Fig. 1 · Structure
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Lenalidomide-5-Br
Ligands for E3 Ligase
Lenalidomide-5-Br is a derivative of Lenalidomide that functions as a ligand for cereblon (CRBN), an E3 ubiquitin ligase. This compound effectively recruits CRBN to target proteins for ubiquitination and degradation, facilitating the development of Proteolysis Targeting Chimeras (PROTACs). Lenalidomide-5-Br is utilized in research focused on targeted protein degradation and therapeutic development for various diseases, including cancers and autoimmune disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1010100-26-1 |
| Applications | Ligands for E3 Ligase |
| Formula | C13H11BrN2O3 |
| Molecular Weight | 323.15 |
| SMILES | O=C(C(N(CC1=C2C=CC(Br)=C1)C2=O)CC3)NC3=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.