC50 value of 0.47 nM in HT-1080 cells. This compound engages specific structural degrons across various zinc finger domains, effectively promoting ZBTB16's proteasomal degradation. CC-3060 has potential applications in the study of cellular processes regulated by ZBTB16 and in the development of innovative therapeutic strategies targeting this pathway. -
Ligands for E3 Ligase
Lenalidomide-Br is an analog of the cereblon (CRBN) ligand Lenalidomide, functioning as a ligand for the E3 ubiquitin ligase. This compound effectively recruits the CRBN protein, facilitating targeted protein degradation. Lenalidomide-Br can be utilized to create PROTACs, such as the PROTAC STAT3 degrader SD-36, expanding its application in studies focused on targeted therapy and protein modulation in various biological contexts. -
RNF4 Ligand
CCW16 is a ligand for RNF4, facilitating the synthesis of targeted protein degraders. It serves as a crucial cofactor in the development of PROTACs, such as CCW 28-3, by enhancing the ubiquitination process that promotes protein degradation. This reagent is essential for research involving protein homeostasis and therapeutic development using protein degradation strategies. -
Ligand for E3 Ligase
CRBN ligand-881 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the construction of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. CRBN ligand-881 is essential for studies involving targeted protein degradation, making it a valuable tool in drug discovery and development research. -
Ligands for E3 Ligase
DCAF1 binder 1 is a selective ligand for the CRL4 DCAF1 E3 ligase complex. This compound plays a crucial role in targeted protein degradation (TPD), making it valuable for research applications focused on modulating protein levels and understanding the mechanisms of E3 ligase activity. DCAF1 binder 1 can facilitate investigations into the therapeutic potential of TPD in various disease contexts. -
Protein Ligand
VH 101, acid is a functionalized von-Hippel-Lindau (VHL) protein ligand designed for PROTAC (proteolysis-targeting chimera) research and development. This compound features an E3 ligase ligand along with an alkyl linker equipped with a terminal amine, facilitating conjugation to a target protein ligand. VH 101, acid offers key applications in targeted protein degradation studies, providing insights into therapeutic interventions in various diseases. -
Ligand for E3 Ligase
5,6-Difluoro-desamino lenalidomide is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein to target proteins. This compound serves as a critical building block in the design of PROTACs (proteolysis-targeting chimeras) that harness the ubiquitin-proteasome system for targeted protein degradation. Its unique properties make it valuable for investigating protein modulation and therapeutic strategies in various biological contexts. -
Ligands for E3 Ligase
Lenalidomide-5-Br is a derivative of Lenalidomide that functions as a ligand for cereblon (CRBN), an E3 ubiquitin ligase. This compound effectively recruits CRBN to target proteins for ubiquitination and degradation, facilitating the development of Proteolysis Targeting Chimeras (PROTACs). Lenalidomide-5-Br is utilized in research focused on targeted protein degradation and therapeutic development for various diseases, including cancers and autoimmune disorders. -
Lenalidomide Analog
3-(6-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione is an analog of Lenalidomide that functions by recruiting the cereblon (CRBN) protein. This compound is primarily utilized in PROTAC (Proteolysis Targeting Chimera) research, enabling targeted degradation of specific proteins to elucidate their biological roles and potential therapeutic avenues. Its unique structure and mechanism make it a valuable tool for advancing studies in drug discovery and targeted therapies. -
Ligands for E3 Ligase
Lenalidomide-I is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the CRBN protein, making it a valuable component for the development of PROTACs (Proteolysis Targeting Chimeras). Applications of Lenalidomide-I include the creation of novel PROTACs, such as the PROTAC BET degrader QCA570, which are utilized in targeted protein degradation research. -
VHL Ligand
(S,R,S)-AHPC-propargyl is a VHL ligand that serves as a crucial component in the development of PROTACs through its role in "click reactions." This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its versatility makes it valuable for drug discovery and chemical biology applications, particularly in the creation of targeted protein degradation strategies. -
Ligands for E3 Ligase
E3 Ligase Ligand 64 functions as a ligand for E3 ligase, enabling its application in targeted protein degradation studies. This compound is instrumental in the synthesis of RP03707, facilitating research in ubiquitin-proteasome pathways and related signaling mechanisms. Its use enhances understanding of E3 ligase activity, making it significant for investigations into disease-related protein dysregulation. -
VHL Building Block
(S,S,S)-AHPC hydrochloride is a von Hippel-Lindau (VHL) amino building block that serves as a negative control for the (S,R,S)-AHPC compound. This compound is instrumental in studies involving VHL-mediated recruitment of the VHL protein, specifically in the context of targeted therapy and molecular interaction research. Its application extends to investigations requiring a controlled comparison against VHL ligands, providing a vital tool for biochemical analysis. -
Ligands for E3 Ligase
(S,R,S)-AHPC-Boc is a ligand that selectively targets the von Hippel-Lindau (VHL) protein, facilitating the recruitment of this E3 ligase. This compound is integral to the development of Proteolysis Targeting Chimeras (PROTACs), enabling the selective degradation of target proteins in cellular systems. Its utility in research applications includes studying protein homeostasis and exploring therapeutic strategies for various diseases. -
Ligands for E3 Ligase
CRBN ligand-13 acts as a ligand for the CRBN-type E3 ubiquitin ligase, facilitating targeted protein degradation via the PROTAC (Proteolysis Targeting Chimeras) approach. It plays a critical role in the development of novel therapeutic strategies for various diseases by enabling the selective elimination of specific proteins within cells. This compound is valuable for researchers focused on protein regulation and targeted drug development. -
Cereblon Ligand
PD 4'-oxyacetic acid is a carboxylic acid-functionalized ligand for cereblon, a critical component in the development of PROTAC (Proteolysis Targeting Chimeras) degraders. This compound facilitates targeted protein degradation, making it valuable for research applications focused on protein homeostasis and therapeutic intervention in cancer and other diseases. Its ability to engage with the cereblon E3 ubiquitin ligase complex enhances the potential for novel therapeutic strategies in drug discovery. -
Ligands For E3 Ligase
Lenalidomide-OH is a potent analog of the cereblon (CRBN) ligand Lenalidomide, designed to selectively engage E3 ubiquitin ligase. This compound facilitates the recruitment of CRBN protein, essential for targeted protein degradation applications. Lenalidomide-OH can be coupled with various ligands via a linker to construct PROTACs, such as the BTK degrader SJF620, making it a valuable tool in studies of protein homeostasis and therapeutic development. -
Ligands for E3 Ligase
N-Me-Thalidomide 4-fluoride is a ligand for E3 ligase, functioning as a tool in targeted protein degradation studies. It plays a critical role in the synthesis of Anti-inflammatory agent 70, which has potential applications in modulating inflammatory pathways. This compound is of significant interest for researchers investigating therapeutic strategies that harness E3 ligase activity in various biological contexts.
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Ligands for E3 Ligase
5-Aminothalidomide is an E3 ligase ligand that plays a crucial role in PROTAC technology. This compound facilitates the synthesis of targeted protein degraders, enabling the development of specific PROTACs such as BRD9 Degrader-7. Its ability to modulate protein levels provides valuable insights into proteostasis and therapeutic intervention in various biological studies. -
Ligands for E3 Ligase
3-(4-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a ligand for the E3 ligase cereblon (CRBN). This compound enables the targeted recruitment of CRBN, facilitating the degradation of specific proteins through the formation of proteolysis-targeting chimeras (PROTACs). It is a valuable tool for studying protein homeostasis and exploring therapeutic strategies in various diseases, including cancer. -
Ligand for E3 Ligase
CRBN ligand-397 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be connected to a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. Its utility in research includes the development of innovative therapeutic strategies that exploit the ubiquitin-proteasome system. -
Ligand for E3 Ligase
(S,R,S)-AHPC-Me-NHBoc is a selective ligand for the E3 ubiquitin ligase von Hippel-Lindau (VHL), facilitating the recruitment of the VHL protein to target substrates. This compound can be conjugated with target protein ligands through a linker to create an effective PROTAC (Proteolysis Targeting Chimera). Its unique properties make it a valuable tool in the study of targeted protein degradation and related biological pathways. -
Ligand for E3 Ligase
5-Br-6-F-Desamino lenalidomide is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand using a linker, enabling the formation of a PROTAC (proteolysis-targeting chimeras). Its application in targeted protein degradation research offers significant potential for therapeutic intervention in various diseases. -
DCAF15 Ligand
DCAF15 ligand-1 is a selective ligand for the E3 ubiquitin ligase DCAF15, facilitating its role in substrate recognition and ubiquitination processes. This compound is pivotal in biochemical studies aimed at understanding the mechanistic pathways involving DCAF15-mediated protein degradation. Additionally, DCAF15 ligand-1 can be utilized in the synthesis of associated compounds, such as IBG1, enhancing its relevance in research applications focused on targeted protein modulation. -
Ligands for E3 Ligase
KB02-COOH is a chemical compound that serves as a ligand for E3 ligase, playing a crucial role in the ubiquitin-proteasome system. This fragment is essential for the synthesis of proteolysis-targeting chimeras (PROTACs), including variants such as KB02-JQ1 and KB02-SLF. Researchers can utilize KB02-COOH in studies focused on targeted protein degradation and the modulation of protein activity within cellular pathways. -
Ligand for E3 Ligase
Desamino lenalidomide-6-COOH is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker, enabling the development of a PROTAC (Proteolysis Targeting Chimeras). Desamino lenalidomide-6-COOH is essential for research in targeted protein degradation and has potential applications in drug discovery and therapeutic interventions. -
Ligand for E3 Ligase
Desamino lenalidomide-CH2NH2 hydrochloride functions as a ligand for the E3 ubiquitin ligase protein cereblon (CRBN). This compound is instrumental in the targeted recruitment of cereblon, facilitating the development of protein-targeted degradation strategies. It can be conjugated with a target protein ligand through a suitable linker to create a proteolysis-targeting chimera (PROTAC), thereby advancing research in protein degradation and targeted therapies. -
Ligand for E3 Ligase
CRBN ligand-734 is a potent ligand for the E3 ubiquitin ligase, cereblon (CRBN). This compound facilitates the recruitment of CRBN, enabling targeted protein degradation through the formation of PROTAC (proteolysis-targeting chimeras) by linking it with a target protein ligand via a suitable linker. Its utility is significant in studies focusing on targeted therapy and protein regulation mechanisms in various biological contexts. -
E3 Ligase Ligand
E3 ligase Ligand PG is a selective ligand targeting the CRBN E3 ubiquitin ligase, exhibiting strong binding affinity with an IC50 of 2.191 μM. This compound is suitable for applications involving the recruitment of the CRBN protein, facilitating the development of proteolysis-targeting chimeras (PROTACs). E3 ligase Ligand PG can be utilized in conjunction with BMS-202 to form PROTAC PD-L1 degrader-1, enabling targeted degradation of specific proteins for therapeutic research purposes. -
Ligands for E3 Ligase
(S,R,S)-AHPC-Me dihydrochloride targets the von Hippel-Lindau (VHL) protein as a ligand for E3 ligase recruitment. This compound serves as a critical precursor for the synthesis of ARV-771, a PROTAC degrader that utilizes the VHL E3 ligase to facilitate the degradation of BET proteins. It has demonstrated potent activity in degrading BET proteins in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM, highlighting its potential for therapeutic applications in cancer research. -
Ligand for E3 Ligase
Desamino lenalidomide-5-F is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), essential for directing protein degradation via the ubiquitin-proteasome system. This compound facilitates the recruitment of cereblon and can be utilized to create PROTACs by conjugating it to target protein ligands through a linker. Desamino lenalidomide-5-F is instrumental in studies focusing on targeted protein degradation and the exploration of novel therapeutic strategies in various diseases. -
Lenalidomide Analog
3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione functions as a Lenalidomide analog with potential utility in targeted protein degradation research. This compound exhibits properties that may facilitate the design of proteolysis-targeting chimeras (PROTACs), thereby enabling the selective degradation of proteins of interest. Further investigation into its biological activity could contribute to advancements in therapeutic strategies aimed at modulating cellular proteostasis and addressing various diseases. -
Ligand for E3 Ligase
CRBN ligand-798 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It can be conjugated to a target protein ligand via a linker to create a proteolysis-targeting chimera (PROTAC). This compound is valuable for research applications focused on targeted protein degradation and the modulation of cellular pathways involving CRBN. -
Ligand for E3 Ligase
Pomalidomide-5-OH (5-hydroxy pomalidomide) serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN protein. This compound can be utilized in the synthesis of PROTACs by linking it to other ligands, enabling targeted protein degradation. Its applications in chemical biology and drug discovery make it an essential tool for researchers investigating proteostasis and therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-394 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound is instrumental in the development of PROTACs by enabling the conjugation of target protein ligands through a linker. Its utility extends to studies in targeted protein degradation and therapeutic applications. -
VHL Ligand
VHL Ligand 14 is a specific ligand for the von Hippel-Lindau (VHL) protein, playing a crucial role in the development of PROTACs that target estrogen receptor α (ERα) for degradation. With a binding affinity of 196 nM, it facilitates the targeted ubiquitination and subsequent proteasomal degradation of ERα. This compound is primarily utilized in research applications focused on cancer biology and targeted protein degradation strategies. -
Ligand for E3 Ligase
Lenalidomide 5'-piperazine hydrochloride is a ligand for the E3 ubiquitin ligase Cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling the development of proteolysis-targeting chimera (PROTAC) molecules for targeted protein degradation. This compound is particularly useful in research focused on modulating protein levels in cellular pathways, contributing to the study of various diseases and therapeutic interventions. -
Isomer
(S,S,S)-AHPC-Boc is a stereoisomer of (S,R,S)-AHPC-Boc and serves as a valuable experimental control in research. This compound specifically relates to the recruitment of the von Hippel-Lindau (VHL) protein, which plays a critical role in targeted protein degradation through PROTAC technology. By providing a reliable reference point, (S,S,S)-AHPC-Boc facilitates investigations into the efficacy and selectivity of VHL ligands in cellular systems. -
Ligands for E3 Ligase
Lenalidomide-6-F is a modified derivative of Lenalidomide that functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound effectively recruits CRBN, facilitating the targeted degradation of specific proteins via the PROTAC (proteolysis-targeting chimera) mechanism. Lenalidomide-6-F is valuable for research applications focused on the modulation of cellular protein levels and the development of novel therapeutic strategies in cancer and other diseases. -
CRBN Ligand
2-Methoxyphenyl dihydrouracil serves as a ligand for the cereblon (CRBN) protein, enhancing its interaction in targeted protein degradation assays. This compound is valuable for the development of PROTACs (Proteolysis Targeting Chimeras), facilitating studies in targeted therapy and protein regulation. Its applications extend to research focused on modulating protein levels and understanding ubiquitin-proteasome system mechanisms. -
Ligand for E3 Ligase
Hydrouracil-3-Ph-COOH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in biochemical applications. This compound is designed to be employed in the development of proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands through a suitable linker, making it valuable in targeted protein degradation research. Its utility in creating complex biologics underscores its significance in advancing studies of protein modulation and therapeutic strategies. -
Ligand for E3 Ligase
CC-17369 (7-Hydroxy pomalidomide) serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound, a metabolite of Pomalidomide, selectively recruits CRBN, making it a valuable tool in targeted protein degradation studies. CC-17369 can be conjugated to other ligands via a linker to create PROTACs, facilitating research into novel therapeutic strategies for diseases involving protein dysregulation. -
Mdm2 E3 Ligase Inhibitor
MEL24 is an inhibitor of the Mdm2 E3 ligase, which plays a critical role in regulating p53 protein levels. This compound significantly reduces cell survival and enhances sensitivity to DNA-damaging agents in a p53-dependent manner. MEL24 is primarily utilized in antitumor research, contributing to studies aimed at understanding and overcoming resistance in cancer therapies. -
Ligands for E3 Ligase
Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride is an E3 ligase ligand designed for PROTAC (proteolysis-targeting chimera) development. This compound serves as a protein degrader, featuring a terminal piperidine that facilitates further chemical modifications. Its unique structure allows for enhanced interaction with target proteins, making it a valuable tool for studying targeted protein degradation in various research applications. -
Ligand for E3 Ligase
CRBN ligand-660 is a ligand targeting the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to construct a proteolysis-targeting chimera (PROTAC), making it useful in studies involving targeted protein degradation and cellular protein modulation. Its application in research enables the exploration of new therapeutic strategies by harnessing the ubiquitin-proteasome system. -
Thalidomide Analog
Thalidomide acid is a Thalidomide analog that primarily functions as a target for Proteolysis Targeting Chimeras (PROTACs). It exhibits significant activity in modulating protein degradation and is utilized in chemical biology studies aimed at elucidating proteostasis and targeted therapeutics. This compound serves as a valuable tool in drug discovery and development, particularly for diseases related to dysregulated protein levels. -
Thalidomide Analog
2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione is a Thalidomide analog primarily engaged in protein degradation pathways through PROTAC technology. Exhibiting modulatory effects on the immune system and anti-angiogenic properties, this compound is instrumental in investigational studies targeting multiple myeloma and other malignancies. Its distinctive structural attributes facilitate the exploration of targeted therapies and the development of innovative drug delivery platforms.
