BMS 299897

Catalog No.: A12444

γ-secretase inhibitor

BMS 299897

BMS 299897 Chemical Structure

CAS NO. 290315-45-6

BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo.

Availability: In stock

Package Price Qty
10 mg
$110.00
25 mg
$220.00
50 mg
$300.00
100 mg
$680.00
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  • Chao Liu, .et al. APP upregulation contributes to retinal ganglion cell degeneration via JNK3, Cell Death Differ, 2018, Apr; 25(4): 661-676 PMID: 29238071

Biological Activity

BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.53 mL 97.67 mL 195.34 mL
0.5 mM 3.91 mL 19.53 mL 39.07 mL
1 mM 1.95 mL 9.77 mL 19.53 mL
5 mM 0.39 mL 1.95 mL 3.91 mL

*The above data is based on the productmolecular weight 511.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12444
Actions Inhibitor
M. Wt 511.94
Formula C24H21ClF3NO4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 290315-45-6
Synonyms BMS 299897
SMILES C[[email protected]](C1=C(C=C(C=C1)F)CCCC(=O)O)N(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl

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