Catalog No.
Product Name
Application
Product Information
Citations
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Ligand for E3 Ligase
Pomalidomide-6-OH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating targeted protein degradation through the proteolysis-targeting chimera (PROTAC) approach. This compound is instrumental in research applications focused on the selective modulation of protein levels within cellular contexts, contributing to studies in cancer and other diseases. Pomalidomide-6-OH serves as a valuable tool for investigating the biochemical pathways regulated by CRBN. -
Lenalidomide Analog
3-(7-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a Lenalidomide analog that serves as a valuable tool in PROTAC research. This compound selectively modulates protein degradation pathways, making it instrumental in the development of targeted therapeutics. Its structural similarity to Lenalidomide allows for the exploration of novel therapeutic applications in oncology and immunology. -
Ligand for E3 Ligase
CRBN ligand-788 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand via a linker, enabling the formation of a proteolysis-targeting chimeric (PROTAC) molecule. CRBN ligand-788 is primarily utilized in research focused on targeted protein degradation and harnessing the ubiquitin-proteasome system for therapeutic interventions. -
Ligand for E3 Ligase
Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride is a ligand targeting cereblon (CRBN) within the E3 ubiquitin ligase complex. This compound facilitates the recruitment of CRBN, making it a valuable tool for the development of PROTACs (proteolysis-targeting chimeras) through linker conjugation. It holds potential applications in research related to targeted protein degradation and the study of protein homeostasis in various diseases, particularly in cancer. -
Ligand for E3 Ligase
CRBN ligand-661 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the targeted recruitment of the cereblon protein. This compound is designed for use in the development of PROTACs (Proteolysis Targeting Chimeras), linking to specific target proteins to promote their degradation via the ubiquitin-proteasome pathway. Its potential applications include studies in targeted protein degradation and the modulation of protein levels in various biological contexts. -
Ligand for E3 Ligase
Desamino lenalidomide-COOH is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the targeted regulation of protein degradation. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera), enabling the selective modulation of protein functions in cellular and in vivo studies. It is a valuable tool for research applications in protein homeostasis and therapeutic development. -
Ligand for E3 Ligase
(S)-Thalidomide 4-fluoride is a selective ligand for the cereblon (CRBN) E3 ligase. This compound is utilized in the synthesis of DeDPP4, making it a valuable tool in research related to protein degradation and the development of targeted therapeutics. Its interaction with the E3 ligase pathway underscores its potential applications in cellular biology and drug discovery initiatives. -
Ligand for E3 Ligase
C5 Lenalidomide-CH3 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to generate a PROTAC, thereby enabling targeted protein degradation. Its unique mechanism offers valuable applications in research focused on protein modulation and degradation pathways. -
Ligand for E3 Ligase
Desamino lenalidomide-5-CO is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker to facilitate the formation of proteolysis-targeting chimeras (PROTACs). Its application in protein degradation studies makes it a valuable tool for exploring therapeutic strategies in various diseases, including cancer. -
Lenalidomide Analog
3-(7-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a Lenalidomide analog targeting the ubiquitin-proteasome system. This compound exhibits notable biological activity in the development of PROTACs (proteolysis-targeting chimeras), providing a valuable tool for research into targeted protein degradation. Its structural features enhance the potential for therapeutic applications in oncology and related fields. -
Thalidomide Analogue
Thalidomide-CH2NH2 hydrochloride is a Thalidomide analogue characterized by a primary amine functionality. This compound demonstrates potential biological activity by modulating immune responses and influencing angiogenesis. It is suitable for research applications investigating mechanisms of action related to inflammatory diseases, cancer treatment, and teratogenic effects associated with Thalidomide derivatives. -
Ligands for E3 Ligase
Thalidomide-pyrrolidine is a ligand for E3 ligases, facilitating targeted protein degradation via the PROTAC technology. This compound is instrumental in the synthesis of PROTAC ARD-1676, which enables selective modulation of protein levels in cellular systems. Thalidomide-pyrrolidine is valuable for research applications focused on therapeutic interventions in various diseases by leveraging the ubiquitin-proteasome pathway. -
Ligands for E3 Ligase
3-(4-Bromo-2-fluorophenyl)piperidine-2,6-dione is an effective ligand for the CRBN-type E3 ubiquitin ligase, facilitating targeted protein degradation through the formation of PROTACs (Proteolysis Targeting Chimeras). This compound is instrumental in studies focused on ubiquitin-mediated proteolysis and can be utilized in various research applications aimed at elucidating protein function and regulation. Its unique structural features enable specific binding interactions that are crucial for the development of innovative therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-617 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN to target proteins. This compound can be conjugated to a ligand that binds to a specific target protein through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). CRBN ligand-617 is applicable in studies focused on targeted protein degradation and has significant potential in drug discovery and therapeutic development. -
Ligands for E3 Ligase
E3 Ligase Ligand 18 is a selective ligand for E3 ubiquitin ligases, facilitating the targeted degradation of proteins through the ubiquitin-proteasome system. When conjugated to a target protein via a linker, it forms a PROTAC (proteolysis-targeting chimera), which effectively induces ubiquitination and subsequent degradation of cancer-associated proteins. This reagent is valuable in research focused on protein degradation pathways and may contribute to therapeutic strategies for cancer treatment. -
E3 Ligase Ligand
Thalidomide-(2)piperidine is a potent E3 ligase ligand that plays a critical role in targeted protein degradation. This compound is valuable for the synthesis of proteolysis-targeting chimeras (PROTACs), facilitating the selective degradation of proteins of interest in cellular models. Its unique mechanism of action makes it a powerful tool in chemical biology and drug discovery research. -
E3 Ligase Ligand
Thalidomide-pyrrolidine hydrochloride is an E3 ligase ligand that serves as a key building block for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates targeted protein degradation by engaging with E3 ligases, offering a valuable tool for studies in protein regulation and the development of novel therapeutic strategies. Its application in chemical biology makes it an important reagent for researchers exploring targeted degradation pathways. -
Ligands for E3 Ligase
Cereblon inhibitor 1 is an isoindoline derivative that functions as a modulator of cereblon E3 ubiquitin ligase. This compound is designed to inhibit cerablon activity, making it a valuable tool for cancer research by disrupting protein homeostasis and influencing cell signaling pathways. Its application may extend to studying the therapeutic potential of targeting E3 ligases in various cancer models. -
Ligands for E3 Ligase
Lenalidomide-4-aminomethyl hydrochloride is a derivative of Lenalidomide that functions as a ligand for cereblon (CRBN), a component of the E3 ubiquitin ligase complex. This compound facilitates the recruitment of CRBN protein, enabling targeted protein degradation. It can be utilized as a building block in the development of proteolysis-targeting chimeras (PROTACs) for various therapeutic applications in cancer research and other disease models. -
CRBN Ligand
CRBN ligand-9 is a selective ligand targeting cereblon (CRBN) with a binding affinity (Ki) of 8.9 μM. This compound is designed for use in the synthesis of PROTACs (proteolysis targeting chimeras), facilitating the targeted degradation of specific proteins. CRBN ligand-9 serves as an essential tool for research in drug discovery and development, particularly in studies focused on targeted protein degradation mechanisms. -
E3 Ligase Ligand
E3 Ligase Ligand 51 functions as a ligand for the E3 ligase CRBN, facilitating targeted protein degradation through the synthesis of PROTACs, specifically BTK Degrader-12. This compound plays a crucial role in the research of protein homeostasis, allowing for the selective degradation of target proteins. Its application is significant in the study of various diseases, including cancer, by modulating protein levels in cellular contexts. -
VHL Ligand Variants
SJF-0661 is a variant of the von Hippel-Lindau (VHL) protein ligand that lacks the capacity for targeted degradation. Serving as an essential control reagent, it is useful for studies involving VHL ubiquitin ligase ligands. This compound is synthesized by inverting the stereocenter of the critical hydroxyproline moiety in the original VHL ligand, allowing researchers to evaluate the specific activities of VHL ligands in various biological contexts. -
VHL Ligand
VL285 Phenol is a phenol-based analog of VL285, serving as a ligand for the E3 ubiquitin ligase VHL. This compound enables the synthesis of HaloPROTAC3, facilitating the degradation of HaloTag7 fusion proteins with an IC50 of 0.34 μM. It is a valuable tool for research applications involving targeted protein degradation and the study of protein homeostasis in cellular systems. -
CRBN Ligand
CRBN ligand-187 is a potent CRBN-type E3 ubiquitin ligase ligand that plays a crucial role in the modulation of ubiquitination processes. This compound has been utilized for the synthesis of TQ-3959, facilitating research in targeted protein degradation and cellular signaling pathways. Its ability to engage the CRBN ligase offers valuable insights for studies involving protein homeostasis and therapeutic interventions in various diseases. -
Ligand for E3 Ligase
CRBN ligand-789 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound is designed for use in the development of PROTACs (proteolysis-targeting chimeras) by enabling the targeted degradation of specific proteins when linked to a target protein ligand. Its application is significant in chemical biology and therapeutic research, providing a valuable tool for studying protein regulation and degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-774 is a ligand specifically designed for the E3 ubiquitin ligase cereblon (CRBN). It effectively recruits the cereblon protein and can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. This compound is instrumental in research applications focusing on targeted protein degradation and the modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-206 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN for targeted ubiquitination. This compound can be conjugated with a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimeras). CRBN ligand-206 is instrumental in studies aimed at regulating protein degradation pathways and understanding ubiquitin-mediated processes in cellular functions. -
Ligand for E3 Ligase
5-Fluoro-lenalidomide is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand using a linker to create a proteolysis-targeting chimera (PROTAC). Its ability to mediate targeted protein degradation makes it a valuable tool in the study of protein homeostasis and therapeutic development. -
E3 Ligase Activator
Thalidomide-iodo is an iodo-substituted E3 ligase activator. It plays a crucial role in the ubiquitin-proteasome pathway, facilitating targeted protein degradation. Thalidomide-iodo can serve as a valuable intermediate for further chemical modifications, allowing researchers to explore novel derivatives in the study of protein regulation and cellular processes. This compound is essential for investigations into therapeutic strategies related to various diseases, including cancer and immune disorders. -
Ligand for E3 Ligase
Desamino lenalidomide-6-propyne is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC. Its applications include targeted protein degradation and modulation of cell signaling pathways for research in various biological contexts. -
Thalidomide Analog
Thalidomide-1-Me-5-NH2 is an aminated analog of Thalidomide, primarily targeting E3 ligase activation. This compound serves as a useful intermediate for the development of PROTAC (Proteolysis Targeting Chimera) molecules through amine derivatization. Researchers can utilize this reagent in studies focused on targeted protein degradation and related therapeutic applications. -
Thalidomide Analog
Deoxy-thalidomide-5-iodine is a Thalidomide analog that serves as a valuable tool in PROTAC (Proteolysis Targeting Chimeras) research. This compound is designed to facilitate targeted protein degradation by recruiting E3 ligases, enabling the selective elimination of specific proteins within cellular systems. Its unique structural modifications may enhance potency and efficacy in various biological assays, making it essential for advancing studies in targeted oncology and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-891 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to conjugate a target protein ligand through a linker, enabling the development of PROTAC molecules for targeted protein degradation studies. Its application is particularly relevant in drug discovery and the investigation of cellular pathways involving protein homeostasis. -
E3 Ligase Activator
Thalidomide 4-chloro is an E3 ligase activator that exhibits unique properties due to its chlorinated structure. This compound plays a significant role in promoting protein degradation pathways, making it valuable for research focused on modulating cellular processes. Additionally, Thalidomide 4-chloro serves as a versatile starting material for further derivatization through chlorine substitution, allowing for the exploration of novel analogs in chemical research. -
Ligand for E3 Ligase
Desamino lenalidomide-6-Br-5-F is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in targeted protein degradation assays. This compound can be conjugated to a target protein ligand using a linker to create a proteolysis-targeting chimera (PROTAC). Its versatile functionality makes it an essential tool for researchers investigating protein regulation and degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-884 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. It serves as a crucial tool for studies in protein regulation, cancer therapeutics, and other areas involving targeted protein modulation. -
Ligand for E3 Ligase
CRBN ligand-704 is a ligand for the E3 ubiquitin ligase cereblon (CRBN). It effectively recruits the CRBN protein for targeted protein degradation applications, facilitating the development of Proteolysis Targeting Chimeras (PROTACs). Its utility in research enables the selective modulation of protein levels, making it a valuable tool for studies in protein homeostasis and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-733 is a small molecule ligand targeting the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN, allowing for the targeted degradation of specific proteins when conjugated with a target protein ligand through a linker to create a PROTAC. This compound is valuable in research applications aimed at understanding protein function and developing protein degradation strategies in therapeutic contexts. -
Ligand for E3 Ligase
Desamino lenalidomide-7-F is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of cereblon to target proteins, allowing for the targeted degradation of specific intracellular proteins through the formation of PROTACs (Proteolysis Targeting Chimeras). This compound is valuable for researching protein regulation and therapeutic applications in oncology and other diseases. -
Ligand for E3 Ligase
CRBN ligand-838 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to effectively recruit the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC, enabling targeted degradation of specific proteins. CRBN ligand-838 is valuable for research applications in protein homeostasis and the study of targeted protein degradation pathways. -
Thalidomide Analog
Thalidomide-4-carbaldehyde is a Thalidomide analogue featuring an aldehyde functional group. This compound is known to recruit E3 ligases, facilitating the ubiquitination and subsequent proteolysis of target proteins, making it a valuable tool in studying protein degradation pathways. Its highly reactive aldehyde group engages in reductive amination reactions with amine nucleophiles, offering diverse applications in chemical biology and medicinal chemistry research. -
Ligand for E3 Ligase
Desamino lenalidomide-4-C-COOH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in targeted protein degradation applications. This compound can be conjugated to a target protein ligand through a linker, enabling the creation of Proteolysis Targeting Chimeras (PROTACs). Its utilization in research provides insights into protein regulation mechanisms and therapeutic strategies in diseases influenced by protein homeostasis. -
Thalidomide Analog
Thalidomide-5-carbaldehyde is a Thalidomide analog featuring an aldehyde functional group. It actively interacts with E3 ligases, facilitating the ubiquitination and degradation of specific target proteins, thereby contributing to cellular regulation. The aldehyde group exhibits high reactivity towards amine nucleophiles, enabling reductive amination and other chemical modifications, making it a valuable tool for research in protein degradation pathways and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-883 is a ligand that targets the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific protein partners. This compound can be utilized in the synthesis of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. CRBN ligand-883 serves as a valuable tool for research applications aimed at studying targeted protein degradation and modulatory effects in cellular processes. -
Thalidomide Analog
Thalidomide-1-Me,4-OH is an analogue of Thalidomide, featuring an additional methyl group on the glutarimide moiety. This modification abolishes its interaction with the E3 ubiquitin ligase, cereblon (CRBN), which is critical for the ubiquitination and subsequent proteolytic degradation of target proteins. Thalidomide itself is well-known for its immunomodulatory and anti-inflammatory properties, making Thalidomide-1-Me,4-OH a valuable tool for investigating the molecular mechanisms of CRBN-mediated drug action and cellular protein regulation in research applications. -
Ligands for E3 Ligase
CRBN ligand-47 is a potent ligand for the CRBN-type E3 ubiquitin ligase, facilitating targeted protein degradation through the formation of PROTACs (Proteolysis Targeting Chimeras). This compound exhibits effective recruitment of E3 ligase activity, making it valuable for research in protein homeostasis and therapeutic interventions in various diseases. Its role in modulating ubiquitin-mediated pathways underscores its utility in chemical biology and drug discovery applications. -
Ligand for E3 Ligase
CRBN ligand-618 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be connected to a target protein ligand through a linker, enabling the development of PROTACs (proteolysis-targeting chimeras). CRBN ligand-618 is valuable for research applications focused on targeted protein degradation and modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-882 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a suitable linker to create a proteolysis-targeting chimera (PROTAC). Its application is particularly relevant in targeted protein degradation research and therapeutic development. -
Ligand for E3 Ligase
N-Methyl-desamino lenalidomide-NH2 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), playing a crucial role in targeted protein degradation. This compound facilitates the recruitment of cereblon to specific target proteins, enabling the development of PROTACs (proteolysis-targeting chimeras) for precision research applications. It serves as a valuable tool for studying proteasomal degradation pathways and expanding the scope of targeted therapies in drug discovery. -
Ligand for E3 Ligase
CRBN ligand-225 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). Its utility in targeted protein degradation makes it a valuable tool in chemical biology research and drug discovery applications.
