Fig. 1 · Structure
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Linaclotide acetate
Guanylate Cyclase Agonist
Linaclotide acetate is a potent and selective agonist of guanylate cyclase C, primarily involved in the regulation of intestinal fluid secretion. This compound enhances chloride and bicarbonate secretion, promoting gastrointestinal fluid accumulation and facilitating movement within the intestines. Linaclotide acetate is commonly utilized in research focused on gastrointestinal disorders, specifically for studying mechanisms and treatments related to constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 851199-60-5 |
| Applications | Guanylate Cyclase Agonist |
| Formula | C61H83N15O23S6 |
| Molecular Weight | 1586.79 |
| SMILES | C(C)(O)=O.O=C1N2[C@@](CCC2)(C(=O)N[C@@H](C)C(=O)N[C@@]3(C(=O)N[C@@]([C@@H](C)O)(C(=O)NCC(=O)N[C@H](C(N[C@@H](CC4=CC=C(O)C=C4)C(O)=O)=O)CSSC[C@]5(C(=O)N[C@](C(=O)N[C@H]1CC(N)=O)(CSSC[C@H](N)C(=O)N[C@@](CSSC3)(C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC6=CC=C(O)C=C6)C(=O)N5)[H])[H])[H])[H])[H])[H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.