Fig. 1 · Structure
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5-Aminothalidomide
Ligands for E3 Ligase
5-Aminothalidomide is an E3 ligase ligand that plays a crucial role in PROTAC technology. This compound facilitates the synthesis of targeted protein degraders, enabling the development of specific PROTACs such as BRD9 Degrader-7. Its ability to modulate protein levels provides valuable insights into proteostasis and therapeutic intervention in various biological studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 191732-76-0 |
| Applications | Ligands for E3 Ligase |
| Formula | C13H11N3O4 |
| Molecular Weight | 273.25 |
| SMILES | C1(N(C(C=2C=C(C=CC12)N)=O)C3C(NC(CC3)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.