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Proteases

Items 51-100 of 1366

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Catalog No.
Product Name
Application
Product Information
Citations
  1. A12373
    Z-VAD-FMK

    Pan Caspase Inhibitor

    Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
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  2. A11985
    Amprenavir
    Amprenavir is an human immunodeficiency virus (HIV) protease inhibitor with IC50 of 14.6 ?? 12.5 ng/ml for wild-type HIV isolates
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  3. A14073
    Sivelestat sodium salt

    Neutrophil elastase inhibitor

    Sivelestat sodium salt is a selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. It inhibits NF-kB activation and LTB4-induced neutrophil transmigration in vitro.
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  4. A11336
    BMS-790052 2HCl

    NS5A inhibitor

    BMS-790052 is an NS5A inhibitor under investigation for the treatment of hepatitis C virus (HCV) infection.
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  5. A14100
    Nivocasan (GS-9450)

    Caspase inhibitor

    Nivocasan is a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models.
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  6. A10600
    MLN2238 (Ixazomib)

    Proteasome Inhibitor

    MLN2238 is a potent reversible and specific β5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM.
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  7. A13815
    FLI-06

    Gamma-secretase inhibitor

    FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A.
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  8. A10138
    BIBR 953 (Dabigatran, Pradaxa)

    Thrombin inhibitor

    BIBR 953 (Dabigatran, Pradaxa) is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate. It has shown antithrombotic efficacy in animal models of thrombosis, with a rapid onset of action and predictable pharmacodynamic response.

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  9. A13853
    Marizomib (NPI-0052, salinosporamide A)

    Proteasome Inhibitor

    Marizomib is a naturally-occurring salinosporamide, isolated from the marine actinomycete Salinospora tropica, with potential antineoplastic activity.
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  10. A13256
    CA-074

    Cathepsin B inhibitor

    CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.
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  11. A19622
    KP-457

    ADAM17 inhibitor

    KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC50s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively.
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  12. A10159
    BMS-790052 (Daclatasvir)

    HCV NS5A inhibitor

    BMS-790052 is an NS5A inhibitor under investigation for the treatment of hepatitis C virus (HCV) infection.
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  13. A10288
    DAPT (GSI-IX)

    Gamma secretase inhibitor

    DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.
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  14. A11332
    Boceprevir (SCH-503034)

    HCV Protease Inhibitor

    Boceprevir is a protease inhibitor used as a treatment for hepatitis C genotype 1.
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  15. A10980
    Cis-Lomibuvir (cis-VX-222)

    HCV Protease inhibitor

    VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection.
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  16. A11174
    YO-01027

    γ-secretase inhibitor

    YO-01027 is a dipeptidic γ-secretase inhibitor, an antiAlzheimer agent.
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  17. A15292
    ARP 100

    MMP-2 inhibitor

    ARP 100 is a selective inhibitor of matrix metalloproteinases 2 (MMP-2) with IC50 value of 12 nM.
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  18. A11901
    PMSF

    Serine/cysteine protease inhibitor

    PMSF is an irreversible serine/cysteine protease inhibitor.
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  19. A14263
    Aprotinin

    serine protease inhibitor

    Aprotinin is a small protein serine protease inhibitor, used to reduce perioperative blood loss and transfusion.
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  20. A10984
    VX-765 (Belnacasan)

    Caspase-1/4 inhibitor

    VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.
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  21. A10836
    Semagacestat (LY450139)

    Gamma-secretase inhibitor

    Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.
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  22. A11393
    E 2012

    gamma-secretase modulator

    E 2012 is γ-secretase inhibitor.
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  23. A13070
    LY573636 (Tasisulam)

    Apoptosis inducer

    LY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism.
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  24. A15300
    Ivachtin

    Caspase-3 inhibitor

    Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM).
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  25. A10617
    Nafamostat mesylate

    serine protease inhibitor

    Nafamostat is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.
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  26. A14377
    Sitagliptin

    DDP-4 inhibitor

    Sitagliptin is an oral antihyperglycemic (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class.
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  27. A10096
    Atazanavir sulfate (BMS-232632-05)

    HIV Protease inhibitor

    Atazanavir is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV).
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  28. A10097
    Atazanavir

    HIV Protease inhibitor

    Atazanavir is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV).
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  29. A10139
    BIBR-1048 (Dabigatran etexilate)

    Thrombin inhibitor

    BIBR-1048 (Dabigatran etexilate) is an anticoagulant from the class of the direct thrombin inhibitors.
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  30. A10157
    BMS-708163 (Avagacestat)

    Gamma-secretase inhibitor

    BMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis.
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  31. A10208
    CHR2797 (Tosedostat)

    Aminopeptidase inhibitor

    CHR-2797 (Tosedostat) is a novel metalloenzyme inhibitor that exerts antiproliferative effects against a range of tumor cell lines in vitro and in vivo and shows selectivity.
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  32. A10537
    Lopinavir (ABT-378)

    HIV Protease inhibitor

    Lopinavir is an inhibitor of the HIV protease.
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  33. A10602
    Ixazomib Citrate (MLN9708) Analogue

    Proteasome Inhibitor

    Ixazomib Citrate (MLN9708) Analogue is a proteasome inhibitor, which inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome.

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  34. A10732
    Pimecrolimus
    Pimecrolimus is a natural ascomycin macrolactam that binds to macrophilin-12 (FKBP-12) and inhibits calcineurin as well as prolyl isomerase (rotamase).
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  35. A10745
    Doxycycline HCl
    Doxycycline Hydrochloride is a synthetic tetracycline derivative with similar antimicrobial activity.
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  36. A10772
    Racecadotril (Acetorphan)
    Racecadotril is a potent enkephalinase inhibitor which exhibits selective antisecretory activity.
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  37. A10799
    Ritonavir

    HIV Protease inhibitor

    Ritonavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease.Ritonavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
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  38. A10848
    Sitagliptin phosphate monohydrate

    DDP-4 inhibitor

    Sitagliptin phosphate is an anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release , stimulates the insulin release and lowers blood glucose.
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  39. A10958
    Bestatin (Ubenimex)

    reversible Protease inhibitor

    Ubenimex, also known as NK 421 and Bestatin, is a CD13 inhibitor. Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism. Ubenimex synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma. Ubenimex inhibits cell proliferation, migration and invasion by inhibiting the expression of APN and inducing autophagic cell death in prostate cancer cells.
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  40. A21557
    ML132

    caspase 1 inhibitor

    ML132 (NCGC 00185682) is a potent and selective caspase 1 inhibitor with an IC50 of 0.316 nM.
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  41. A21558
    MK-0674

    cathepsin K inhibitor

    MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S.
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  42. A21566
    Gosogliptin

    DPP-IV inhibitor

    Gosogliptin is a potent and selective inhibitor of dipeptidyl peptidase-IV (DPP-IV).
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  43. A21573
    Dutogliptin

    DPP4 inhibitor

    Dutogliptin (PHX-1149 free base) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.
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  44. A21584
    Odiparcil

    indirect thrombin inhibitor

    Odiparcil (SB-424323) is indirect thrombin inhibitor that exerts its anticoagulant effect through activation of antithrombin II (heparin cofactor II) .
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  45. A21631
    PSI-7976

    HCV RNA replication inhibitor

    PSI-7976 is the isomer of PSI-7977. PSI-7977 is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
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  46. A21636
    Sofosbuvir impurity C

    HCV RNA replication inhibitor

    Sofosbuvir impurity C is the less active impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
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  47. A21641
    Sofosbuvir impurity A

    HCV RNA replication inhibitor

    Sofosbuvir impurity A, an diastereoisomer of sofosbuvir, is the impurity of sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.
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  48. A21656
    LCL521 dihydrochloride

    ACDase inhibitor

    LCL521 dihydrochloride (1,3DMG-B13 dihydrochloride) is an acid ceramidase (ACDase) inhibitor.
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  49. A21674
    KHK-IN-1 hydrochloride

    ketohexokinase (KHK) inhibitor

    KHK-IN-1 hydrochloride is a potent ketohexokinase (KHK) inhibitor with IC50 of 12 nM, interacts with Asp-27B in the ATP-binding region of KHK.
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  50. A21701
    (1S,2S,3R)-DT-061

    PP2A activator

    (1S,2S,3R)-DT-061 is an enantiomer of DT-061. DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
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  1. Inhibitor 1109items
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  4. Modulator 12items
  5. Inducer 2items
  6. Substrate 5items
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  1. Akt2 1item
  2. Akt3 1item