Fig. 1 · Structure
Documents & Downloads
BAY-747
sGC Stimulator
BAY-747 is a soluble guanylate cyclase (sGC) stimulator that exhibits potent oral bioactivity and brain penetrance. It has been shown to reverse L-NAME-induced memory impairments, thereby enhancing cognitive performance in rats during the object location task (OLT). Additionally, BAY-747 effectively reduces blood pressure in both normotensive and spontaneously hypertensive rat models. Furthermore, it demonstrates therapeutic potential by improving skeletal muscle function in the Duchenne muscular dystrophy (DMD) mdx/mTRG2 mouse model, making it a valuable reagent for neurological and cardiovascular research.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 1609342-18-8 |
| Applications | sGC Stimulator |
| Formula | C22H26F2N4O2 |
| Molecular Weight | 416.46 |
| Synonyms | BAY 1165747 |
| SMILES | FC(C=CC=C1F)=C1COC2=CC(C)=CN3C2=NC(C)=C3C(NC[C@@](C)(N)CC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.