Fig. 1 · Structure
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Cenderitide
pGC Agonist
Cenderitide is a potent agonist of particulate guanylyl cyclase receptors (pGC). This natriuretic peptide, composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP), activates pGC-A and pGC-B, leading to increased levels of the second messenger cGMP. Cenderitide effectively suppresses aldosterone production and helps preserve glomerular filtration rate (GFR) without causing a reduction in blood pressure. It is suitable for research applications focused on heart failure.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 507289-11-4 |
| Applications | pGC Agonist |
| Formula | C158H263N49O50S3 |
| Molecular Weight | 3745.27 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.