Fig. 1 · Structure
Documents & Downloads
Pomalidomide-5-OH
Ligand for E3 Ligase
Pomalidomide-5-OH (5-hydroxy pomalidomide) serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN protein. This compound can be utilized in the synthesis of PROTACs by linking it to other ligands, enabling targeted protein degradation. Its applications in chemical biology and drug discovery make it an essential tool for researchers investigating proteostasis and therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1547162-41-3 |
| Applications | Ligand for E3 Ligase |
| Formula | C13H11N3O5 |
| Molecular Weight | 289.24 |
| Synonyms | 5-Hydroxy pomalidomide; CC-17368 |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(O)=C3N)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.