Voxilaprevir

Catalog No.: A12067

HCV NS3/4A protease inhibitor

Voxilaprevir

Voxilaprevir Chemical Structure

CAS NO. 1535212-07-7

Voxilaprevir (GS-9857) is a fluorinated macrocyclic hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease inhibitor with potent in vitro antiviral activity against genotypes 1-6 HCV and broad coverage of NS3/4A protease polymorphisms. GS-9857 improves coverage against commonly encountered NS3 resistance-associated variants (RAVs).

Availability: In stock

Package Price Qty
1 mg

Regular Price: $320.00

Special Price $256.00

5 mg

Regular Price: $960.00

Special Price $768.00

10 mg

Regular Price: $1,600.00

Special Price $1,280.00

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Biological Activity

Voxilaprevir (GS-9857) is a fluorinated macrocyclic hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease inhibitor with potent in vitro antiviral activity against genotypes 1-6 HCV and broad coverage of NS3/4A protease polymorphisms. GS-9857 improves coverage against commonly encountered NS3 resistance-associated variants (RAVs).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 11.51 mL 57.54 mL 115.08 mL
0.5 mM 2.3 mL 11.51 mL 23.02 mL
1 mM 1.15 mL 5.75 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL

*The above data is based on the productmolecular weight 868.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12067
Actions Inhibitor
CAS No. 1535212-07-7
Formula C40H52F4N6O9S
M. Wt 868.93
Purity >98%
Synonyms GS-9857, GS9857, GS 9857
SMILES O=C([[email protected]]1N(C([[email protected]@H](NC(O[[email protected]]2[[email protected]]3C2)=O)C(C)(C)C)=O)C[[email protected]@](OC4=NC5=CC(OC)=CC=C5N=C4C(F)(CCCC3)F)([H])[[email protected]]1CC)N[[email protected]]6([[email protected]](C(F)F)C6)C(NS(=O)(C7(CC7)C)=O)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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