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Proteases

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Items 51-100 of 418

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Catalog No.
Product Name
Application
Product Information
Product Citation
  1. A11369
    CPA inhibitor

    CPA inhibitor

    CPA inhibitor is a potent inhibitor for carboxypeptidase A (CPA).
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  2. A11378
    Saquinavir

    HIV Protease Inhibitor

    Saquinavir is a protease inhibitor. Proteases are enzymes that cleave protein molecules into smaller fragments. Saquinavir inhibits both HIV-1 and HIV-2 proteases.
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  3. A11390
    DMP 777

    HLE inhibitor

    DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.
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  4. A11394
    Emricasan

    Caspase inhibitor

    Emricasan is a first-in-class caspase inhibitor in clinical trials for the treatment of liver diseases.
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  5. A11466
    Cathepsin Inhibitor 1

    Cathepsin Inhibitor

    Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.
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  6. A11470
    NSC 95397

    Phosphatase inhibitor

    NSC 95397 is a selective and effective dual-specificity, quinone-based phosphatase inhibitor.
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  7. A11499
    MLN4924 (HCL Salt)

    NAE Inhibitor

    NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival.
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  8. A11504
    Nelfinavir

    HIV-1 protease inhibitor

    Nelfinavir is a potent and orally bioavailable human immunodeficiency virus HIV-1 protease inhibitor (Ki=2 nM) and is widely prescribed in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection.
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  9. A11506
    Narlaprevir

    NS3 protease inhibitor

    Narlaprevir is a potent, selective, orally bioavailable NS3 protease inhibitor(Ki=6 nM; EC90=40 nM)
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  10. A11509
    NBD-557

    HIV-1 inhibitor

    NBD-557 is a potentially HIV-1 inhibitor.
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  11. A11510
    Nesbuvir

    HCV Polymerase Inhibitor

    HCV-796 is a selectively inhibitor of hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.
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  12. A11519
    PSI-6130

    HCV Nucleoside Inhibitor

    PSI-6130(R 1656) is a Hepatitis C Virus Nucleoside Inhibitor.
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  13. A11529
    Sofosbuvir (PSI-7977)

    HCV Nucleotide Inhibitor

    PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM).
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  14. A11530
    PSI-6206

    HCV RNA polymerase inhibitor

    PSI-6206 is the deaminated derivative of PSI-6130, which is a potent inhibitor of hepatitis C virus (HCV) replication in the subgenomic HCV reolicon system.
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  15. A11539
    Mericitabine

    HCV NS5B polymerase inhibitor

    Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.
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  16. A11540
    R-1479

    HCV replication inhibitor

    R-1479 is a specific inhibitor of HCV replication in the HCV subgenomic replicon system (IC50=1.28 μM).
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  17. A11570
    Saquinavir Mesylate

    HIV Protease Inhibitor

    Saquinavir mesylate is an HIV Protease Inhibitor used in antiretroviral therapy.
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  18. A11580
    Simeprevir

    HCV NS3/4A protease inhibitor

    Simeprevir is a potent inhibitor of HCV NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM).
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  19. A11583
    Tegobuvir (GS-9190)

    NS5B polymerase inhibitor

    Tegobuvir (GS-9190 is a non-nucleoside NS5B polymerase inhibitor.
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  20. A11597
    LB-100

    PP2A inhibitor

    LB-100 is a small-molecular protein phosphatase 2A(PP2A)inhibitor with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.
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  21. A11600
    Vaniprevir

    HCV NS3/4A protease inhibitor

    Vaniprevir is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A protease.
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  22. A11601
    MG-115

    Reversible Proteasome Inhibitor

    MG-115 is a potent, reversible peptide aldehyde inhibitor of proteasome chymotrypsin-like and caspase-like activities. It induces p53 dependent apoptosis.
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  23. A11674
    Epalrestat

    aldose reductase inhibitor

    Epalrestat is an aldose reductase inhibitor.
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  24. A11774
    Argatroban

    Thrombin inhibitor

    Argatroban is an anticoagulant that is a small molecule direct thrombin inhibitor.
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  25. A11790
    Fidarestat (SNK-860)

    Aldose reductase inhibitor

    Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease.
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  26. A11791
    Calyculin A

    PP2A inhibitor

    Calyculin A is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM.
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  27. A11853
    Darunavir Ethanolate (Prezista)

    HIV protease inhibitor

    Darunavir Ethanolate (Prezista) is an HIV protease inhibitor.
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  28. A11901
    PMSF

    Serine/cysteine protease inhibitor

    PMSF is an irreversible serine/cysteine protease inhibitor.
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  29. A12020
    Balicatib

    Cathepsin K inhibitor

    Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys.
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  30. A12067
    Voxilaprevir

    HCV NS3/4A protease inhibitor

    Voxilaprevir (GS-9857) is a fluorinated macrocyclic hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease inhibitor with potent in vitro antiviral activity against genotypes 1-6 HCV and broad coverage of NS3/4A protease polymorphisms. GS-9857 improves coverage against commonly encountered NS3 resistance-associated variants (RAVs).
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  31. A12154
    RWJ-445167

    dual inhibitor of thrombin and factor Xa

    RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with Ki of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.
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  32. A12220
    MG-262

    Proteasome inhibitor

    MG-262, a boronic peptide acid, is a potent proteasome inhibitor that selectively and reversibly inhibits the chymotryptic activity of the proteasome.
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  33. A12242
    ZED-1227

    transglutaminase 2 (TG2) inhibitor

    ZED-1227 is a specific and oral transglutaminase 2 (TG2) inhibitor, which can block inflammation-induced TG2 expression and activity. ZED-1227 is a promising agent for the treatment of celiac disease (CeD).
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  34. A12254
    Proteasome-IN-1

    proteasome inhibitor

    Proteasome-IN-1 is a proteasome inhibitor extracted from patent WO 2013142376 A1.
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  35. A12255
    L-690330

    IMPase inhibitor

    L-690330 is a competitive inhibitor of inositol monophosphatase (IMPase) with Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively.
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  36. A12278
    PF-02575799

    MTP inhibitor

    PF-02575799 is a microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.77±0.29 nM.

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  37. A12287
    RA190

    Proteasome inhibitor

    RA190, a bis-benzylidine piperidon, inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.
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  38. A12373
    Z-VAD-FMK

    Pan Caspase Inhibitor

    Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
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  39. A12374
    VCH-916

    HCV NS5B polymerase inhibitor

    VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor.
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  40. A12444
    BMS 299897

    γ-secretase inhibitor

    BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo.
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  41. A12487
    L-873724

    Cathepsin K inhibitor

    L-873724 is a potent, orally bioavailable, selective and reversible non-basic cathepsin K inhibitor.
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  42. A12499
    MBM-17

    Nek2 inhibitor

    MBM-17 (compound 42c) is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM.
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  43. A12509
    Ximelagatran

    Thrombin inhibitor

    Ximelagatran is an anticoagulant that has been investigated extensively as a replacement for warfarin that would overcome the problematic dietary, drug interaction, and monitoring issues associated with warfarin therapy.
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  44. A12510
    MBM-55

    Nek2 inhibitor

    MBM-55 (compound 42g) is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 1 nM.
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  45. A12528
    Vildagliptin

    DPP-IV Inhibitor

    Vildagliptin is a dipeptidyl peptidase-4 (CD26) inhibitor.
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  46. A12583
    Fosamprenavir

    HIV protease inhibitor

    Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease.
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  47. A12611
    Z-VEID-FMK

    Caspase-6 inhibitor

    Z-VEID-FMK is the specific recognition sequence for caspase-6/Mch2. Z-VEID-FMK is a synthetic peptide that irreversibly inhibits activity of VEID-dependent caspases (e.g., caspase-6). The inhibitor is designed as a methyl ester to facilitate cell permeability.
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  48. A12637
    Z-VDVAD-FMK

    Caspase-2 inhibitor

    Z-VDVAD-FMK is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes.
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  49. A12653
    ONX-0914

    Immunoproteasome inhibitor

    ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome.
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  50. A12697
    Z-DQMD-FMK

    Caspase-3 inhibitor

    Z-DQMD-FMK is a synthetic peptide that irreversibly inhibits the activity of Caspase-3.
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Items 51-100 of 418

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