Fig. 1 · Structure
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Lenalidomide-F
E3 Ligase Ligand
Lenalidomide-F is an E3 ligase ligand that targets cereblon, facilitating the development of PROTAC molecules. It is specifically designed for use with LWY713, a potent degrader of FLT3, exhibiting a DC50 value of 0.64 nM. This compound selectively induces the degradation of FLT3 through proteasome-dependent mechanisms. Lenalidomide-F is valuable for research applications focused on targeted protein degradation and the therapeutic potential of PROTACs in oncology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2359705-88-5 |
| Applications | E3 Ligase Ligand |
| Formula | C13H11FN2O3 |
| Molecular Weight | 262.24 |
| SMILES | O=C(C(N(CC1=C2C=CC=C1F)C2=O)CC3)NC3=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.