E3 Ligase Ligands: Cereblon (CRBN) & VHL

Cat. No.: A32022

CAS No.: 1957235-57-2

Thalidomide-NH-(CH2)2-NH-Boc

Thalidomide-NH-(CH2)2-NH-Boc is a Boc-modified thalidomide derivative functioning as a ligand for the E3 ubiquitin ligase Cereblon (CRBN). This compound facilitates the recruitment of CRBN, making it an essential intermediate in the synthesis of PROTAC molecules. The Boc protecting group can be removed under acidic conditions, enabling further functionalization and development of targeted protein degradation strategies in chemical biology research.

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Cat. No.: A32089

CAS No.: 2140807-16-3

Thalidomide-4-NH-PEG2-COO(t-Bu)

Thalidomide-4-NH-PEG2-COO(t-Bu) is a thalidomide derivative that serves as a ligand for the E3 ubiquitin ligase Cereblon (CRBN). The t-Bu protecting group can be cleaved under acidic conditions, facilitating its incorporation into PROTAC (Proteolysis Targeting Chimera) synthesis. This compound is essential for research involving targeted protein degradation and the development of CRBN-based PROTAC molecules.

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Cat. No.: A32169

CAS No.: 2761385-94-6

Thalidomide-5-O-C5-NH2 hydrochloride

Thalidomide-5-O-C5-NH2 hydrochloride is a cereblon ligand that targets the E3 ligase CRBN. This compound facilitates the recruitment of CRBN protein, enabling the development of proteolysis-targeting chimeras (PROTACs) by connecting to other proteins through a linker. It serves as a valuable tool for studying protein degradation pathways and exploring therapeutic strategies in various biological contexts.

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Cat. No.: A32226

CAS No.: 2761406-70-4

Thalidomide-5-PEG2-NH2 hydrochloride

Thalidomide-5-PEG2-NH2 hydrochloride is a Thalidomide-derived ligand targeting cereblon (CRBN), an E3 ubiquitin ligase. This compound effectively facilitates the recruitment of CRBN for targeted protein degradation applications. It can be conjugated to other ligands via a linker, making it suitable for the development of PROTACs (proteolysis-targeting chimeras) to study protein function and regulation in various biological contexts.

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Cat. No.: A32264

CAS No.: 458151-34-3

Thalidomide-benzo

Thalidomide-benzo is a Thalidomide-derived ligand specifically designed for the recruitment of the E3 ligase protein cereblon (CRBN). This compound plays a crucial role in the formation of PROTACs (Proteolysis Targeting Chimeras) by enabling targeted degradation of specific proteins. Its application extends to research in cellular models to investigate protein degradation mechanisms and therapeutic strategies in oncology and other diseases.

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Cat. No.: A32307

CAS No.: 2863634-98-2

Thalidomide-5-NH-PEG1-NH2 hydrochloride

Thalidomide-5-NH-PEG1-NH2 hydrochloride is a Thalidomide-derived ligand that targets cereblon, a component of the E3 ubiquitin ligase complex. This compound facilitates the recruitment of CRBN proteins, enabling the development of PROTAC molecules by linking it to target proteins. Thalidomide-5-NH-PEG1-NH2 hydrochloride is valuable for researchers studying targeted protein degradation and E3 ligase modulation in therapeutic applications.

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$50.00

10 mg

$75.00

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Cat. No.: A32447

CAS No.: 1950635-36-5

Thalidomide-4-O-CH2-COO(t-Bu)

Thalidomide-4-O-CH2-COO(t-Bu) is a modified form of Thalidomide that serves as a ligand for the E3 ligase Cereblon (CRBN). It effectively recruits CRBN proteins, facilitating profound biological activity associated with protein degradation pathways. The tert-butyl protecting group can be removed under acidic conditions, enabling its use in the synthesis of PROTAC molecules. This compound is essential for researchers working on CRBN-based PROTAC development.

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Cat. No.: A32451

CAS No.: 2460022-53-9

Thalidomide-NH-C10-NH2 hydrochloride

Thalidomide-NH-C10-NH2 hydrochloride serves as a ligand for the E3 ligase cereblon (CRBN), facilitating targeted protein degradation. This compound enables the recruitment of CRBN to specific proteins through a linker, making it a valuable component in the design of PROTACs. Its application in research includes investigating protein homeostasis and therapeutic strategies for various diseases, including cancer and autoimmune disorders.

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Cat. No.: A32481

CAS No.: 1957235-67-4

Thalidomide-NH-(CH2)2-NH2 TFA

Thalidomide-NH-(CH2)2-NH2 TFA is an alkyl-modified Thalidomide derivative that functions as a ligand for the E3 ubiquitin ligase Cereblon (CRBN). By recruiting CRBN proteins, this compound is a critical intermediate in the development of CRBN-based PROTAC molecules. These PROTACs are engineered to selectively target and degrade the SHP2 protein, making them valuable tools for cancer research and therapeutic applications.

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Cat. No.: A32529

CAS No.: 2357110-84-8

Thalidomide-4-C3-NH2 hydrochloride

Thalidomide-4-C3-NH2 hydrochloride is a Thalidomide-derived ligand that targets cereblon, an E3 ubiquitin ligase. This compound is instrumental in the recruitment of CRBN protein, facilitating the development of PROTACs through linkers connecting the ligand to specific proteins. Thalidomide-4-C3-NH2 hydrochloride is valuable in studies related to targeted protein degradation and therapeutic development in cancer and autoimmune disorders.

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Cat. No.: A32534

CAS No.: 2694727-94-9

Thalidomide-5-O-C3-NH2 hydrochloride

Thalidomide-5-O-C3-NH2 hydrochloride is a novel ligand specifically targeting cereblon (CRBN), functioning as a key component in the recruitment of CRBN protein within protein degradation pathways. This compound is particularly valuable in the development of PROTACs (Proteolysis Targeting Chimeras), enabling the selective degradation of target proteins through the ubiquitin-proteasome system. It holds significant potential for applications in cancer research and therapeutic development by modulating protein activity and turnover.

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Cat. No.: A32543

CAS No.: 2412056-28-9

Thalidomide-5-NH-CH2-COO(t-Bu)

Thalidomide-5-NH-CH2-COO(t-Bu) serves as a ligand for the E3 ubiquitin ligase Cereblon (CRBN). This derivative of Thalidomide features a t-Bu protecting group, which can be removed under acidic conditions, facilitating the development of proteolysis-targeting chimeras (PROTACs). Thalidomide-5-NH-CH2-COO(t-Bu) is crucial for synthesizing CRBN-based PROTACs, enabling targeted protein degradation for various biological research applications.

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Cat. No.: A32768

CAS No.: 2682112-10-1

Thalidomide-5-O-CH2-COO(t-Bu)

Thalidomide-5-O-CH2-COO(t-Bu) is a thalidomide derivative that functions as a ligand for cereblon (CRBN), facilitating the recruitment of the CRBN protein. The tert-butyl protecting group can be cleaved under acidic conditions, enabling its use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as a critical intermediate in the development of CRBN-based PROTAC molecules for targeted protein degradation research.

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Cat. No.: A32792

CAS No.: 2863635-01-0

Thalidomide-5-NH-PEG3-NH2 hydrochloride

Thalidomide-5-NH-PEG3-NH2 hydrochloride is an E3 ligase ligand derived from Thalidomide that selectively engages cereblon (CRBN) proteins. This compound facilitates the synthesis of PROTAC (proteolysis-targeting chimeras) by serving as a connector for target proteins, thereby enabling targeted degradation through the ubiquitin-proteasome pathway. Its applications extend to various areas of biochemical research, particularly in studying protein homeostasis and therapeutic degradation strategies.

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Cat. No.: A32818

CAS No.: 2648939-40-4

Thalidomide-5,6-Cl

Thalidomide-5,6-Cl is a thalidomide-derived compound that functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN, making it a valuable tool for the development of PROTACs (Proteolysis Targeting Chimeras). Thalidomide-5,6-Cl is utilized in research applications focused on targeted protein degradation and the modulation of cellular pathways influenced by CRBN activity.

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Cat. No.: A32839

CAS No.: 2357107-60-7

Thalidomide-5-propoxyethanamine

Thalidomide-5-propoxyethanamine is an E3 ligase ligand specifically designed to target cereblon (CRBN). This compound enhances the recruitment of the CRBN protein, playing a crucial role in modulating protein homeostasis and ubiquitin-proteasome pathways. It is useful for research applications involving targeted protein degradation and the study of CRBN-related signaling pathways.

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Cat. No.: A32898

CAS No.: 2230956-57-5

Thalidomide-5-PEG2-Cl

Thalidomide-5-PEG2-Cl is a Thalidomide-derived ligand specifically targeting cereblon (CRBN), facilitating the recruitment of this E3 ligase. It is instrumental in the design and synthesis of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation studies. This reagent is valuable in elucidating CRBN-mediated pathways and exploring therapeutic avenues in cancer and other diseases.

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$40.00

10 mg

$65.00

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Cat. No.: A32918

CAS No.: 2761398-05-2

Thalidomide-5-O-C6-NH2 hydrochloride

Thalidomide-5-O-C6-NH2 hydrochloride is a Thalidomide-derived ligand targeting the E3 ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN, enabling the development of proteolysis-targeting chimeras (PROTACs) by linking it to other proteins. Key applications include targeted degradation studies and biological research involving ubiquitin-proteasome pathways.

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Cat. No.: A32947

CAS No.: 2758432-02-7

Thalidomide 4'-ether-PEG1-azide

Thalidomide 4'-ether-PEG1-azide is a Thalidomide-derived ligand that specifically targets cereblon (CRBN), facilitating its recruitment for protein degradation. This compound is utilized in the development of proteolysis-targeting chimeras (PROTACs) to enhance targeted protein removal in cellular systems. Its unique structure promotes effective binding and functional interactions in E3 ligase-mediated pathways, supporting studies in protein regulation and therapeutic discovery.

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Cat. No.: A32997

CAS No.: 2377032-39-6

Thalidomide-NH-CH2-COOH TFA

Thalidomide-NH-CH2-COOH TFA is a thalidomide-derived ligand targeting the E3 ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN, making it a valuable tool in the design of PROTACs for targeted protein degradation research. Its application in the development of bifunctional molecules allows for enhanced modulation of protein levels and contributes significantly to the study of protein homeostasis and therapeutic strategies.

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1 mg

$25.00

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$60.00

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Thalidomide 4'-oxyacetamide-C1-PEG3-C3-amine hydrochloride

Cat. No.: A33139

CAS No.: 2564466-93-7

Thalidomide 4'-oxyacetamide-C1-PEG3-C3-amine hydrochloride

Thalidomide 4'-oxyacetamide-C1-PEG3-C3-amine hydrochloride acts as a functionalized cereblon ligand, primarily utilized in PROTAC (proteolysis-targeting chimeras) research and development. It features a terminal amine, enabling easy conjugation to target protein ligands, thereby facilitating targeted degradation of specific proteins in cellular assays. This compound supports investigations into targeted protein degradation mechanisms and contributes to the advancement of therapeutic strategies in various disease models.

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Cat. No.: A35648

CAS No.: 1467165-30-5

XB2M54

XB2M54 is a selective antagonist of X-linked inhibitor of apoptosis protein (XIAP), functioning as a ligand for E3 ligases. It effectively inhibits NOD2-mediated inflammatory signaling pathways, making it a valuable tool in inflammation research. Additionally, XB2M54 can be employed in the synthesis of PROTAC ERα Degrader-1, facilitating studies on targeted protein degradation and its implications in therapeutic applications.

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Cat. No.: A40394

CAS No.: 2376139-66-9

(S,R,S)-AHPC-Me-amide-C9-acid

(S,R,S)-AHPC-Me-amide-C9-acid is an E3 ligase ligand-linker conjugate designed for targeted protein degradation applications. This reagent facilitates the synthesis of PROTAC SMARCA2 degrader-31, enabling investigations into the modulation of protein levels via the ubiquitin-proteasome system. Its unique structure enhances selectivity and efficacy in the degradation of specific target proteins, making it a valuable tool in chemical biology and therapeutic research.

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Cat. No.: A42505

CAS No.: 3031995-12-4

E3 ligase Ligand 36

E3 Ligase Ligand 36 is a potent E3 ligase ligand that serves as a key substrate for the synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates targeted protein degradation and has been utilized in the development of PROTAC BRM/BRG1 degrader-1. This compound provides valuable tools for research in protein regulation and therapeutic applications in various diseases.

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Cat. No.: A43950

CAS No.: 382608-09-5

(Rac)-Spirotetramat-enol

(Rac)-Spirotetramat-enol serves as a ligand for E3 ligases, demonstrating significant potential in targeted protein degradation research. Primarily involved in the modulation of acetyl-CoA carboxylase, this compound facilitates the synthesis of PROTAC ADC degraders. Its application in the development of innovative therapeutic strategies underscores its importance in chemical biology and drug discovery.

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