Fig. 1 · Structure
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Lenalidomide-Br
Ligands for E3 Ligase
Lenalidomide-Br is an analog of the cereblon (CRBN) ligand Lenalidomide, functioning as a ligand for the E3 ubiquitin ligase. This compound effectively recruits the CRBN protein, facilitating targeted protein degradation. Lenalidomide-Br can be utilized to create PROTACs, such as the PROTAC STAT3 degrader SD-36, expanding its application in studies focused on targeted therapy and protein modulation in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2093387-36-9 |
| Applications | Ligands for E3 Ligase |
| Formula | C13H11BrN2O3 |
| Molecular Weight | 323.14 |
| SMILES | O=C(C(N(CC1=C2C=CC=C1Br)C2=O)CC3)NC3=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.