Fig. 1 · Structure
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CRBN ligand-13
Ligands for E3 Ligase
CRBN ligand-13 acts as a ligand for the CRBN-type E3 ubiquitin ligase, facilitating targeted protein degradation via the PROTAC (Proteolysis Targeting Chimeras) approach. It plays a critical role in the development of novel therapeutic strategies for various diseases by enabling the selective elimination of specific proteins within cells. This compound is valuable for researchers focused on protein regulation and targeted drug development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 3050687-70-9 |
| Applications | Ligands for E3 Ligase |
| Formula | C11H9BrClNO2 |
| Molecular Weight | 302.55 |
| SMILES | O=C(C(C1=CC=CC(Br)=C1Cl)CC2)NC2=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.