Fig. 1 · Structure
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Plecanatide
Guanylate Cyclase-C Agonist
Plecanatide is a guanylate cyclase-C (GC-C) receptor agonist, functioning as an analogue of Uroguanylin. It effectively activates GC-C receptors, leading to the stimulation of cGMP synthesis, with an EC50 of 190 nM in T84 cell assays. Additionally, Plecanatide demonstrates anti-inflammatory activity in murine colitis models, making it useful for research into gastrointestinal disorders and related inflammatory conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 467426-54-6 |
| Applications | Guanylate Cyclase-C Agonist |
| Formula | C65H104N18O26S4 |
| Molecular Weight | 1681.89 |
| SMILES | N(C([C@@H](NC([C@@H](NC([C@H](CC(N)=O)N)=O)CC(O)=O)=O)CCC(O)=O)=O)[C@@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@]2(C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@](CSSC1)(C(=O)N[C@@]([C@@H](C)O)(C(=O)NCC(=O)N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CSSC2)[H])[H])[H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.