M1145 is a chimeric peptide that serves as a selective agonist for the galanin receptor type 2 (GAL2) with a Ki of 6.55 nM. This compound demonstrates over 90-fold increased affinity for GAL2 compared to GAL1 (Ki=587 nM) and 76-fold greater affinity relative to GalR3 (Ki=497 nM). M1145 enhances signal transduction pathways activated by galanin, making it a valuable tool for research on galanin receptor signaling and its implications in various biological processes.
M1145 is a chimeric peptide that serves as a selective agonist for the galanin receptor type 2 (GAL2) with a Ki of 6.55 nM. This compound demonstrates over 90-fold increased affinity for GAL2 compared to GAL1 (Ki=587 nM) and 76-fold greater affinity relative to GalR3 (Ki=497 nM). M1145 enhances signal transduction pathways activated by galanin, making it a valuable tool for research on galanin receptor signaling and its implications in various biological processes.
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