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Fig. 1 · Structure
Cat. No.
A11600
CAS No.
923590-37-8
Formula
C38H55N5O9S
Mol. Weight
757.95

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Vaniprevir

Cat. No. A11600 CAS 923590-37-8

HCV NS3/4A protease inhibitor

Vaniprevir is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A protease.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
Huh-7 EC50 0.27 nM Antiviral activity against HCV1b harboring Q80Q polymorphism in NS3 protease gene infected in human Huh7/Lunet cells assessed as inhibition of viral replication after 3 days by luciferase based transient-transfection assay [PMID: 20855726]
Huh-7 EC50 0.41 nM Antiviral activity against HCV1b harboring Q80K polymorphism in NS3 protease gene infected in human Huh7/Lunet cells assessed as inhibition of viral replication after 3 days by luciferase based transient-transfection assay [PMID: 20855726]
Huh-7 EC50 0.7 nM Antiviral activity against HCV1b Con1 harboring NS3 protease gene infected in human Huh7/Lunet cells assessed as inhibition of viral replication after 3 days by luciferase based transient-transfection assay [PMID: 20855726]
Huh-7 IC50 19 nM Antiviral activity against HCV Con1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs by replicon assay in presence of 50% normal human serum [PMID: 20163176]
Huh-7 IC50 19 nM Antiviral activity against Hepatitis C virus (isolate Con1) genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 50% NHS [PMID: 24900473]
Huh-7 IC50 3 nM Antiviral activity against HCV Con1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs by replicon assay in presence of 10% fetal bovine serum [PMID: 20163176]
Huh-7 EC50 5 nM Antiviral activity against HCV 1B infected in human Huh7 cells by firefly luciferase reporter gene assay [PMID: 20541424]
Huh-7 IC50 9 nM Antiviral activity against HCV JFH-1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs by replicon assay in presence of 10% fetal bovine serum [PMID: 20163176]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 923590-37-8
Applications HCV NS3/4A protease inhibitor
Formula C38H55N5O9S
Molecular Weight 757.95
Synonyms MK-7009
SMILES
CCC1CC1(C(=O)NS(=O)(=O)C2CC2)NC(=O)C3CC4CN3C(=O)C(NC(=O)OCC(CCCCC5=C6CN(CC6=CC=C5)C(=O)O4)(C)C)C(C)(C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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