Catalog No.
Product Name
Application
Product Information
Citations
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Ligands for E3 Ligase
3-(4-Bromo-2-chlorophenyl)piperidine-2,6-dione is a ligand for the CRBN-type E3 ubiquitin ligase, facilitating targeted protein degradation via the PROTAC (proteolysis-targeting chimeras) approach. This compound can be employed in the development of novel therapeutics that harness the ubiquitin-proteasome system for selective removal of specific proteins. Its applications are significant in disease models where modulation of protein levels is desired for research and therapeutic purposes. -
Ligand for E3 Ligase
CRBN ligand-224 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC), allowing for targeted degradation of proteins in cellular systems. Its application is significant in drug discovery and development, particularly for modulating the activity of specific proteins involved in various diseases. -
Ligand for E3 Ligase
Desamino lenalidomide-pinacolborane is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand using a linker to create a PROTAC, enabling targeted protein degradation. Its applications extend to the study of ubiquitin-mediated pathways and drug development strategies aimed at modulating protein levels in various biological contexts. -
Ligand for E3 Ligase
Desamino lenalidomide-NO2 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in targeted protein degradation pathways. This compound can be conjugated to target protein ligands through a linker to design and develop PROTAC (proteolysis-targeting chimeras) molecules, enabling precise modulation of protein levels in research applications. Its utility in studying protein degradation mechanisms makes it a valuable tool for drug discovery and cancer research. -
E3 Ubiquitin Ligase Ligand
CRBN ligand-11 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating targeted protein degradation. This compound is instrumental in the synthesis of PROTACs (Proteolysis Targeting Chimeras), which are employed in cellular research to modulate protein levels and investigate the role of specific proteins in various biological processes. Its utility in drug discovery and development marks it as a significant tool for researchers exploring innovative therapeutic approaches. -
VHL Ligand
GNE7599 is a high-affinity von Hippel-Lindau (VHL) ligand, characterized by a dissociation constant (Kd) of 540 pM. This compound serves as a crucial component for the development of Proteolysis Targeting Chimeras (PROTACs), facilitating the targeted degradation of specific proteins. Its ability to bind with high specificity to VHL makes it an invaluable tool for research in targeted protein modulation and therapeutic applications in cancer and other diseases. -
Ligand for E3 Ligase
(R,S,S)-VH032 is a ligand for E3 ligase, specifically targeting the von Hippel-Lindau (VHL) protein. This compound inhibits the VHL/HIF-1α interaction and is pivotal in the synthesis of PROTACs. Notably, (R,S,S)-VH032 facilitates the development of tau-targeting small molecule PROTAC C004019, making it a valuable tool in research focused on targeted protein degradation and therapeutic applications. -
E3 ubiquitin ligase ligand
MS1262 is a selective ligand for the E3 ubiquitin ligase SPOP, targeting the SPOP substrate GLP. This compound facilitates the recruitment of SPOP and is utilized in research to study ubiquitination processes and related signaling pathways. MS1262 serves as a precursor for the synthesis of MS479, further expanding its utility in chemical biology investigations. -
E3 Ligase Ligand
Lenalidomide-F is an E3 ligase ligand that targets cereblon, facilitating the development of PROTAC molecules. It is specifically designed for use with LWY713, a potent degrader of FLT3, exhibiting a DC50 value of 0.64 nM. This compound selectively induces the degradation of FLT3 through proteasome-dependent mechanisms. Lenalidomide-F is valuable for research applications focused on targeted protein degradation and the therapeutic potential of PROTACs in oncology. -
Ligand for E3 Ligase
Glutarimide-(1-oxoisoindoline-5-carbaldehyde) functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the cereblon protein, enabling targeted protein degradation approaches. It can be conjugated with specific target protein ligands through a linker, making it suitable for the development of PROTACs in proteomics research and drug discovery applications. -
Ligand for E3 Ligase
Desamino lenalidomide-7-OH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon to target proteins. This compound can be utilized in the design of PROTACs by linking it to a target protein ligand via a suitable linker. Its biological activity enables selective modulation of protein levels, making it a valuable tool in targeted protein degradation research applications. -
Thalidomide Analog
2-(2,6-Dioxopiperidin-3-yl)-4-iodoisoindoline-1,3-dione is a Thalidomide analog that features an iodine substitution on the isoindoline structure. This compound exhibits significant biological activity related to anti-inflammatory and anti-angiogenic properties. It is primarily utilized in research applications investigating the mechanisms of action of Thalidomide and its derivatives in various therapeutic contexts, particularly in cancer and autoimmune disorders. -
Lenalidomide Derivative
Lenalidomide-4-Br-7-fluoro is a derivative of Lenalidomide featuring bromine and fluorine substituents on the benzyl ring. This compound exhibits immunomodulatory properties, enhancing immune responses and exhibiting anti-tumor activity. It can be utilized in research to investigate the mechanisms of action of Lenalidomide and its analogs, as well as their potential therapeutic applications in hematological malignancies. -
Ligands for E3 Ligase
1-(4-Pip-Ph)-DHP-dione is a ligand specifically designed for targeting E3 ligases. It plays a crucial role in the development of proteolysis-targeting chimeras (PROTACs), particularly in the synthesis of the HPK1 Degrader-2. This compound is valuable for research in targeted protein degradation and provides insights into E3 ligase-mediated cellular processes. -
Ligand for E3 Ligase
Desamino lenalidomide-5-COOH is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of cereblon to target proteins, enabling the formation of PROTACs (proteolysis-targeting chimeras) through a strategic linker attachment. Desamino lenalidomide-5-COOH is instrumental in studying targeted protein degradation pathways and has applications in drug discovery and therapeutic development. -
CRBN Ligand
N-Methylated pomalidomide acts as a selective ligand for cereblon (CRBN). This derivative of pomalidomide lacks the ability to recruit CRBN, making it a valuable negative control in studies involving pomalidomide. Additionally, N-methylated pomalidomide can be utilized in the synthesis of PROTACs, thereby assisting researchers in the exploration of targeted protein degradation pathways and mechanisms. -
Ligand for E3 Ligase
Desamino lenalidomide-6-OH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized in the synthesis of PROTACs by linking it to a target protein ligand through a suitable linker. Its applications include studies in targeted protein degradation and therapeutic strategies in cancer research. -
VHL Ligand
VH 101, thiol serves as a selective VHL ligand, primarily utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enables the targeted degradation of specific proteins by harnessing the ubiquitin-proteasome system, making it instrumental in drug discovery and therapeutic research. Its robust binding affinity and specificity towards VHL provide an effective tool for studies aimed at elucidating protein regulation mechanisms and developing novel treatments for various diseases. -
Ligand for E3 Ligase
CRBN ligand-395 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated with a target protein ligand using a linker to form a proteolysis-targeting chimera (PROTAC), enabling the targeted degradation of specific proteins. CRBN ligand-395 is valuable in research applications involving protein degradation and modulation of cellular pathways. -
Ligands for E3 Ligase
VH032-OH is a ligand for the E3 ligase Von Hippel-Lindau (VHL), enabling targeted protein degradation. This compound can be utilized in the development of PROTACs (Proteolysis Targeting Chimeras) by linking it to target proteins. VH032-OH facilitates the selective ubiquitination and subsequent proteasomal degradation of substrate proteins, making it a valuable tool for investigating protein turnover and cellular regulation in various research applications. -
Cereblon Ligand
E3 Ligase Ligand 56 is a specific ligand for the E3 ubiquitin ligase Cereblon, facilitating targeted protein degradation through proteolysis-targeting chimeras (PROTACs). This compound is instrumental in the synthesis of PROTAC CDK9 degrader-11, supporting research in targeted degradation mechanisms and their applications in cellular processes. Its utility in developing novel therapeutics makes it a valuable reagent for studies in oncology and pharmacology. -
Cereblon Binder
E3 Ligase Ligand 23 is a cereblon binder that facilitates the degradation of Ikaros and Aiolos through the ubiquitin-proteasome pathway. This compound is instrumental in probing the mechanisms of targeted protein degradation and the role of cereblon in modulating protein levels. It is valuable for research applications involving the regulation of immune responses and hematological malignancies. -
Ligand for E3 Ligase
Pomalidomide-6-OH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating targeted protein degradation through the proteolysis-targeting chimera (PROTAC) approach. This compound is instrumental in research applications focused on the selective modulation of protein levels within cellular contexts, contributing to studies in cancer and other diseases. Pomalidomide-6-OH serves as a valuable tool for investigating the biochemical pathways regulated by CRBN. -
Lenalidomide Analog
3-(7-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a Lenalidomide analog that serves as a valuable tool in PROTAC research. This compound selectively modulates protein degradation pathways, making it instrumental in the development of targeted therapeutics. Its structural similarity to Lenalidomide allows for the exploration of novel therapeutic applications in oncology and immunology. -
Ligand for E3 Ligase
CRBN ligand-788 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand via a linker, enabling the formation of a proteolysis-targeting chimeric (PROTAC) molecule. CRBN ligand-788 is primarily utilized in research focused on targeted protein degradation and harnessing the ubiquitin-proteasome system for therapeutic interventions. -
Ligand for E3 Ligase
Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride is a ligand targeting cereblon (CRBN) within the E3 ubiquitin ligase complex. This compound facilitates the recruitment of CRBN, making it a valuable tool for the development of PROTACs (proteolysis-targeting chimeras) through linker conjugation. It holds potential applications in research related to targeted protein degradation and the study of protein homeostasis in various diseases, particularly in cancer. -
Ligand for E3 Ligase
CRBN ligand-661 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the targeted recruitment of the cereblon protein. This compound is designed for use in the development of PROTACs (Proteolysis Targeting Chimeras), linking to specific target proteins to promote their degradation via the ubiquitin-proteasome pathway. Its potential applications include studies in targeted protein degradation and the modulation of protein levels in various biological contexts. -
Ligand for E3 Ligase
Desamino lenalidomide-COOH is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the targeted regulation of protein degradation. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera), enabling the selective modulation of protein functions in cellular and in vivo studies. It is a valuable tool for research applications in protein homeostasis and therapeutic development. -
Ligand for E3 Ligase
(S)-Thalidomide 4-fluoride is a selective ligand for the cereblon (CRBN) E3 ligase. This compound is utilized in the synthesis of DeDPP4, making it a valuable tool in research related to protein degradation and the development of targeted therapeutics. Its interaction with the E3 ligase pathway underscores its potential applications in cellular biology and drug discovery initiatives. -
Ligand for E3 Ligase
C5 Lenalidomide-CH3 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to generate a PROTAC, thereby enabling targeted protein degradation. Its unique mechanism offers valuable applications in research focused on protein modulation and degradation pathways. -
Ligand for E3 Ligase
Desamino lenalidomide-5-CO is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker to facilitate the formation of proteolysis-targeting chimeras (PROTACs). Its application in protein degradation studies makes it a valuable tool for exploring therapeutic strategies in various diseases, including cancer. -
Lenalidomide Analog
3-(7-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a Lenalidomide analog targeting the ubiquitin-proteasome system. This compound exhibits notable biological activity in the development of PROTACs (proteolysis-targeting chimeras), providing a valuable tool for research into targeted protein degradation. Its structural features enhance the potential for therapeutic applications in oncology and related fields. -
Thalidomide Analogue
Thalidomide-CH2NH2 hydrochloride is a Thalidomide analogue characterized by a primary amine functionality. This compound demonstrates potential biological activity by modulating immune responses and influencing angiogenesis. It is suitable for research applications investigating mechanisms of action related to inflammatory diseases, cancer treatment, and teratogenic effects associated with Thalidomide derivatives. -
Ligands for E3 Ligase
Thalidomide-pyrrolidine is a ligand for E3 ligases, facilitating targeted protein degradation via the PROTAC technology. This compound is instrumental in the synthesis of PROTAC ARD-1676, which enables selective modulation of protein levels in cellular systems. Thalidomide-pyrrolidine is valuable for research applications focused on therapeutic interventions in various diseases by leveraging the ubiquitin-proteasome pathway. -
Ligands for E3 Ligase
3-(4-Bromo-2-fluorophenyl)piperidine-2,6-dione is an effective ligand for the CRBN-type E3 ubiquitin ligase, facilitating targeted protein degradation through the formation of PROTACs (Proteolysis Targeting Chimeras). This compound is instrumental in studies focused on ubiquitin-mediated proteolysis and can be utilized in various research applications aimed at elucidating protein function and regulation. Its unique structural features enable specific binding interactions that are crucial for the development of innovative therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-617 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN to target proteins. This compound can be conjugated to a ligand that binds to a specific target protein through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). CRBN ligand-617 is applicable in studies focused on targeted protein degradation and has significant potential in drug discovery and therapeutic development. -
Ligands for E3 Ligase
E3 Ligase Ligand 18 is a selective ligand for E3 ubiquitin ligases, facilitating the targeted degradation of proteins through the ubiquitin-proteasome system. When conjugated to a target protein via a linker, it forms a PROTAC (proteolysis-targeting chimera), which effectively induces ubiquitination and subsequent degradation of cancer-associated proteins. This reagent is valuable in research focused on protein degradation pathways and may contribute to therapeutic strategies for cancer treatment. -
E3 Ligase Ligand
Thalidomide-(2)piperidine is a potent E3 ligase ligand that plays a critical role in targeted protein degradation. This compound is valuable for the synthesis of proteolysis-targeting chimeras (PROTACs), facilitating the selective degradation of proteins of interest in cellular models. Its unique mechanism of action makes it a powerful tool in chemical biology and drug discovery research. -
E3 Ligase Ligand
Thalidomide-pyrrolidine hydrochloride is an E3 ligase ligand that serves as a key building block for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates targeted protein degradation by engaging with E3 ligases, offering a valuable tool for studies in protein regulation and the development of novel therapeutic strategies. Its application in chemical biology makes it an important reagent for researchers exploring targeted degradation pathways. -
Ligands for E3 Ligase
Cereblon inhibitor 1 is an isoindoline derivative that functions as a modulator of cereblon E3 ubiquitin ligase. This compound is designed to inhibit cerablon activity, making it a valuable tool for cancer research by disrupting protein homeostasis and influencing cell signaling pathways. Its application may extend to studying the therapeutic potential of targeting E3 ligases in various cancer models. -
Ligands for E3 Ligase
Lenalidomide-4-aminomethyl hydrochloride is a derivative of Lenalidomide that functions as a ligand for cereblon (CRBN), a component of the E3 ubiquitin ligase complex. This compound facilitates the recruitment of CRBN protein, enabling targeted protein degradation. It can be utilized as a building block in the development of proteolysis-targeting chimeras (PROTACs) for various therapeutic applications in cancer research and other disease models. -
CRBN Ligand
CRBN ligand-9 is a selective ligand targeting cereblon (CRBN) with a binding affinity (Ki) of 8.9 μM. This compound is designed for use in the synthesis of PROTACs (proteolysis targeting chimeras), facilitating the targeted degradation of specific proteins. CRBN ligand-9 serves as an essential tool for research in drug discovery and development, particularly in studies focused on targeted protein degradation mechanisms. -
E3 Ligase Ligand
E3 Ligase Ligand 51 functions as a ligand for the E3 ligase CRBN, facilitating targeted protein degradation through the synthesis of PROTACs, specifically BTK Degrader-12. This compound plays a crucial role in the research of protein homeostasis, allowing for the selective degradation of target proteins. Its application is significant in the study of various diseases, including cancer, by modulating protein levels in cellular contexts. -
VHL Ligand Variants
SJF-0661 is a variant of the von Hippel-Lindau (VHL) protein ligand that lacks the capacity for targeted degradation. Serving as an essential control reagent, it is useful for studies involving VHL ubiquitin ligase ligands. This compound is synthesized by inverting the stereocenter of the critical hydroxyproline moiety in the original VHL ligand, allowing researchers to evaluate the specific activities of VHL ligands in various biological contexts. -
VHL Ligand
VL285 Phenol is a phenol-based analog of VL285, serving as a ligand for the E3 ubiquitin ligase VHL. This compound enables the synthesis of HaloPROTAC3, facilitating the degradation of HaloTag7 fusion proteins with an IC50 of 0.34 μM. It is a valuable tool for research applications involving targeted protein degradation and the study of protein homeostasis in cellular systems. -
CRBN Ligand
CRBN ligand-187 is a potent CRBN-type E3 ubiquitin ligase ligand that plays a crucial role in the modulation of ubiquitination processes. This compound has been utilized for the synthesis of TQ-3959, facilitating research in targeted protein degradation and cellular signaling pathways. Its ability to engage the CRBN ligase offers valuable insights for studies involving protein homeostasis and therapeutic interventions in various diseases. -
Ligand for E3 Ligase
CRBN ligand-789 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound is designed for use in the development of PROTACs (proteolysis-targeting chimeras) by enabling the targeted degradation of specific proteins when linked to a target protein ligand. Its application is significant in chemical biology and therapeutic research, providing a valuable tool for studying protein regulation and degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-774 is a ligand specifically designed for the E3 ubiquitin ligase cereblon (CRBN). It effectively recruits the cereblon protein and can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. This compound is instrumental in research applications focusing on targeted protein degradation and the modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-206 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN for targeted ubiquitination. This compound can be conjugated with a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimeras). CRBN ligand-206 is instrumental in studies aimed at regulating protein degradation pathways and understanding ubiquitin-mediated processes in cellular functions. -
Ligand for E3 Ligase
5-Fluoro-lenalidomide is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand using a linker to create a proteolysis-targeting chimera (PROTAC). Its ability to mediate targeted protein degradation makes it a valuable tool in the study of protein homeostasis and therapeutic development.
