BAY-747 is a soluble guanylate cyclase (sGC) stimulator that exhibits potent oral bioactivity and brain penetrance. It has been shown to reverse L-NAME-induced memory impairments, thereby enhancing cognitive performance in rats during the object location task (OLT). Additionally, BAY-747 effectively reduces blood pressure in both normotensive and spontaneously hypertensive rat models. Furthermore, it demonstrates therapeutic potential by improving skeletal muscle function in the Duchenne muscular dystrophy (DMD) mdx/mTRG2 mouse model, making it a valuable reagent for neurological and cardiovascular research.
BAY-747 is a soluble guanylate cyclase (sGC) stimulator that exhibits potent oral bioactivity and brain penetrance. It has been shown to reverse L-NAME-induced memory impairments, thereby enhancing cognitive performance in rats during the object location task (OLT). Additionally, BAY-747 effectively reduces blood pressure in both normotensive and spontaneously hypertensive rat models. Furthermore, it demonstrates therapeutic potential by improving skeletal muscle function in the Duchenne muscular dystrophy (DMD) mdx/mTRG2 mouse model, making it a valuable reagent for neurological and cardiovascular research.
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