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ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome.
Targets
| LMP7 (Cell-free assay) | ||||
| ~10 nM |
| In vitro | DMSO | 100 mg/mL (172.21 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 100 mg/mL (172.21 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.22 mL | 86.11 mL | 172.21 mL |
| 0.5 mM | 3.44 mL | 17.22 mL | 34.44 mL |
| 1 mM | 1.72 mL | 8.61 mL | 17.22 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.44 mL |
*The above data is based on the productmolecular weight 580.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A12653 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 580.67 |
| Formula | C31H40N4O7 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 960374-59-8 |
| Synonyms | ONX0914, ONX 0914, PR-957 |
| SMILES | C[[email protected]@H](C(=O)N[[email protected]@H](CC1=CC=C(C=C1)OC)C(=O)N[[email protected]@H](CC2=CC=CC=C2)C(=O)[[email protected]]3(CO3)C)NC(=O)CN4CCOCC4 |
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Contact information
United StatesAdooq Bioscience
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Email: [email protected]
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