ONX-0914

Catalog No.: A12653
Immunoproteasome inhibitor
ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome.
Grouped product items
Product Name Price Stock Qty
ONX-0914 5mg
Special Price $80.00 Regular Price $100.00
In stock
ONX-0914 10mg
Special Price $120.00 Regular Price $150.00
In stock
ONX-0914 25mg
Special Price $240.00 Regular Price $300.00
In stock
ONX-0914 50mg
Special Price $360.00 Regular Price $450.00
In stock
ONX-0914 10mM * 1mL in DMSO
Special Price $112.00 Regular Price $140.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's ONX-0914 has been cited by 4 publications
  • Yuki Sasaki, .et al. , JCI Insight, 2022, Apr 8;7(7) PMID: 35393946
  • Ming-Shu Mo, .et al. , Transl Neurodegener, 2018, 7: 19 PMID: 30128145
  • Ohkusu-Tsukada K, .et al. , Int Arch Allergy Immunol, 2018, 176(2):91-100 PMID: 29669333
  • Arimochi H, .et al. , Sci Rep, 2016, May 26;6:26791 PMID: 27225296
  • Biological Activity
    Discription ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome.
    Targets
    Target Value
    Product Information
    Catalog Num A12653
    Formula C31H40N4O7
    Molecular Weight 580.67
    CAS Number 960374-59-8
    SMILES C[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)OC)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)[C@]3(CO3)C)NC(=O)CN4CCOCC4
    Synonyms ONX0914, ONX 0914, PR-957
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 87 mg/mL (149.82 mM)
    Water Insoluble
    Ethanol 87 mg/mL (149.82 mM)
    In vivo 2% DMSO+castor oil 9 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 17.22 mL 86.11 mL 172.21 mL
    0.5 mM 3.44 mL 17.22 mL 34.44 mL
    1 mM 1.72 mL 8.61 mL 17.22 mL
    5 mM 0.34 mL 1.72 mL 3.44 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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