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M617

Catalog No.: A62193
GAL1 Agonist
M617 is a selective galanin receptor 1 (GAL1) agonist, exhibiting inhibition constants (Kis) of 0.23 nM and 5.71 nM for GAL1 and GAL2, respectively. This compound primarily targets GAL1 to promote GLUT4 expression, significantly enhancing GLUT4 content in the cardiac muscle of type 2 diabetic rats. M617 is useful in research focused on metabolic disorders and the modulation of glucose homeostasis.
M617 860790-38-1 GAL1 Agonist
Grouped product items
Size Price Stock Qty
1mg
$115.00
In stock
5mg
$300.00
In stock
10mg
$520.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionM617 is a selective galanin receptor 1 (GAL1) agonist, exhibiting inhibition constants (Kis) of 0.23 nM and 5.71 nM for GAL1 and GAL2, respectively. This compound primarily targets GAL1 to promote GLUT4 expression, significantly enhancing GLUT4 content in the cardiac muscle of type 2 diabetic rats. M617 is useful in research focused on metabolic disorders and the modulation of glucose homeostasis.
Product Information
Catalog NumA62193
FormulaC112H161N29O28
Molecular Weight2361.65
CAS Number860790-38-1
SequenceGly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Pro-Pro-Gly-Phe-Ser-Pro-NH2
Sequence shorteningGWTLNSAGYLLGPQPPGFSPFR-NH2
SMILESC([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@H](C(NCC(=O)N2[C@H](C(N[C@H](C(=O)N3[C@H](C(=O)N4[C@H](C(NCC(N[C@@H](CC5=CC=CC=C5)C(N[C@H](C(=O)N6[C@H](C(N[C@@H](CC7=CC=CC=C7)C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)=O)CCC6)CO)=O)=O)=O)CCC4)CCC3)CCC(N)=O)=O)CCC2)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)C)=O)CO)=O)CC(N)=O)=O)CC(C)C)=O)[C@@H](C)O)=O)NC(CN)=O)C=8C=9C(NC8)=CC=CC9
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GPCR/G Protein > NPY receptor