Catalog No.
Product Name
Application
Product Information
Citations
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E3 Ligase Activator
Thalidomide-iodo is an iodo-substituted E3 ligase activator. It plays a crucial role in the ubiquitin-proteasome pathway, facilitating targeted protein degradation. Thalidomide-iodo can serve as a valuable intermediate for further chemical modifications, allowing researchers to explore novel derivatives in the study of protein regulation and cellular processes. This compound is essential for investigations into therapeutic strategies related to various diseases, including cancer and immune disorders. -
Ligand for E3 Ligase
Desamino lenalidomide-6-propyne is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC. Its applications include targeted protein degradation and modulation of cell signaling pathways for research in various biological contexts. -
Thalidomide Analog
Thalidomide-1-Me-5-NH2 is an aminated analog of Thalidomide, primarily targeting E3 ligase activation. This compound serves as a useful intermediate for the development of PROTAC (Proteolysis Targeting Chimera) molecules through amine derivatization. Researchers can utilize this reagent in studies focused on targeted protein degradation and related therapeutic applications. -
Thalidomide Analog
Deoxy-thalidomide-5-iodine is a Thalidomide analog that serves as a valuable tool in PROTAC (Proteolysis Targeting Chimeras) research. This compound is designed to facilitate targeted protein degradation by recruiting E3 ligases, enabling the selective elimination of specific proteins within cellular systems. Its unique structural modifications may enhance potency and efficacy in various biological assays, making it essential for advancing studies in targeted oncology and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-891 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to conjugate a target protein ligand through a linker, enabling the development of PROTAC molecules for targeted protein degradation studies. Its application is particularly relevant in drug discovery and the investigation of cellular pathways involving protein homeostasis. -
E3 Ligase Activator
Thalidomide 4-chloro is an E3 ligase activator that exhibits unique properties due to its chlorinated structure. This compound plays a significant role in promoting protein degradation pathways, making it valuable for research focused on modulating cellular processes. Additionally, Thalidomide 4-chloro serves as a versatile starting material for further derivatization through chlorine substitution, allowing for the exploration of novel analogs in chemical research. -
Ligand for E3 Ligase
Desamino lenalidomide-6-Br-5-F is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in targeted protein degradation assays. This compound can be conjugated to a target protein ligand using a linker to create a proteolysis-targeting chimera (PROTAC). Its versatile functionality makes it an essential tool for researchers investigating protein regulation and degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-884 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. It serves as a crucial tool for studies in protein regulation, cancer therapeutics, and other areas involving targeted protein modulation. -
Ligand for E3 Ligase
CRBN ligand-704 is a ligand for the E3 ubiquitin ligase cereblon (CRBN). It effectively recruits the CRBN protein for targeted protein degradation applications, facilitating the development of Proteolysis Targeting Chimeras (PROTACs). Its utility in research enables the selective modulation of protein levels, making it a valuable tool for studies in protein homeostasis and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-733 is a small molecule ligand targeting the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN, allowing for the targeted degradation of specific proteins when conjugated with a target protein ligand through a linker to create a PROTAC. This compound is valuable in research applications aimed at understanding protein function and developing protein degradation strategies in therapeutic contexts. -
Ligand for E3 Ligase
Desamino lenalidomide-7-F is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of cereblon to target proteins, allowing for the targeted degradation of specific intracellular proteins through the formation of PROTACs (Proteolysis Targeting Chimeras). This compound is valuable for researching protein regulation and therapeutic applications in oncology and other diseases. -
Ligand for E3 Ligase
CRBN ligand-838 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to effectively recruit the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC, enabling targeted degradation of specific proteins. CRBN ligand-838 is valuable for research applications in protein homeostasis and the study of targeted protein degradation pathways. -
Thalidomide Analog
Thalidomide-4-carbaldehyde is a Thalidomide analogue featuring an aldehyde functional group. This compound is known to recruit E3 ligases, facilitating the ubiquitination and subsequent proteolysis of target proteins, making it a valuable tool in studying protein degradation pathways. Its highly reactive aldehyde group engages in reductive amination reactions with amine nucleophiles, offering diverse applications in chemical biology and medicinal chemistry research. -
Ligand for E3 Ligase
Desamino lenalidomide-4-C-COOH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in targeted protein degradation applications. This compound can be conjugated to a target protein ligand through a linker, enabling the creation of Proteolysis Targeting Chimeras (PROTACs). Its utilization in research provides insights into protein regulation mechanisms and therapeutic strategies in diseases influenced by protein homeostasis. -
Thalidomide Analog
Thalidomide-5-carbaldehyde is a Thalidomide analog featuring an aldehyde functional group. It actively interacts with E3 ligases, facilitating the ubiquitination and degradation of specific target proteins, thereby contributing to cellular regulation. The aldehyde group exhibits high reactivity towards amine nucleophiles, enabling reductive amination and other chemical modifications, making it a valuable tool for research in protein degradation pathways and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-883 is a ligand that targets the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific protein partners. This compound can be utilized in the synthesis of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. CRBN ligand-883 serves as a valuable tool for research applications aimed at studying targeted protein degradation and modulatory effects in cellular processes. -
Thalidomide Analog
Thalidomide-1-Me,4-OH is an analogue of Thalidomide, featuring an additional methyl group on the glutarimide moiety. This modification abolishes its interaction with the E3 ubiquitin ligase, cereblon (CRBN), which is critical for the ubiquitination and subsequent proteolytic degradation of target proteins. Thalidomide itself is well-known for its immunomodulatory and anti-inflammatory properties, making Thalidomide-1-Me,4-OH a valuable tool for investigating the molecular mechanisms of CRBN-mediated drug action and cellular protein regulation in research applications. -
Ligands for E3 Ligase
CRBN ligand-47 is a potent ligand for the CRBN-type E3 ubiquitin ligase, facilitating targeted protein degradation through the formation of PROTACs (Proteolysis Targeting Chimeras). This compound exhibits effective recruitment of E3 ligase activity, making it valuable for research in protein homeostasis and therapeutic interventions in various diseases. Its role in modulating ubiquitin-mediated pathways underscores its utility in chemical biology and drug discovery applications. -
Ligand for E3 Ligase
CRBN ligand-618 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be connected to a target protein ligand through a linker, enabling the development of PROTACs (proteolysis-targeting chimeras). CRBN ligand-618 is valuable for research applications focused on targeted protein degradation and modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-882 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a suitable linker to create a proteolysis-targeting chimera (PROTAC). Its application is particularly relevant in targeted protein degradation research and therapeutic development. -
Ligand for E3 Ligase
N-Methyl-desamino lenalidomide-NH2 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), playing a crucial role in targeted protein degradation. This compound facilitates the recruitment of cereblon to specific target proteins, enabling the development of PROTACs (proteolysis-targeting chimeras) for precision research applications. It serves as a valuable tool for studying proteasomal degradation pathways and expanding the scope of targeted therapies in drug discovery. -
Ligand for E3 Ligase
CRBN ligand-225 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). Its utility in targeted protein degradation makes it a valuable tool in chemical biology research and drug discovery applications. -
Ligand for E3 Ligase
CRBN ligand-761 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). It is useful in research applications focused on targeted protein degradation and the modulation of cellular processes via ubiquitin-mediated pathways. -
E3 Ligase Activator
Thalidomide-1-Me,5-F is a fluorinated E3 ligase activator that functions by promoting the ubiquitination of target proteins. This compound exhibits key biological activity in modulating protein degradation pathways, making it valuable for research in cellular signaling and therapeutic interventions. Additionally, Thalidomide-1-Me,5-F can serve as a substrate for further derivatization via nucleophilic aromatic substitution (SNAr) reactions. -
Ligand for E3 Ligase
Hydrouracil-4-fluorobenzoate is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to conjugate with target protein ligands through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). Its application is significant in the study of protein degradation pathways and therapeutic development targeting specific proteins for degradation. -
Ligand for E3 Ligase
CRBN ligand-430 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed for use in PROTAC (proteolysis targeting chimera) technology, allowing for targeted degradation of specific proteins when linked to a target protein ligand through a suitable linker. Its application is pivotal in the study of protein homeostasis and therapeutic development in diseases where protein dysregulation is a factor. -
Ligand for E3 Ligase
Desamino lenalidomide-5-C-COOH is a ligand for the E3 ubiquitin ligase cereblon (CRBN). It effectively recruits the cereblon protein, enabling the formation of targeted protein degraders. This compound can be connected to a target protein ligand through a linker, facilitating the development of proteolysis-targeting chimeras (PROTACs) for applications in drug discovery and biochemistry research. -
Immunomodulatory/Antineoplastic Agent
Lenalidomide hydrochloride is an oral immunomodulatory agent targeting cereblon (CRBN), acting as a molecular glue. It promotes the selective ubiquitination and degradation of transcription factors IKZF1 and IKZF3 via the CRBN-CRL4 ubiquitin ligase complex. This mechanism effectively inhibits the growth of mature B-cell lymphomas, including multiple myeloma, while also inducing the release of IL-2 from T cells, making it valuable in cancer research and therapeutic applications. -
E3 Ligase Ligand
VHL Ligand 39 is a conjugate of the VHL E3 ligase, acting as a pivotal intermediate in the construction of PROTAC (proteolysis-targeting chimera) molecules. This compound facilitates targeted protein degradation by harnessing the ubiquitin-proteasome system, enabling researchers to modulate protein levels for various biological studies. Its applications extend to investigating cellular signaling pathways and therapeutic mechanisms involving targeted degradation of specific proteins. -
E3 Ligase Ligand
2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe is an E3 ligase ligand specifically targeting CRBN. This compound features an additional methyl group on the glutarimide moiety of thalidomide, which disrupts its binding affinity to the E3 ligase. It serves as a negative control for the NAMPT degrader SIAIS630121, making it a valuable tool for research involving targeted protein degradation and molecular pathways regulated by E3 ligases. -
Ligands for E3 Ligase
Lenalidomide-5-aminomethyl is a cereblon (CRBN) ligand that facilitates the recruitment of the CRBN protein, enabling targeted cellular degradation. This compound can be utilized as a key component in the development of PROTACs (proteolysis-targeting chimeras), which harness the ubiquitin-proteasome system for the selective degradation of specific proteins. Its significant role in E3 ligase-mediated pathways makes it valuable for research in targeted protein modulation and therapeutic development. -
Target protein ligand
Aster-A Ligand-3 is a target protein ligand that acts as a critical component for the synthesis of PROTAC Aster-A degrader. This compound facilitates targeted protein degradation, making it valuable in the study of protein homeostasis and cellular signaling pathways. Its application is relevant in drug discovery and therapeutic development, particularly for diseases related to protein dysregulation. -
E3 Ligase Ligand
E3 Ligase Ligand 26 is a selective ligand for E3 ubiquitin ligases, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of the PROTAC SOS1 degrader, contributing to targeted protein degradation research. Its application extends to studies of cellular pathways and potential therapeutic interventions for various diseases through the modulation of protein levels. -
E3 Ligase Ligand
E3 Ligase Ligand 46 is a potent ligand that targets E3 ligases, facilitating the development of targeted protein degradation strategies. It is specifically utilized in the synthesis of PROTAC SMARCA2/4 degrader-36, enabling the selective degradation of cellular proteins. This compound offers valuable insights into the role of E3 ligases in cellular signaling and protein homeostasis, making it essential for research in targeted therapeutics and protein regulation. -
Ligands for E3 Ligase
E3 ligase Ligand 42 is an E3 ubiquitin ligase ligand designed for targeted protein degradation applications. It can be conjugated to a target protein ligand via a linker, facilitating the synthesis of PROTAC AR Degrader-6. This compound effectively induces ubiquitination and subsequent degradation of proteins associated with cancer progression, making it a valuable tool for research in cancer biology and therapeutic development. -
E3 Ligase Ligand
E3 Ligase Ligand 68 is an E3 ligase ligand utilized in the development of PROTAC (proteolysis-targeting chimeras) molecules. It facilitates targeted protein degradation by enabling the conjugation of an E3 ligase to a ligand that binds the protein of interest. This reagent is essential for research applications aimed at studying protein homeostasis, disease mechanisms, and therapeutic interventions involving targeted protein degradation. -
MAGE-A11 Inhibitor
SJ1008066 is an inhibitor of the MAGE-A11 protein, demonstrating an IC50 of 0.13 μM. It specifically binds to the MAGE homology domain (MHD), effectively disrupting the interaction between MAGE-A11 and PCF11. This mechanism presents valuable opportunities for research into cancer biology and therapeutic strategies targeting MAGE-A11 associated pathways. -
Cereblon Binder
E3 Ligase Ligand 22 is a cereblon binder that facilitates the targeted degradation of Ikaros and Aiolos proteins through the ubiquitin-proteasome pathway. This compound is valuable for studies investigating protein homeostasis, immune regulation, and the mechanism of action of immunomodulatory drugs. Its selective interaction with cereblon makes it a useful tool for researchers exploring targeted protein degradation strategies in various biological contexts. -
Ligands for E3 Ligase
(R,S,S)-VH032-Me is a ligand for E3 ubiquitin ligase, playing a crucial role in targeted protein degradation through the ubiquitin-proteasome pathway. It can be conjugated to proteins via a linker to create PROTACs such as dTAGV-1-NEG, which facilitate the selective degradation of oncogenic proteins. This compound is essential for studies involving targeted protein degradation, offering valuable insights into cancer biology and therapeutic development.
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Ligand for E3 Ligase
Pomalidomide-5-O-CH3 is a synthetic derivative of Pomalidomide designed as a ligand for cereblon (CRBN), an E3 ubiquitin ligase. This compound facilitates the recruitment of CRBN, enabling targeted protein degradation through PROTAC (proteolysis targeting chimeras) technology. Pomalidomide-5-O-CH3 is valuable for research in targeted therapy and ubiquitin-proteasome system studies, contributing to insights in cancer treatment and cellular regulation. -
Ligands for E3 Ligase
KLHDC2-IN-1 is a ligand that specifically targets the ubiquitin E3 ligase KLHDC2, exhibiting a dissociation constant (Kd) of 160 nM. This compound facilitates the development of PROTACs, which are designed to induce degradation of BRD4 in cellular environments. Its application in cellular research underscores its potential utility in studying protein degradation mechanisms and therapeutic strategies targeting BRD4-related pathways. -
Ligands for E3 Ligase
E3 ligase Ligand 58 is a selective ligand for E3 ligases, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in targeted protein degradation, enabling researchers to explore cellular mechanisms and therapeutic applications. E3 ligase Ligand 58 serves as a valuable tool in drug development and biological research focused on post-translational modifications. -
Atox1/CCS PROTAC Degrader
DA-PROTAC is a selective PROTAC degrader targeting the copper ion-transport proteins Atox1 and CCS. By facilitating the recruitment of E3 ligase, DA-PROTAC promotes the ubiquitination and subsequent proteasomal degradation of both Atox1 and CCS. This compound is particularly valuable for research in triple negative breast cancer, allowing for the investigation of copper transport mechanisms and their implications in tumor biology. -
DCAF1 Ligand
CYCA-117-70 is a ligand for DCAF1, exhibiting a binding affinity (KD) of 70 μM. It serves as an effective chemical handle for the development of proteolysis-targeting chimeras (PROTACs) that recruit DCAF1. This compound is valuable in research aiming to modulate protein degradation pathways, providing insights into cellular regulation and potential therapeutic applications. -
Ligands for E3 Ligase
CRBN ligand-17 is an E3 ubiquitin ligase ligand that targets the cereblon (CRBN) substrate recognition domain. This compound is essential for the design and synthesis of PROTACs (proteolysis-targeting chimeras), which facilitate targeted protein degradation. Its application in research includes studying protein regulation mechanisms and investigating therapeutic strategies for various diseases. -
Ligands for E3 Ligase
Deoxy-thalidomide-OMe is an E3 ligase ligand that plays a crucial role in targeted protein degradation mechanisms. This compound is utilized in the synthesis of PROTAC LRRK2 Degrader-4, facilitating research in the modulation of LRRK2 activity, which has implications in neurodegenerative diseases. Its ability to selectively engage with E3 ligases makes it a valuable tool for advancing studies in protein homeostasis and therapeutic development. -
VHL Ligand
(S,R,R)-VH032 is a selective VHL ligand that facilitates targeted protein degradation through its interaction with the von Hippel-Lindau (VHL) E3 ubiquitin ligase complex. This compound serves as a crucial building block in the synthesis of PROTACs, specifically enabling the development of NCOA4 degrader-1. Its application in research highlights its potential for advancing studies in targeted protein degradation and therapeutic intervention strategies. -
Ligand for E3 Ligase
N-Demethylonalespib is an effective ligand for E3 ligase, playing a crucial role in ubiquitination pathways. This compound is instrumental in the synthesis of DDO3602, facilitating research into protein degradation and cellular regulation. Its application in cellular biology makes it a valuable tool for investigating E3 ligase-targeted therapies. -
Ligands for E3 Ligase
RA183 is a selective ligand for E3 ligases, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables the targeted degradation of specific proteins by harnessing the ubiquitin-proteasome system, making it a valuable tool in chemical biology and drug discovery. RA183 can be utilized in various research applications aimed at elucidating protein function and developing innovative therapeutic strategies. -
Ligand for E3 Ligase
(S,R,S)-AHPC-Ala is a ligand for E3 ubiquitin ligases, facilitating targeted protein degradation via the ubiquitin-proteasome pathway. This compound is instrumental in the synthesis of PROTAC SMARCA2/4-degrader-23, which is utilized in studies focused on the modulation of the SMARCA2 and SMARCA4 proteins. Its applications encompass research in cancer biology and therapeutic development, contributing to the advancement of targeted therapies.
