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M871

Catalog No.: A62190
GalR2 Antagonist
M871 is a selective antagonist of the galanin receptor type 2 (GalR2), demonstrating a Ki value of 13.1 nM for GalR2, with significantly lower affinity for GalR1 and GalR3. This compound has been shown to reduce IgE production and the density of B cells in tissues, effectively alleviating allergic rhinitis in murine models. Additionally, M871 may impede nerve invasion in salivary adenoid cystic carcinoma and mitigate myocardial ischemia-reperfusion injury, making it a valuable tool for investigating GalR2-related conditions, including epilepsy and pain.
M871 908844-75-7 GalR2 Antagonist
Grouped product items
Size Price Stock Qty
1mg
$120.00
In stock
5mg
$305.00
In stock
10mg
$485.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionM871 is a selective antagonist of the galanin receptor type 2 (GalR2), demonstrating a Ki value of 13.1 nM for GalR2, with significantly lower affinity for GalR1 and GalR3. This compound has been shown to reduce IgE production and the density of B cells in tissues, effectively alleviating allergic rhinitis in murine models. Additionally, M871 may impede nerve invasion in salivary adenoid cystic carcinoma and mitigate myocardial ischemia-reperfusion injury, making it a valuable tool for investigating GalR2-related conditions, including epilepsy and pain.
Product Information
Catalog NumA62190
FormulaC108H163N27O28
Molecular Weight2287.61
CAS Number908844-75-7
SequenceH2N-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Glu-His-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2
Sequence shorteningWTLNSAGYLLGPEHPPPALALA-NH2
SMILESC(=O)(N1[C@H](C(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)C)=O)CC(C)C)=O)C)=O)CC(C)C)=O)C)=O)CCC2)CCC1)[C@H]3N(C([C@H](CC4=CN=CN4)NC([C@@H](NC(=O)[C@H]5N(C(CNC([C@@H](NC([C@@H](NC([C@H](CC6=CC=C(O)C=C6)NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC=7C=8C(NC7)=CC=CC8)N)=O)[C@@H](C)O)=O)CC(C)C)=O)CC(N)=O)=O)CO)=O)C)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)CCC5)CCC(O)=O)=O)=O)CCC3
SynonymsGalanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide
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GPCR/G Protein > NPY receptor