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Proteases

Items 51-100 of 1366

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Catalog No.
Product Name
Application
Product Information
Citations
  1. A12373
    Z-VAD-FMK

    Pan Caspase Inhibitor

    Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
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  2. A11985
    Amprenavir
    Amprenavir is an human immunodeficiency virus (HIV) protease inhibitor with IC50 of 14.6 ?? 12.5 ng/ml for wild-type HIV isolates
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  3. A14073
    Sivelestat sodium salt

    Neutrophil elastase inhibitor

    Sivelestat sodium salt is a selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. It inhibits NF-kB activation and LTB4-induced neutrophil transmigration in vitro.
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  4. A11336
    BMS-790052 2HCl

    NS5A inhibitor

    BMS-790052 is an NS5A inhibitor under investigation for the treatment of hepatitis C virus (HCV) infection.
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  5. A14100
    Nivocasan (GS-9450)

    Caspase inhibitor

    Nivocasan is a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models.
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  6. A10600
    MLN2238 (Ixazomib)

    Proteasome Inhibitor

    MLN2238 is a potent reversible and specific β5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM.
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  7. A13815
    FLI-06

    Gamma-secretase inhibitor

    FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A.
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  8. A10138
    BIBR 953 (Dabigatran, Pradaxa)

    Thrombin inhibitor

    BIBR 953 (Dabigatran, Pradaxa) is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate. It has shown antithrombotic efficacy in animal models of thrombosis, with a rapid onset of action and predictable pharmacodynamic response.

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  9. A13853
    Marizomib (NPI-0052, salinosporamide A)

    Proteasome Inhibitor

    Marizomib is a naturally-occurring salinosporamide, isolated from the marine actinomycete Salinospora tropica, with potential antineoplastic activity.
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  10. A13256
    CA-074

    Cathepsin B inhibitor

    CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.
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  11. A19622
    KP-457

    ADAM17 inhibitor

    KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC50s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively.
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  12. A10159
    BMS-790052 (Daclatasvir)

    HCV NS5A inhibitor

    BMS-790052 is an NS5A inhibitor under investigation for the treatment of hepatitis C virus (HCV) infection.
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  13. A10288
    DAPT (GSI-IX)

    Gamma secretase inhibitor

    DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.
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  14. A11332
    Boceprevir (SCH-503034)

    HCV Protease Inhibitor

    Boceprevir is a protease inhibitor used as a treatment for hepatitis C genotype 1.
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  15. A10980
    Cis-Lomibuvir (cis-VX-222)

    HCV Protease inhibitor

    VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection.
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  16. A11174
    YO-01027

    γ-secretase inhibitor

    YO-01027 is a dipeptidic γ-secretase inhibitor, an antiAlzheimer agent.
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  17. A15292
    ARP 100

    MMP-2 inhibitor

    ARP 100 is a selective inhibitor of matrix metalloproteinases 2 (MMP-2) with IC50 value of 12 nM.
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  18. A11901
    PMSF

    Serine/cysteine protease inhibitor

    PMSF is an irreversible serine/cysteine protease inhibitor.
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  19. A14263
    Aprotinin

    serine protease inhibitor

    Aprotinin is a small protein serine protease inhibitor, used to reduce perioperative blood loss and transfusion.
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  20. A10984
    VX-765 (Belnacasan)

    Caspase-1/4 inhibitor

    VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.
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  21. A11393
    E 2012

    gamma-secretase modulator

    E 2012 is γ-secretase inhibitor.
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  22. A10836
    Semagacestat (LY450139)

    Gamma-secretase inhibitor

    Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.
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  23. A13070
    LY573636 (Tasisulam)

    Apoptosis inducer

    LY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism.
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  24. A15300
    Ivachtin

    Caspase-3 inhibitor

    Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM).
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  25. A10617
    Nafamostat mesylate

    serine protease inhibitor

    Nafamostat is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.
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  26. A14377
    Sitagliptin

    DDP-4 inhibitor

    Sitagliptin is an oral antihyperglycemic (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class.
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  27. A11145
    CEP-18770 (Delanzomib)

    Proteasome inhibitor

    CEP-18770 is a novel orally active proteasome inhibitor with a favorable tumor selectivity profile for the treatment of MM and other malignancies responsive to proteasome inhibition.
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  28. A11194
    MK-0752

    Gamma-secretase inhibitor

    MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated.
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  29. A11201
    BMS-806 (BMS 378806)

    HIV Entry Inhibitor

    BMS-806, also known as BMS-378806 , is a type of medicine called an entry inhibitor. Entry inhibitors work by blocking HIV from entering human cells. BMS-378806 (BMS-806) is a small molecule that blocks the binding of host-cell CD4 with viral gp120 protein and therefore inhibits the first steps of HIV-1 infection.
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  30. A11212
    EP1013

    caspase inhibitor

    EP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes.
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  31. A11258
    Begacestat (GSI-953)

    γ-secretase inhibitor

    Begacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
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  32. A11259
    Nirogacestat (PF-03084014)

    γ-secretase inhibitor

    PF-03084014 is a reversible and selective inhibitor of γ-secretase with IC50 value of 6.2 nM .
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  33. A11265
    Odanacatib (MK-0822)

    Cathepsin K Inhibitor

    Odanacatib is an inhibitor of cathepsin K,an enzyme involved in bone resorption.
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  34. A11325
    BCX 1470 methanesulfonate

    Serine protease inhibitor

    BCX 1470 is serine protease inhibitor. BCX 1470 blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro.
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  35. A11331
    BCX 1470

    Serine protease inhibitor

    BCX 1470 is serine protease inhibitor. BCX 1470 blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro.
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  36. A11335
    Balapiravir (R1626)

    Polymerase inhibitor

    Balapiravir (R1626, RG1626) is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (R1479, RG1479).
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  37. A11337
    BMS 433796

    γ-Secretase Inhibitor

    BMS 433796 is a γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease.
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  38. A11345
    CTS-1027

    Matrix Metalloproteinase Inhibitor

    CTS-1027 is a potent MMP inhibitor that protects Against TNFα- and α-Fas-Induced liver Injury.
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  39. A11356
    BOC-D-FMK

    caspase inhibitor

    Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 ?M.
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  40. A11369
    CPA inhibitor

    CPA inhibitor

    CPA inhibitor is a potent inhibitor for carboxypeptidase A (CPA).
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  41. A11390
    DMP 777

    HLE inhibitor

    DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.
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  42. A11394
    Emricasan

    Caspase inhibitor

    Emricasan is a first-in-class caspase inhibitor in clinical trials for the treatment of liver diseases.
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  43. A11425
    gamma-secretase modulator 1

    Gamma-secretase modulator

    gamma-secretase modulator 1 is a gamma-secretase modulator, gamma-secretase modulator 1 is useful for Alzheimer's disease.
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  44. A11427
    gamma-secretase modulator 2

    Gamma-secretase modulator

    gamma-secretase modulator 2 is a potent and selective gamma-secretase modulator for treatment of Alzheimer's disease.
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  45. A11466
    Cathepsin Inhibitor 1

    Cathepsin Inhibitor

    Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.
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  46. A11470
    NSC 95397

    Phosphatase inhibitor

    NSC 95397 is a selective and effective dual-specificity, quinone-based phosphatase inhibitor.
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  47. A11499
    MLN4924 (HCL Salt)

    NAE Inhibitor

    NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival.
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  48. A11506
    Narlaprevir

    NS3 protease inhibitor

    Narlaprevir is a potent, selective, orally bioavailable NS3 protease inhibitor(Ki=6 nM; EC90=40 nM)
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  49. A11509
    NBD-557

    HIV-1 inhibitor

    NBD-557 is a potentially HIV-1 inhibitor.
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  50. A11510
    Nesbuvir

    HCV Polymerase Inhibitor

    HCV-796 is a selectively inhibitor of hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.
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  1. Akt2 1item
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