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Plecanatide

Catalog No.: A60860
Guanylate Cyclase-C Agonist
Plecanatide is a guanylate cyclase-C (GC-C) receptor agonist, functioning as an analogue of Uroguanylin. It effectively activates GC-C receptors, leading to the stimulation of cGMP synthesis, with an EC50 of 190 nM in T84 cell assays. Additionally, Plecanatide demonstrates anti-inflammatory activity in murine colitis models, making it useful for research into gastrointestinal disorders and related inflammatory conditions.
Plecanatide 467426-54-6 Guanylate Cyclase-C Agonist
Grouped product items
Size Price Stock Qty
1mg
$60.00
In stock
5mg
$155.00
In stock
10mg
$265.00
In stock
25mg
$520.00
In stock
50mg
$720.00
In stock
100mg
$945.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPlecanatide is a guanylate cyclase-C (GC-C) receptor agonist, functioning as an analogue of Uroguanylin. It effectively activates GC-C receptors, leading to the stimulation of cGMP synthesis, with an EC50 of 190 nM in T84 cell assays. Additionally, Plecanatide demonstrates anti-inflammatory activity in murine colitis models, making it useful for research into gastrointestinal disorders and related inflammatory conditions.
Product Information
Catalog NumA60860
FormulaC65H104N18O26S4
Molecular Weight1681.89
CAS Number467426-54-6
SequenceAsn-Asp-Glu-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu (Disulfide bridge: Cys4-Cys12; Cys7-Cys15)
Sequence shorteningNDECELCVNVACTGCL (Disulfide bridge: Cys4-Cys12; Cys7-Cys15)
SMILESN(C([C@@H](NC([C@@H](NC([C@H](CC(N)=O)N)=O)CC(O)=O)=O)CCC(O)=O)=O)[C@@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@]2(C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@](CSSC1)(C(=O)N[C@@]([C@@H](C)O)(C(=O)NCC(=O)N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CSSC2)[H])[H])[H]
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GPCR/G Protein > Guanylate Cyclase