Fig. 1 · Structure
Documents & Downloads
VH 101, acid
Protein Ligand
VH 101, acid is a functionalized von-Hippel-Lindau (VHL) protein ligand designed for PROTAC (proteolysis-targeting chimera) research and development. This compound features an E3 ligase ligand along with an alkyl linker equipped with a terminal amine, facilitating conjugation to a target protein ligand. VH 101, acid offers key applications in targeted protein degradation studies, providing insights into therapeutic interventions in various diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2408341-97-7 |
| Applications | Protein Ligand |
| Formula | C28H35FN4O6S |
| Molecular Weight | 574.66 |
| SMILES | O=C(C1(CC1)F)N[C@@H](C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(N[C@H](C3=CC=C(C4=C(N=CS4)C)C=C3)CC(O)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.