Catalog No.
Product Name
Application
Product Information
Citations
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Ligands for E3 Ligase
3-(4-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a ligand for the E3 ligase cereblon (CRBN). This compound enables the targeted recruitment of CRBN, facilitating the degradation of specific proteins through the formation of proteolysis-targeting chimeras (PROTACs). It is a valuable tool for studying protein homeostasis and exploring therapeutic strategies in various diseases, including cancer. -
Ligand for E3 Ligase
CRBN ligand-397 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be connected to a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. Its utility in research includes the development of innovative therapeutic strategies that exploit the ubiquitin-proteasome system. -
Ligand for E3 Ligase
(S,R,S)-AHPC-Me-NHBoc is a selective ligand for the E3 ubiquitin ligase von Hippel-Lindau (VHL), facilitating the recruitment of the VHL protein to target substrates. This compound can be conjugated with target protein ligands through a linker to create an effective PROTAC (Proteolysis Targeting Chimera). Its unique properties make it a valuable tool in the study of targeted protein degradation and related biological pathways. -
Ligand for E3 Ligase
5-Br-6-F-Desamino lenalidomide is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand using a linker, enabling the formation of a PROTAC (proteolysis-targeting chimeras). Its application in targeted protein degradation research offers significant potential for therapeutic intervention in various diseases. -
DCAF15 Ligand
DCAF15 ligand-1 is a selective ligand for the E3 ubiquitin ligase DCAF15, facilitating its role in substrate recognition and ubiquitination processes. This compound is pivotal in biochemical studies aimed at understanding the mechanistic pathways involving DCAF15-mediated protein degradation. Additionally, DCAF15 ligand-1 can be utilized in the synthesis of associated compounds, such as IBG1, enhancing its relevance in research applications focused on targeted protein modulation. -
Ligands for E3 Ligase
KB02-COOH is a chemical compound that serves as a ligand for E3 ligase, playing a crucial role in the ubiquitin-proteasome system. This fragment is essential for the synthesis of proteolysis-targeting chimeras (PROTACs), including variants such as KB02-JQ1 and KB02-SLF. Researchers can utilize KB02-COOH in studies focused on targeted protein degradation and the modulation of protein activity within cellular pathways. -
Ligand for E3 Ligase
Desamino lenalidomide-6-COOH is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker, enabling the development of a PROTAC (Proteolysis Targeting Chimeras). Desamino lenalidomide-6-COOH is essential for research in targeted protein degradation and has potential applications in drug discovery and therapeutic interventions. -
Ligand for E3 Ligase
Desamino lenalidomide-CH2NH2 hydrochloride functions as a ligand for the E3 ubiquitin ligase protein cereblon (CRBN). This compound is instrumental in the targeted recruitment of cereblon, facilitating the development of protein-targeted degradation strategies. It can be conjugated with a target protein ligand through a suitable linker to create a proteolysis-targeting chimera (PROTAC), thereby advancing research in protein degradation and targeted therapies. -
Ligand for E3 Ligase
CRBN ligand-734 is a potent ligand for the E3 ubiquitin ligase, cereblon (CRBN). This compound facilitates the recruitment of CRBN, enabling targeted protein degradation through the formation of PROTAC (proteolysis-targeting chimeras) by linking it with a target protein ligand via a suitable linker. Its utility is significant in studies focusing on targeted therapy and protein regulation mechanisms in various biological contexts. -
E3 Ligase Ligand
E3 ligase Ligand PG is a selective ligand targeting the CRBN E3 ubiquitin ligase, exhibiting strong binding affinity with an IC50 of 2.191 μM. This compound is suitable for applications involving the recruitment of the CRBN protein, facilitating the development of proteolysis-targeting chimeras (PROTACs). E3 ligase Ligand PG can be utilized in conjunction with BMS-202 to form PROTAC PD-L1 degrader-1, enabling targeted degradation of specific proteins for therapeutic research purposes. -
Ligands for E3 Ligase
(S,R,S)-AHPC-Me dihydrochloride targets the von Hippel-Lindau (VHL) protein as a ligand for E3 ligase recruitment. This compound serves as a critical precursor for the synthesis of ARV-771, a PROTAC degrader that utilizes the VHL E3 ligase to facilitate the degradation of BET proteins. It has demonstrated potent activity in degrading BET proteins in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM, highlighting its potential for therapeutic applications in cancer research. -
Ligand for E3 Ligase
Desamino lenalidomide-5-F is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), essential for directing protein degradation via the ubiquitin-proteasome system. This compound facilitates the recruitment of cereblon and can be utilized to create PROTACs by conjugating it to target protein ligands through a linker. Desamino lenalidomide-5-F is instrumental in studies focusing on targeted protein degradation and the exploration of novel therapeutic strategies in various diseases. -
Lenalidomide Analog
3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione functions as a Lenalidomide analog with potential utility in targeted protein degradation research. This compound exhibits properties that may facilitate the design of proteolysis-targeting chimeras (PROTACs), thereby enabling the selective degradation of proteins of interest. Further investigation into its biological activity could contribute to advancements in therapeutic strategies aimed at modulating cellular proteostasis and addressing various diseases. -
Ligand for E3 Ligase
CRBN ligand-798 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It can be conjugated to a target protein ligand via a linker to create a proteolysis-targeting chimera (PROTAC). This compound is valuable for research applications focused on targeted protein degradation and the modulation of cellular pathways involving CRBN. -
Ligand for E3 Ligase
Pomalidomide-5-OH (5-hydroxy pomalidomide) serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN protein. This compound can be utilized in the synthesis of PROTACs by linking it to other ligands, enabling targeted protein degradation. Its applications in chemical biology and drug discovery make it an essential tool for researchers investigating proteostasis and therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-394 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound is instrumental in the development of PROTACs by enabling the conjugation of target protein ligands through a linker. Its utility extends to studies in targeted protein degradation and therapeutic applications. -
VHL Ligand
VHL Ligand 14 is a specific ligand for the von Hippel-Lindau (VHL) protein, playing a crucial role in the development of PROTACs that target estrogen receptor α (ERα) for degradation. With a binding affinity of 196 nM, it facilitates the targeted ubiquitination and subsequent proteasomal degradation of ERα. This compound is primarily utilized in research applications focused on cancer biology and targeted protein degradation strategies. -
Ligand for E3 Ligase
Lenalidomide 5'-piperazine hydrochloride is a ligand for the E3 ubiquitin ligase Cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling the development of proteolysis-targeting chimera (PROTAC) molecules for targeted protein degradation. This compound is particularly useful in research focused on modulating protein levels in cellular pathways, contributing to the study of various diseases and therapeutic interventions. -
Isomer
(S,S,S)-AHPC-Boc is a stereoisomer of (S,R,S)-AHPC-Boc and serves as a valuable experimental control in research. This compound specifically relates to the recruitment of the von Hippel-Lindau (VHL) protein, which plays a critical role in targeted protein degradation through PROTAC technology. By providing a reliable reference point, (S,S,S)-AHPC-Boc facilitates investigations into the efficacy and selectivity of VHL ligands in cellular systems. -
Ligands for E3 Ligase
Lenalidomide-6-F is a modified derivative of Lenalidomide that functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound effectively recruits CRBN, facilitating the targeted degradation of specific proteins via the PROTAC (proteolysis-targeting chimera) mechanism. Lenalidomide-6-F is valuable for research applications focused on the modulation of cellular protein levels and the development of novel therapeutic strategies in cancer and other diseases. -
CRBN Ligand
2-Methoxyphenyl dihydrouracil serves as a ligand for the cereblon (CRBN) protein, enhancing its interaction in targeted protein degradation assays. This compound is valuable for the development of PROTACs (Proteolysis Targeting Chimeras), facilitating studies in targeted therapy and protein regulation. Its applications extend to research focused on modulating protein levels and understanding ubiquitin-proteasome system mechanisms. -
Ligand for E3 Ligase
Hydrouracil-3-Ph-COOH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in biochemical applications. This compound is designed to be employed in the development of proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands through a suitable linker, making it valuable in targeted protein degradation research. Its utility in creating complex biologics underscores its significance in advancing studies of protein modulation and therapeutic strategies. -
Ligand for E3 Ligase
CC-17369 (7-Hydroxy pomalidomide) serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound, a metabolite of Pomalidomide, selectively recruits CRBN, making it a valuable tool in targeted protein degradation studies. CC-17369 can be conjugated to other ligands via a linker to create PROTACs, facilitating research into novel therapeutic strategies for diseases involving protein dysregulation. -
Mdm2 E3 Ligase Inhibitor
MEL24 is an inhibitor of the Mdm2 E3 ligase, which plays a critical role in regulating p53 protein levels. This compound significantly reduces cell survival and enhances sensitivity to DNA-damaging agents in a p53-dependent manner. MEL24 is primarily utilized in antitumor research, contributing to studies aimed at understanding and overcoming resistance in cancer therapies. -
Ligands for E3 Ligase
Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride is an E3 ligase ligand designed for PROTAC (proteolysis-targeting chimera) development. This compound serves as a protein degrader, featuring a terminal piperidine that facilitates further chemical modifications. Its unique structure allows for enhanced interaction with target proteins, making it a valuable tool for studying targeted protein degradation in various research applications. -
Ligand for E3 Ligase
CRBN ligand-660 is a ligand targeting the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to construct a proteolysis-targeting chimera (PROTAC), making it useful in studies involving targeted protein degradation and cellular protein modulation. Its application in research enables the exploration of new therapeutic strategies by harnessing the ubiquitin-proteasome system. -
Thalidomide Analog
Thalidomide acid is a Thalidomide analog that primarily functions as a target for Proteolysis Targeting Chimeras (PROTACs). It exhibits significant activity in modulating protein degradation and is utilized in chemical biology studies aimed at elucidating proteostasis and targeted therapeutics. This compound serves as a valuable tool in drug discovery and development, particularly for diseases related to dysregulated protein levels. -
Thalidomide Analog
2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione is a Thalidomide analog primarily engaged in protein degradation pathways through PROTAC technology. Exhibiting modulatory effects on the immune system and anti-angiogenic properties, this compound is instrumental in investigational studies targeting multiple myeloma and other malignancies. Its distinctive structural attributes facilitate the exploration of targeted therapies and the development of innovative drug delivery platforms. -
Ligands for E3 Ligase
3-(4-Bromo-2-chlorophenyl)piperidine-2,6-dione is a ligand for the CRBN-type E3 ubiquitin ligase, facilitating targeted protein degradation via the PROTAC (proteolysis-targeting chimeras) approach. This compound can be employed in the development of novel therapeutics that harness the ubiquitin-proteasome system for selective removal of specific proteins. Its applications are significant in disease models where modulation of protein levels is desired for research and therapeutic purposes. -
Ligand for E3 Ligase
CRBN ligand-224 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC), allowing for targeted degradation of proteins in cellular systems. Its application is significant in drug discovery and development, particularly for modulating the activity of specific proteins involved in various diseases. -
Ligand for E3 Ligase
Desamino lenalidomide-pinacolborane is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand using a linker to create a PROTAC, enabling targeted protein degradation. Its applications extend to the study of ubiquitin-mediated pathways and drug development strategies aimed at modulating protein levels in various biological contexts. -
Ligand for E3 Ligase
Desamino lenalidomide-NO2 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in targeted protein degradation pathways. This compound can be conjugated to target protein ligands through a linker to design and develop PROTAC (proteolysis-targeting chimeras) molecules, enabling precise modulation of protein levels in research applications. Its utility in studying protein degradation mechanisms makes it a valuable tool for drug discovery and cancer research. -
E3 Ubiquitin Ligase Ligand
CRBN ligand-11 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating targeted protein degradation. This compound is instrumental in the synthesis of PROTACs (Proteolysis Targeting Chimeras), which are employed in cellular research to modulate protein levels and investigate the role of specific proteins in various biological processes. Its utility in drug discovery and development marks it as a significant tool for researchers exploring innovative therapeutic approaches. -
VHL Ligand
GNE7599 is a high-affinity von Hippel-Lindau (VHL) ligand, characterized by a dissociation constant (Kd) of 540 pM. This compound serves as a crucial component for the development of Proteolysis Targeting Chimeras (PROTACs), facilitating the targeted degradation of specific proteins. Its ability to bind with high specificity to VHL makes it an invaluable tool for research in targeted protein modulation and therapeutic applications in cancer and other diseases. -
Ligand for E3 Ligase
(R,S,S)-VH032 is a ligand for E3 ligase, specifically targeting the von Hippel-Lindau (VHL) protein. This compound inhibits the VHL/HIF-1α interaction and is pivotal in the synthesis of PROTACs. Notably, (R,S,S)-VH032 facilitates the development of tau-targeting small molecule PROTAC C004019, making it a valuable tool in research focused on targeted protein degradation and therapeutic applications. -
E3 ubiquitin ligase ligand
MS1262 is a selective ligand for the E3 ubiquitin ligase SPOP, targeting the SPOP substrate GLP. This compound facilitates the recruitment of SPOP and is utilized in research to study ubiquitination processes and related signaling pathways. MS1262 serves as a precursor for the synthesis of MS479, further expanding its utility in chemical biology investigations. -
E3 Ligase Ligand
Lenalidomide-F is an E3 ligase ligand that targets cereblon, facilitating the development of PROTAC molecules. It is specifically designed for use with LWY713, a potent degrader of FLT3, exhibiting a DC50 value of 0.64 nM. This compound selectively induces the degradation of FLT3 through proteasome-dependent mechanisms. Lenalidomide-F is valuable for research applications focused on targeted protein degradation and the therapeutic potential of PROTACs in oncology. -
Ligand for E3 Ligase
Glutarimide-(1-oxoisoindoline-5-carbaldehyde) functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the cereblon protein, enabling targeted protein degradation approaches. It can be conjugated with specific target protein ligands through a linker, making it suitable for the development of PROTACs in proteomics research and drug discovery applications. -
Ligand for E3 Ligase
Desamino lenalidomide-7-OH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon to target proteins. This compound can be utilized in the design of PROTACs by linking it to a target protein ligand via a suitable linker. Its biological activity enables selective modulation of protein levels, making it a valuable tool in targeted protein degradation research applications. -
Thalidomide Analog
2-(2,6-Dioxopiperidin-3-yl)-4-iodoisoindoline-1,3-dione is a Thalidomide analog that features an iodine substitution on the isoindoline structure. This compound exhibits significant biological activity related to anti-inflammatory and anti-angiogenic properties. It is primarily utilized in research applications investigating the mechanisms of action of Thalidomide and its derivatives in various therapeutic contexts, particularly in cancer and autoimmune disorders. -
Lenalidomide Derivative
Lenalidomide-4-Br-7-fluoro is a derivative of Lenalidomide featuring bromine and fluorine substituents on the benzyl ring. This compound exhibits immunomodulatory properties, enhancing immune responses and exhibiting anti-tumor activity. It can be utilized in research to investigate the mechanisms of action of Lenalidomide and its analogs, as well as their potential therapeutic applications in hematological malignancies. -
Ligands for E3 Ligase
1-(4-Pip-Ph)-DHP-dione is a ligand specifically designed for targeting E3 ligases. It plays a crucial role in the development of proteolysis-targeting chimeras (PROTACs), particularly in the synthesis of the HPK1 Degrader-2. This compound is valuable for research in targeted protein degradation and provides insights into E3 ligase-mediated cellular processes. -
Ligand for E3 Ligase
Desamino lenalidomide-5-COOH is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of cereblon to target proteins, enabling the formation of PROTACs (proteolysis-targeting chimeras) through a strategic linker attachment. Desamino lenalidomide-5-COOH is instrumental in studying targeted protein degradation pathways and has applications in drug discovery and therapeutic development. -
CRBN Ligand
N-Methylated pomalidomide acts as a selective ligand for cereblon (CRBN). This derivative of pomalidomide lacks the ability to recruit CRBN, making it a valuable negative control in studies involving pomalidomide. Additionally, N-methylated pomalidomide can be utilized in the synthesis of PROTACs, thereby assisting researchers in the exploration of targeted protein degradation pathways and mechanisms. -
Ligand for E3 Ligase
Desamino lenalidomide-6-OH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized in the synthesis of PROTACs by linking it to a target protein ligand through a suitable linker. Its applications include studies in targeted protein degradation and therapeutic strategies in cancer research. -
VHL Ligand
VH 101, thiol serves as a selective VHL ligand, primarily utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enables the targeted degradation of specific proteins by harnessing the ubiquitin-proteasome system, making it instrumental in drug discovery and therapeutic research. Its robust binding affinity and specificity towards VHL provide an effective tool for studies aimed at elucidating protein regulation mechanisms and developing novel treatments for various diseases. -
Ligand for E3 Ligase
CRBN ligand-395 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated with a target protein ligand using a linker to form a proteolysis-targeting chimera (PROTAC), enabling the targeted degradation of specific proteins. CRBN ligand-395 is valuable in research applications involving protein degradation and modulation of cellular pathways. -
Ligands for E3 Ligase
VH032-OH is a ligand for the E3 ligase Von Hippel-Lindau (VHL), enabling targeted protein degradation. This compound can be utilized in the development of PROTACs (Proteolysis Targeting Chimeras) by linking it to target proteins. VH032-OH facilitates the selective ubiquitination and subsequent proteasomal degradation of substrate proteins, making it a valuable tool for investigating protein turnover and cellular regulation in various research applications. -
Cereblon Ligand
E3 Ligase Ligand 56 is a specific ligand for the E3 ubiquitin ligase Cereblon, facilitating targeted protein degradation through proteolysis-targeting chimeras (PROTACs). This compound is instrumental in the synthesis of PROTAC CDK9 degrader-11, supporting research in targeted degradation mechanisms and their applications in cellular processes. Its utility in developing novel therapeutics makes it a valuable reagent for studies in oncology and pharmacology. -
Cereblon Binder
E3 Ligase Ligand 23 is a cereblon binder that facilitates the degradation of Ikaros and Aiolos through the ubiquitin-proteasome pathway. This compound is instrumental in probing the mechanisms of targeted protein degradation and the role of cereblon in modulating protein levels. It is valuable for research applications involving the regulation of immune responses and hematological malignancies.
