Fig. 1 · Structure
Documents & Downloads
MCUF-651
GC-A PAM
MCUF-651 is a positive allosteric modulator of the guanylyl cyclase A receptor (GC-A), exhibiting a binding affinity (KD) of 397 nM. This compound selectively enhances the interaction of atrial natriuretic peptide (ANP) with GC-A, leading to increased cGMP production in human cardiac, renal, and adipose tissues. Additionally, MCUF-651 demonstrates the ability to inhibit cardiomyocyte hypertrophy, making it a valuable tool for research in cardiovascular and metabolic pathways.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 2747162-85-0 |
| Applications | GC-A PAM |
| Formula | C17H22F2N4OS |
| Molecular Weight | 368.44 |
| SMILES | O=C(C1CN(CCC1)CCN(C)C)NC2=NC3=C(S2)C=C(F)C=C3F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.