Catalog No.
Product Name
Application
Product Information
Citations
-
NPFFR Antagonist
DP32 is a bifunctional compound that serves as an antagonist of the neuropeptide FF receptor (NPFFR) while simultaneously acting as an agonist at the mu-opioid receptor (MOP). This unique dual activity makes DP32 a valuable tool in analgesia-related research, offering insights into pain modulation pathways and potential therapeutic applications in pain management. Researchers can utilize DP32 to explore the interplay between opioid signaling and neuropeptide regulation in various biological contexts. -
NPFFR2 modulator
NPFFR2 modulator-1 is a selective modulator of the neuropeptide FF receptor 2 (NPFFR2). This compound influences various signaling pathways associated with pain modulation and may provide insights into neuroinflammatory responses. It is valuable for researchers investigating neuropeptide interactions and their roles in pain perception and related disorders. -
NPFF2R/1R Agonist
AC-099 is a selective agonist for the neuropeptide FF receptor 2 (NPFF2R) with an EC50 of 1189 nM and a partial agonist for NPFF1R, exhibiting an EC50 of 2370 nM. This compound demonstrates significant potential in modulating pain responses, as evidenced by its ability to attenuate spinal nerve ligation-induced hypersensitivity in rat models. AC-099 serves as a valuable tool in pain research and for exploring the roles of NPFF receptors in the central nervous system. -
NPSR Antagonist
ML154 is a selective non-peptide antagonist of the neuropeptide S receptor (NPSR), demonstrating efficient brain penetration. This compound effectively inhibits NPS-induced cellular responses, including calcium influx, cAMP accumulation, and ERK phosphorylation, with IC50 values of 36.5 nM, 22.1 nM, and 9.3 nM, respectively. ML154 is a valuable tool for investigating the role of NPSR in various physiological and pathological processes. -
NPSR Agonist
R06039-691 is an agonist of the neuropeptide S receptor (NPSR), exhibiting an EC50 of 93 nM. This compound is involved in the modulation of several biological functions, including arousal, stress and anxiety responses, memory processes, and food intake, through the activation of NPSR. Its ability to influence these physiological pathways makes R06039-691 a valuable tool for research in neurobiology and potential therapeutic applications in anxiety and related disorders. -
NPSR Agonist
R06039-641 is a potent neuropeptide S receptor (NPSR) agonist with an EC50 value of 169 nM. By activating NPSR, R06039-641 modulates various physiological processes, including arousal, stress and anxiety responses, memory formation, and appetite regulation. This compound is valuable for research focused on neurobiology and behavioral sciences. -
NPSR Agonist
R06039-693 is a neuropeptide S receptor (NPSR) agonist, exhibiting an EC50 value of 169 nM. By activating NPSR, R06039-693 plays a pivotal role in modulating several biological functions, including arousal, stress and anxiety responses, memory processes, and food intake regulation. This compound is valuable for researchers investigating neuropeptide signaling pathways and their implications in neurobiology and behavioral science. -
NPSR Agonist
R06039-696 is a selective agonist of the neuropeptide S receptor (NPSR) with an EC50 of 91 nM. This compound plays a significant role in modulating various biological functions, including arousal, stress and anxiety responses, memory processes, and appetite regulation. R06039-696 is valuable for research applications focused on neurobiology and stress-related disorders. -
NPSR1 Modulator
NPSR1 modulator-1 is a selective modulator of the neuropeptide S receptor 1 (NPSR1), influencing its signaling pathways. This compound exhibits potential biological activity in regulating stress response and anxiety-related behaviors. It is primarily utilized in research focusing on neuropharmacology and the development of therapeutic strategies for anxiety disorders. -
NPY Y1 Receptor Antagonist
BIBO3304 is a selective antagonist of the neuropeptide Y (NPY) Y1 receptor, exhibiting subnanomolar affinity with IC50 values of 0.38 nM for the human receptor and 0.72 nM for the rat receptor. This compound serves as a valuable tool for investigating the role of NPY signaling in various biological processes, including appetite regulation and anxiety-related behaviors. Its oral bioavailability makes it suitable for in vivo studies in pharmacological research and neurobiology. -
NPY Y1/NPFF Receptor Antagonist
BIBP3226 TFA is a potent and selective antagonist of the neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptors. It exhibits inhibition constants (Kis) of 1.1 nM, 79 nM, and 108 nM for the rat NPY Y1, human NPFF2, and rat NPFF receptors, respectively. BIBP3226 TFA is utilized in research focused on anxiety and neuropeptide signaling pathways, providing valuable insights into the role of these receptors in various biological processes. -
NPY Y1 Receptor Agonist
[Leu31,Pro34]-Neuropeptide Y (porcine) is a selective agonist of the neuropeptide Y Y1 receptor. This analog exhibits significant anxiolytic effects, making it a valuable tool for studying anxiety-related disorders. It is predominantly utilized in neuropharmacological research to explore the role of NPY in stress and anxiety modulation. -
GalR2 Antagonist
M871 is a selective antagonist of the galanin receptor type 2 (GalR2), demonstrating a Ki value of 13.1 nM for GalR2, with significantly lower affinity for GalR1 and GalR3. This compound has been shown to reduce IgE production and the density of B cells in tissues, effectively alleviating allergic rhinitis in murine models. Additionally, M871 may impede nerve invasion in salivary adenoid cystic carcinoma and mitigate myocardial ischemia-reperfusion injury, making it a valuable tool for investigating GalR2-related conditions, including epilepsy and pain. -
NPY Receptor Y2 Agonist
Neuropeptide Y (3-36) (human, rat) is an agonist of the Neuropeptide Y receptor Y2 (NPY Y2). This neuropeptide Y metabolite, generated by the action of dipeptidyl peptidase-4 (DPP4), has been shown to reduce the release of norepinephrine through its interaction with the Y2 receptor. It is primarily utilized in research related to neurophysiology and metabolic disorders, providing insights into pathways associated with appetite regulation and anxiety. -
GAL2 Agonist
M1145 is a chimeric peptide that serves as a selective agonist for the galanin receptor type 2 (GAL2) with a Ki of 6.55 nM. This compound demonstrates over 90-fold increased affinity for GAL2 compared to GAL1 (Ki=587 nM) and 76-fold greater affinity relative to GalR3 (Ki=497 nM). M1145 enhances signal transduction pathways activated by galanin, making it a valuable tool for research on galanin receptor signaling and its implications in various biological processes. -
GAL1 Agonist
M617 is a selective galanin receptor 1 (GAL1) agonist, exhibiting inhibition constants (Kis) of 0.23 nM and 5.71 nM for GAL1 and GAL2, respectively. This compound primarily targets GAL1 to promote GLUT4 expression, significantly enhancing GLUT4 content in the cardiac muscle of type 2 diabetic rats. M617 is useful in research focused on metabolic disorders and the modulation of glucose homeostasis. -
NPY Y5 Receptor Antagonist
NTNCB hydrochloride is a selective antagonist of the neuropeptide Y Y5 receptor, exhibiting a Ki of 8 nM for human Y5. This compound is valuable for investigating the role of NPY signaling in various physiological processes and disorders. Its ability to specifically inhibit Y5 receptor activity makes it a useful tool in both pharmacological studies and drug discovery related to metabolic and neuropsychiatric diseases. -
Galanin receptor Antagonist
Galanin Receptor Ligand M35 is a high-affinity antagonist targeting the galanin receptor, exhibiting a dissociation constant (Kd) of 0.1 nM. This compound demonstrates Ki values of 0.11 nM for the human galanin receptor type 1 and 2.0 nM for type 2, making it an effective tool for studying the role of galanin receptors in various physiological and pathological processes. It is widely applicable in research focused on neurobiology, pain modulation, and neuroendocrine regulation. -
Satiety Factor
CART(55-102)(human) is an endogenous peptide that acts as a satiety factor, effectively suppressing appetite. It is intricately linked with the regulation of energy balance through its interactions with leptin and neuropeptide Y. This reagent is valuable for research applications focused on obesity, appetite control, and metabolic disorders. -
NPYY2 Receptor Antagonist
CYM 9484 is a selective neuropeptide Y (NPY) Y2 receptor antagonist, demonstrating high potency with an IC50 value of 19 nM. This compound effectively inhibits Y2 receptor activity, making it a valuable tool for studying neuropeptide signaling pathways and the role of NPY in various physiological processes. CYM 9484 is relevant for research in neurobiology and metabolic disorders where modulation of the Y2 receptor may provide therapeutic insights. -
NPY Y2 Receptor Antagonist
SF 11 is a potent antagonist of the neuropeptide Y Y2 receptor, exhibiting an IC50 value of 199 nM. This compound demonstrates antidepressant-like activity, making it a valuable tool for research into mood disorders and neuropharmacology. Its ability to penetrate the blood-brain barrier enhances its application in studies related to central nervous system functions and therapeutic interventions. -
Galanin Receptor Agonist
Galnon TFA is a selective non-peptide agonist of the galanin GAL1 and GAL2 receptors, exhibiting binding affinities with Kis of 11.7 μM and 34.1 μM, respectively. This compound demonstrates notable anticonvulsant and anxiolytic properties, making it valuable for research applications involving neurological disorders and the modulation of anxiety. Galnon TFA serves as an important tool for studying the therapeutic potential of galanin receptor signaling in various biological contexts. -
NPFF Receptor Agonist
RFRP-1 (human) is a potent Neuropeptide FF (NPFF) receptor agonist that targets human gonadotropin-releasing hormone (GnRH) neurons and gonadotropes, effectively inhibiting gonadotropin release. This compound demonstrates high affinity for the NPFF receptors, with EC50 values of 0.0011 nM for NPFF2 and 29 nM for NPFF1. RFRP-1 (human) is valuable in research applications related to hormonal regulation and neuroendocrine signaling. -
NPY2R Agonist
Nisotirostide is a selective NPY2 receptor agonist that mimics the action of peptide YY (PYY). This compound has demonstrated the ability to inhibit appetite, making it a valuable tool for researching obesity and metabolic disorders such as diabetes. Its application in these areas may provide insights into therapeutic strategies for appetite regulation and weight management. -
NPY Y5 Receptor Antagonist
NPY5RA-972 is a potent and selective antagonist of the neuropeptide Y (NPY) Y5 receptor, effectively penetrating the central nervous system (CNS). This compound inhibits the feeding behavior mediated by NPY Y5 receptor activation, making it a valuable tool for research into appetite regulation and obesity-related studies. Its oral bioavailability further enhances its utility for in vivo applications in neuroscience and metabolic research. -
Human Galanin Fragment
Galanin (1-19), human is the bioactive fragment of the human neuropeptide galanin. This peptide plays a critical role in various physiological processes, including the regulation of hormone release, pain modulation, and the alteration of feeding behavior. Its diverse biological activities make it a valuable tool for research applications in neurobiology, endocrinology, and metabolic studies. -
Y2R Antagonist
SF-22 is a potent antagonist of the neuropeptide Y receptor (Y2R), exhibiting an IC50 value of 750 nM. This compound effectively penetrates the blood-brain barrier, making it relevant for investigations into neurological diseases. Its ability to modulate Y2R activity provides valuable insights into neurobiological processes and potential therapeutic applications. -
NPY Cardiac Receptor Antagonist
Neuropeptide Y (18-36) (porcine) serves as a competitive antagonist of neuropeptide Y (NPY) cardiac receptors. With an IC50 value of 158 nM and a Ki value of 140 nM, this compound effectively inhibits the binding of I-NPY to cardiac ventricular membranes in a concentration-dependent manner. It is a valuable reagent for research focused on the pathophysiology and therapeutic interventions in congestive heart failure. -
Galanin Receptor Antagonist
Galantide serves as a non-specific antagonist of galanin receptors, comprised of peptides derived from galanin and substance P. It effectively recognizes two distinct classes of galanin binding sites in the rat hypothalamus, with dissociation constants (KD) of less than 0.1 nM and approximately 6 nM. Galantide demonstrates dose-dependent antagonism (IC50 = 1.0 nM) of galanin-mediated inhibition on glucose-induced insulin secretion in mouse pancreatic islets. Additionally, it binds to a singular population of substance P receptors with a KD of around 40 nM, demonstrating its potential for investigating galanin signaling pathways and their physiological effects. -
GPR55 Ligand
L-α-lysophosphatidylinositol (Soy) sodium is a potent endogenous ligand for the GPR55 receptor. As a lysophospholipid and endocannabinoid neurotransmitter, it plays a crucial role in various signaling pathways. It is primarily utilized in research applications focusing on cannabinoid receptor modulation, cell signaling processes, and neurobiology studies. -
sGC Activator
BAY 60-2770 is a selective and orally active soluble guanylyl cyclase (sGC) activator that enhances sGC activity independent of nitric oxide. This compound exhibits significant antifibrotic properties, making it a valuable tool for research into fibrosis and related diseases. Its unique mechanism of action allows for exploration in various biological pathways associated with cardiovascular and respiratory health. -
Guanylate Cyclase-C Agonist
Plecanatide is a guanylate cyclase-C (GC-C) receptor agonist, functioning as an analogue of Uroguanylin. It effectively activates GC-C receptors, leading to the stimulation of cGMP synthesis, with an EC50 of 190 nM in T84 cell assays. Additionally, Plecanatide demonstrates anti-inflammatory activity in murine colitis models, making it useful for research into gastrointestinal disorders and related inflammatory conditions. -
sGC Inhibitor
LY83583 is a selective inhibitor of soluble guanylate cyclase (sGC), effectively modulating the cGMP signaling pathway. This compound demonstrates significant biological activity by inhibiting kinase activity associated with tumor cell proliferation, particularly through the induction of the Cdk inhibitor p21. LY83583 is applicable for research in various cancer types, including colorectal cancer, breast cancer, and melanoma, as well as in studies related to cardiovascular disease. -
sGC Activator
Ataciguat is a soluble guanylate cyclase (sGC) activator that functions independently of nitric oxide. It specifically activates the ferric heme-iron redox form of sGC, leading to increased production of cyclic GMP (cGMP). This compound demonstrates significant vasodilatory effects and is useful in research applications related to cardiovascular function and regulation of vascular tone. -
GC-C Agonist
Dolcanatide is an orally active agonist of guanylate cyclase-C (GC-C). This compound exhibits laxative, anti-nociceptive, and anti-inflammatory properties, making it suitable for various experimental applications. Dolcanatide is particularly relevant in research focused on inflammatory bowel disease. -
GC-A PAM
MCUF-651 is a positive allosteric modulator of the guanylyl cyclase A receptor (GC-A), exhibiting a binding affinity (KD) of 397 nM. This compound selectively enhances the interaction of atrial natriuretic peptide (ANP) with GC-A, leading to increased cGMP production in human cardiac, renal, and adipose tissues. Additionally, MCUF-651 demonstrates the ability to inhibit cardiomyocyte hypertrophy, making it a valuable tool for research in cardiovascular and metabolic pathways. -
pGC Agonist
Cenderitide is a potent agonist of particulate guanylyl cyclase receptors (pGC). This natriuretic peptide, composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP), activates pGC-A and pGC-B, leading to increased levels of the second messenger cGMP. Cenderitide effectively suppresses aldosterone production and helps preserve glomerular filtration rate (GFR) without causing a reduction in blood pressure. It is suitable for research applications focused on heart failure. -
Guanylate Cyclase Agonist
Linaclotide acetate is a potent and selective agonist of guanylate cyclase C, primarily involved in the regulation of intestinal fluid secretion. This compound enhances chloride and bicarbonate secretion, promoting gastrointestinal fluid accumulation and facilitating movement within the intestines. Linaclotide acetate is commonly utilized in research focused on gastrointestinal disorders, specifically for studying mechanisms and treatments related to constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation. -
Guanylate Cyclase Inhibitor
Guanylate cyclase-IN-1 is a potent inhibitor of guanylate cyclase, a crucial enzyme involved in the regulation of intracellular signaling pathways. This compound exhibits significant biological activity by modulating nitric oxide signaling, making it a valuable tool for the study of cardiovascular diseases. Its applications extend to investigating the physiological and pathological roles of guanylate cyclase in various biological processes. -
sGC Stimulator
BAY 41-8543 is a soluble guanylyl cyclase (sGC) stimulator that functions independently of nitric oxide (NO). It exhibits vasodilatory effects in both pulmonary and systemic vascular beds in rat models. Additionally, BAY 41-8543 demonstrates antiplatelet activity, making it a valuable tool for research in cardiovascular diseases. -
NPR-C Activator
NPR-C activator 1 is a potent agonist of the natriuretic peptide receptor C (NPR-C), exhibiting an EC50 of approximately 1 μM. This compound enhances the activity of C-type natriuretic peptide (CNP), which plays a crucial role in the regulation of vascular homeostasis. NPR-C activator 1 is suitable for research applications focused on cardiovascular function and the therapeutic potential of modulating NPR-C signaling. -
Guanylate Cyclase Activator
Prepro-ANF (56-92), human is a precursor of the atrial natriuretic factor and functions as a guanylate cyclase activator. This peptide enhances the activity of particulate guanylate cyclase within renal membranes and units, playing a critical role in the regulation of renal function and blood pressure homeostasis. Its application in research includes studies on cardiovascular and renal physiology, as well as investigations into natriuretic signaling pathways. -
Diguanylate Cyclases Inhibitor
Ebselen oxide is a selenone analogue that serves as a potent inhibitor of diguanylate cyclases (DGCs). By covalently modifying DGCs, it disrupts c-di-GMP-receptor interactions and subsequently decreases DGC activity. Additionally, Ebselen oxide demonstrates antibacterial properties by inhibiting alginate production in Pseudomonas aeruginosa, with an IC50 of 14 μM. It also exhibits inhibitory activity against various histone deacetylases (HDAC1 to HDAC9), with IC50 values ranging from 0.2 to 4.7 μM, making it useful for research involving epigenetic regulation. -
sGC Activator
(Rac)-MGV354 is a potent soluble guanylate cyclase (sGC) activator, exhibiting EC50 values of less than 0.5 nM in CHO cells and 5 nM in GTM-3 E cells. Its ability to stimulate sGC makes it a valuable tool for investigating nitric oxide signaling pathways and their role in various biological processes. This compound is suitable for research applications focused on cardiovascular function and related signaling mechanisms. -
Intestinal Guanylate Cyclase Activator
Guanylin (human) is a 15-amino acid peptide that functions as an activator of intestinal guanylate cyclase. It primarily regulates electrolyte and water transport in intestinal and renal epithelia via a cyclic GMP-dependent mechanism. This endogenous peptide plays a crucial role in maintaining fluid homeostasis and is vital in studies related to gastrointestinal function and renal physiology. Research applications include investigating gastrointestinal disorders and kidney function modulation. -
sGC Stimulator
BAY-747 is a soluble guanylate cyclase (sGC) stimulator that exhibits potent oral bioactivity and brain penetrance. It has been shown to reverse L-NAME-induced memory impairments, thereby enhancing cognitive performance in rats during the object location task (OLT). Additionally, BAY-747 effectively reduces blood pressure in both normotensive and spontaneously hypertensive rat models. Furthermore, it demonstrates therapeutic potential by improving skeletal muscle function in the Duchenne muscular dystrophy (DMD) mdx/mTRG2 mouse model, making it a valuable reagent for neurological and cardiovascular research. -
sGC Stimulator
CFM 1571 hydrochloride is a potent stimulator of soluble guanylate cyclase (sGC), with an EC50 of 5.49 μM and an IC50 of 2.84 μM. This enzyme plays a critical role in the signaling pathway activated by nitric oxide (NO), which is essential for various physiological processes. CFM 1571 hydrochloride is valuable for research investigating cardiovascular conditions and other diseases linked to sGC signaling. -
Vasodilator
Ipramidil is a potent vasodilator that primarily targets the coronary circulation. It is known to significantly enhance nitric oxide (NO) release and stimulate guanylate cyclase activity, leading to improved blood flow to the heart. Due to its biological activity, Ipramidil is valuable in research focused on cardiovascular function and the mechanisms of vasodilation. -
Guanylate Cyclase Activator
Mosliciguat is a potent guanylate cyclase activator that enhances nitric oxide signaling through the stimulation of soluble guanylate cyclase. This compound exhibits key biological activities, including vasodilation and reduced blood pressure, making it relevant for cardiovascular research. Mosliciguat is primarily utilized in studies assessing pulmonary hypertension and related disorders, providing valuable insights into endothelial function and smooth muscle relaxation. -
Soluble Guanylate Cyclase Activator
BI 703704 is a potent soluble guanylate cyclase (sGC) activator that enhances intracellular signaling pathways through increased cGMP levels. It has demonstrated efficacy in inhibiting the progression of diabetic nephropathy in the ZSF1 rat model, making it a valuable tool for studying renal complications associated with diabetes. This compound is useful for research on cardiovascular and metabolic diseases, particularly those involving sGC modulation.
