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Publications citing Adooq Products
ONX-0914 Citations (3)
- Ming-Shu Mo,et al. Dopaminergic neurons show increased low-molecular-mass protein 7 activity induced by 6-hydroxydopamine in vitro and in vivo, Transl Neurodegener, 2018, 7: 19 30128145
- Ohkusu-Tsukada K,et al. The Role of Proteasome Inhibitor MG132 in 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis in NC/Nga Mice, Int Arch Allergy Immunol, 2018, 176(2):91-100 29669333
- Arimochi H,et al. Differentiation of preadipocytes and mature adipocytes requires PSMB8, Sci Rep, 2016, May 26;6:26791 27225296
Chemical Information
| Catalog Num | A12653 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 580.67 |
| Formula | C31H40N4O7 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 960374-59-8 |
| Synonyms | ONX0914, ONX 0914, PR-957 |
| SMILES code | C[[email protected]@H](C(=O)N[[email protected]@H](CC1=CC=C(C=C1)OC)C(=O)N[[email protected]@H](CC2=CC=CC=C2)C(=O)[[email protected]]3(CO3)C)NC(=O)CN4CCOCC4 |
| Chemical Name | (S)-3-(4-methoxyphenyl)-N-((S)-1-((S)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)propanamido)propanamide |
Description |
ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome. | ||||||||||
Targets |
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| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (172.21 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 100 mg/mL (172.21 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.22 mL | 86.11 mL | 172.21mL |
| 0.5 mM | 3.44 mL | 17.22 mL | 34.44 mL |
| 1 mM | 1.72 mL | 8.61 mL | 17.22 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.44 mL |
*The above data is based on the productmolecular weight 580.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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