Catalog No.
Product Name
Application
Product Information
Citations
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Ligand for E3 Ligase
CRBN ligand-297 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a suitable linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-297 is crucial for studies involving targeted protein degradation and therapeutic development in various diseases, including cancer. -
Ligand for E3 Ligase
Desamino lenalidomide-5-F-4-CH2NH2 hydrochloride is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera), enabling targeted proteasomal degradation of specific proteins. Its application in protein degradation studies holds significant potential for advancing therapeutic strategies in various disease models. -
Ligand for E3 Ligase
CRBN ligand-435 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound serves as a key component in the development of PROTACs (proteolysis-targeting chimeras), allowing for targeted degradation of specific proteins in cellular assays. Its utility spans various research applications, including drug discovery and the study of protein homeostasis and degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-294 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the development of PROTACs (Proteolysis Targeting Chimeras) by linking it to a specific target protein ligand through a suitable linker. Its application in targeted protein degradation offers potential for advancing therapeutic strategies in various diseases. -
Ligand for E3 Ligase
CRBN ligand-668 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating its recruitment to target proteins. This compound can be conjugated to a specific target protein ligand through a linker, enabling the creation of a PROTAC (proteolysis targeting chimera). CRBN ligand-668 is essential for studies in targeted protein degradation and has potential applications in therapeutic development for various diseases. -
Ligand for E3 Ligase
CRBN ligand-669 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be effectively utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand via a suitable linker. Its application supports research in targeted protein degradation, offering a promising approach for therapeutic intervention in various diseases. -
Ligand for E3 Ligase
CRBN ligand-692 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. Its use is critical in the study of protein turnover and has applications in drug discovery and development for therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-737 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera). Its strategic design allows for targeted degradation of specific proteins, making it valuable in studies of protein homeostasis and novel therapeutic applications in various diseases. -
Ligand for E3 Ligase
CRBN ligand-364 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein in cellular contexts. This compound is designed to be conjugated to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera), enabling targeted protein degradation. CRBN ligand-364 is valuable for research in protein regulation and therapeutic applications in cancer and other diseases. -
Ligand for E3 Ligase
Desamino lenalidomide-4-Br-6-acetonitrile is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon to target proteins. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by connecting it to a target protein ligand through a suitable linker. Its application in targeted protein degradation research contributes to innovative therapeutic strategies in oncology and other areas of drug development. -
Ligand for E3 Ligase
CRBN ligand-640 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the development of PROTACs (Proteolysis Targeting Chimeras) for targeted protein degradation studies. Its utility in the modulation of protein levels presents valuable applications in drug discovery and therapeutic research. -
Ligand for E3 Ligase
CRBN ligand-257 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed for the development of PROTACs by linking to target protein ligands through a suitable linker, promoting targeted protein degradation. Its application in research is valuable for studying protein turnover and the modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN Ligand-344 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, enabling the development of PROTACs (proteolysis targeting chimeras). CRBN Ligand-344 is instrumental in targeted protein degradation research, providing valuable insights into protein regulation and therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-770 is a novel ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. By linking CRBN ligand-770 to a target protein ligand through a suitable linker, researchers can construct proteolysis-targeting chimeras (PROTACs). This compound is valuable for investigating targeted protein degradation pathways and therapeutic strategies in cellular models. -
Ligand for E3 Ligase
CRBN ligand-342 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of CRBN to target proteins. This compound is designed for use in the development of PROTACs (Proteolysis Targeting Chimeras), enabling the targeted degradation of specific proteins through ubiquitination. Its application in research enhances studies in protein homeostasis and targeted therapy development. -
Ligand for E3 Ligase
CRBN ligand-562 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of CRBN to target proteins. This compound serves as a crucial component in the design of proteolysis-targeting chimeras (PROTACs) by linking CRBN to specific target protein ligands through a suitable linker. It is useful in studies focused on targeted protein degradation and insights into cellular protein regulation mechanisms. -
Ligand for E3 Ligase
CRBN ligand-374 serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC. It offers a valuable tool for researchers studying protein degradation pathways and therapeutic applications in cellular regulation. -
Ligand for E3 Ligase
CRBN ligand-684 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, facilitating the formation of a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-684 is invaluable for research in targeted protein degradation and therapeutic interventions in diseases associated with dysregulated protein levels. -
Ligand for E3 Ligase
CRBN ligand-485 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound is utilized in the development of PROTACs (Proteolysis Targeting Chimeras) by linking to target protein ligands through a linker. Its primary application lies in targeted protein degradation research, enabling the modulation of specific protein levels in cellular systems for therapeutic investigations. -
Thalidomide Analog
5-Hydrazinyl thalidomide hydrochloride is a thalidomide analog that incorporates a hydrazine moiety, facilitating the development of PROTACs that target E3 ligases for the ubiquitination of specific proteins. This compound serves as a versatile intermediate, offering potential for further derivatization through reactions with a variety of carbonyl groups. Its application in chemical biology research holds promise for advancing therapeutic strategies targeting protein degradation pathways. -
Ligands for E3 Ligase
CRBN ligand-108 is an E3 ubiquitin ligase ligand that targets the cereblon (CRBN) component of the CRL4 E3 ligase complex. This compound facilitates the recruitment of target proteins for ubiquitination and subsequent degradation via the proteasome. CRBN ligand-108 is particularly valuable in the development of PROTACs (proteolysis-targeting chimeras) for targeted protein degradation research applications. Its utility extends to exploring therapeutic strategies in cancer and other diseases by modulating protein levels. -
Ligand for E3 Ligase
CRBN ligand-760 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating its recruitment in cellular processes. This compound is instrumental in the development of proteolysis-targeting chimeras (PROTACs) by conjugating with target protein ligands through a linker. Its application in targeted protein degradation studies provides valuable insights into cellular regulation and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-480 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound serves as a critical component in the development of PROTACs (proteolysis-targeting chimeras), where it can be connected to a target protein ligand through a linker. Its utility in research includes the study of targeted protein degradation and the modulation of cellular signaling pathways. -
Ligand for E3 Ligase
CRBN ligand-260 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be connected to a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimeras). It is designed for applications in targeted protein degradation research, offering a unique approach to modulate protein levels in various biological contexts. -
Ligand for E3 Ligase
(S,R,S)-AHPC-amide-C10-azide is a potent ligand for the E3 ubiquitin ligase VHL, facilitating the recruitment of the VHL protein. This compound can be conjugated to target protein ligands through a linker, enabling the development of PROTACs for targeted protein degradation studies. Its unique structure and functionality make it a valuable tool for researchers investigating ubiquitin-proteasome pathways and exploring novel therapeutics in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-870 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the CRBN protein. This compound can be utilized in the design of PROTACs (proteolysis-targeting chimeras) by linking it to target protein ligands via a suitable linker. CRBN ligand-870 is instrumental in studying the targeted degradation of specific proteins, contributing to advancements in therapeutic strategies and research in cellular regulation. -
Ligand for E3 Ligase
CRBN ligand-550 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras). It serves as a valuable tool for studying protein degradation pathways and modulating cellular processes in research applications related to targeted protein degradation. -
Ligand for E3 Ligase
CRBN ligand-767 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed for use in the development of proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands through a suitable linker. Its application in drug discovery includes the targeted degradation of specific proteins, enabling innovative approaches to modulate protein activity in various biological studies. -
Ligand for E3 Ligase
CRBN ligand-569 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker to construct a proteolysis-targeting chimera (PROTAC). Its utility in drug discovery includes the potential for targeted protein degradation and modulation of cellular pathways, making it a valuable tool for researchers studying ubiquitin-proteasome system functionalities. -
Ligand for E3 Ligase
CRBN ligand-287 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound is designed for use in the development of proteolysis-targeting chimeras (PROTACs), enabling targeted degradation of proteins for therapeutic applications. Its ability to effectively modulate protein levels highlights its potential in various biological research and drug discovery endeavors. -
Ligand for E3 Ligase
CRBN ligand-232 is a ligand for the E3 ubiquitin ligase cerberlon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker to produce a PROTAC, enabling targeted protein degradation. Its application is particularly relevant in studies focusing on protein modulation and therapeutic intervention in various disease models. -
Ligand for E3 Ligase
(R,R,S)-AHPC is a ligand for the E3 ligase von Hippel-Lindau (VHL). This compound is designed to recruit the VHL protein, facilitating the degradation of target proteins through the formation of PROTACs (Proteolysis Targeting Chimeras). By linking (R,R,S)-AHPC to specific target protein ligands, researchers can effectively study protein regulation and explore novel therapeutic strategies in cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-667 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for targeted protein degradation. When conjugated with a specific target protein ligand through a linker, CRBN ligand-667 can be utilized to construct a PROTAC, enabling controlled degradation of the target protein. This compound is valuable for research applications focused on protein homeostasis, cellular regulation, and therapeutic development in oncology and other diseases. -
Ligand for E3 Ligase
CRBN ligand-292 is a small-molecule ligand that targets the E3 ubiquitin ligase cereblon (CRBN). It plays a crucial role in the recruitment of CRBN to target proteins, facilitating the formation of PROTACs (Proteolysis Targeting Chimeras). This compound is essential for drug discovery and cellular biology research, particularly in studies focused on targeted protein degradation and the modulation of protein function. -
Ligand for E3 Ligase
CRBN ligand-475 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to target-specific ligands through a linker to create proteolysis-targeting chimeras (PROTACs). CRBN ligand-475 is valuable for investigating targeted protein degradation and enhancing understanding of cellular mechanisms involved in disease pathways. -
Ligand for E3 Ligase
CRBN ligand-691 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN). It plays a crucial role in recruiting the CRBN protein, facilitating its interactions with target proteins. This ligand can be conjugated to a target protein via a linker to create a PROTAC, which supports targeted protein degradation applications in various areas of biological research. -
Ligand for E3 Ligase
CRBN ligand-501 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the CRBN protein. This compound can be conjugated with target protein ligands through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). Its application extends to the selective degradation of target proteins, making it a valuable tool in drug discovery and therapeutic research. -
Ligand for E3 Ligase
CRBN ligand-584 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein for targeted protein degradation. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC), which enables the selective degradation of specific proteins of interest. It serves as a valuable tool in chemical biology for the study of protein function and the development of innovative therapeutic strategies. -
E3 Ligase Ligand of PROTAC
CRBN ligand-896 is an E3 ligase ligand utilized in the development of PROTAC (Proteolysis Targeting Chimera) compounds. This reagent facilitates targeted protein degradation by enabling the selective ubiquitination of the epigenetic coactivator p300. It serves as a valuable tool in the investigation of protein regulation and therapeutic strategies in cancer and other diseases associated with dysregulated epigenetic modifiers. -
CRBN Modulator
ZXH-1-161 is a selective modulator of cereblon (CRBN) that induces the degradation of GSPT1 in a CRBN-dependent manner. This compound effectively inhibits the proliferation of multiple myeloma cells and demonstrates significant antitumor activity. Its unique mechanism of action makes it a valuable tool for investigating CRBN-targeted therapies in cancer research. -
Ligands for E3 Ligase
Pomalidomide 4'-PEG5-azide is a Pomalidomide-derived ligand specifically targeting the cereblon (CRBN) protein. This compound facilitates the recruitment of CRBN, making it a valuable tool in the development of PROTACs by linking to proteins through a suitable linker. Its application in chemical biology research enhances understanding of protein degradation pathways and E3 ligase modulation. -
Ligand For E3 Ligase
E3 ligase Ligand 79 serves as a ligand for the CRBN E3 ligase, facilitating the development of targeted protein degradation strategies. This compound is crucial for the synthesis of PROTAC CDK2/4 Degrader-1, which allows for selective degradation of protein targets in various biological contexts. Researchers can utilize this ligand to study the mechanisms of E3 ligase-mediated degradation and its potential therapeutic applications. -
Cereblon Ligand
PT-179 is a selective cereblon ligand that facilitates targeted protein degradation without off-target effects commonly associated with Thalidomide derivatives. It binds specifically to cereblon, forming a ternary complex with proteins fused to zinc finger degrons, thereby promoting their degradation. This compound demonstrates efficient degradation of proteins tagged with SD40 or SD36, achieving DC50 values of 4.5 nM and 14.3 nM for eGFP, respectively. PT-179 is valuable for developing advanced protein degradation systems in cellular and molecular biology research. -
VHL Ligand
VH032 is a potent ligand for the von Hippel-Lindau (VHL) protein, acting primarily by inhibiting the interaction between VHL and hypoxia-inducible factor 1-alpha (HIF-1α). Its high affinity and specificity make VH032 an essential tool for research applications involving targeted protein degradation through PROTAC technology. This compound facilitates the study of VHL-mediated pathways and the regulation of hypoxic responses in various biological contexts. -
CRBN E3 Ligase Modulator
Golcadomide is a potent modulator of the CRBN E3 ligase, functioning as a CELMoD that promotes the ubiquitin-mediated proteasomal degradation of key transcription factors such as Ikaros and Aiolos through its interaction with the CRL4 CRBN substrate receptor. This compound has significant biological activity in cancer research, particularly in the study of chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL). Golcadomide's unique mechanism positions it as a valuable tool for exploring therapeutic pathways in hematological malignancies. -
Ligands for E3 Ligase
Lenalidomide-5-aminomethyl hydrochloride is a derivative of Lenalidomide that acts as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to target proteins, enabling targeted protein degradation through the formation of PROTACs (proteolysis-targeting chimeras). It is a valuable tool for researchers exploring protein homeostasis and therapeutic applications in cancer and other diseases where modulation of protein levels is critical. -
E3 Ligase Ligand
E3 Ligase Ligand 32 is a selective ligand for E3 ubiquitin ligase, facilitating the targeted degradation of specific proteins via the PROTAC approach. This compound can be conjugated with a protein ligand through a linker to create innovative PROTACs, such as the SMARCA2/4-degrader-29. E3 Ligase Ligand 32 is valuable for research into protein regulation and degradation pathways, enabling studies in cancer biology and therapeutic development. -
E3 Ligase Ligand
E3 Ligase Ligand 63 is an E3 ligase ligand that facilitates the synthesis of targeted protein degraders, including CDK2 degrader 2. This compound is instrumental in research applications focused on targeted protein degradation and ubiquitin-proteasome system modulation. Its use enables scientists to explore novel therapeutic strategies by selectively regulating protein levels in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-547 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the development of Proteolysis Targeting Chimeras (PROTACs). Its specific mechanism of action supports research in targeted protein degradation and the modulation of cellular pathways. -
Helios Degrader
ALV2 is a potent and selective Helios degrader that functions as a molecular glue. It exhibits an IC50 of 0.57 μM for binding to cereblon (CRBN). By targeting Helios, a zinc-finger transcription factor, ALV2 plays a crucial role in regulating the stability of Treg cell phenotype within the inflammatory tumor microenvironment, making it valuable for research in immunology and cancer therapy.
