ONX-0914

Catalog No.: A12653

Immunoproteasome inhibitor

ONX-0914

ONX-0914 Chemical Structure

CAS NO. 960374-59-8

ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $90.00

Special Price $72.00

10 mg

Regular Price: $160.00

Special Price $128.00

25 mg

Regular Price: $320.00

Special Price $256.00

50 mg

Regular Price: $550.00

Special Price $440.00

10mM * 1mL in DMSO
$164.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome.
Targets
LMP7 (Cell-free assay)
~10 nM
In vitro DMSO 100 mg/mL (172.21 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (172.21 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.22 mL 86.11 mL 172.21 mL
0.5 mM 3.44 mL 17.22 mL 34.44 mL
1 mM 1.72 mL 8.61 mL 17.22 mL
5 mM 0.34 mL 1.72 mL 3.44 mL

*The above data is based on the productmolecular weight 580.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A12653
Actions Inhibitor
M. Wt 580.67
Formula C31H40N4O7
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 960374-59-8
Synonyms ONX0914, ONX 0914, PR-957
SMILES C[[email protected]@H](C(=O)N[[email protected]@H](CC1=CC=C(C=C1)OC)C(=O)N[[email protected]@H](CC2=CC=CC=C2)C(=O)[[email protected]]3(CO3)C)NC(=O)CN4CCOCC4

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