Fig. 1 · Structure
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3-(4-Bromo-2-chlorophenyl)piperidine-2,6-dione
Ligands for E3 Ligase
3-(4-Bromo-2-chlorophenyl)piperidine-2,6-dione is a ligand for the CRBN-type E3 ubiquitin ligase, facilitating targeted protein degradation via the PROTAC (proteolysis-targeting chimeras) approach. This compound can be employed in the development of novel therapeutics that harness the ubiquitin-proteasome system for selective removal of specific proteins. Its applications are significant in disease models where modulation of protein levels is desired for research and therapeutic purposes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2923549-60-2 |
| Applications | Ligands for E3 Ligase |
| Formula | C11H9BrClNO2 |
| Molecular Weight | 302.55 |
| SMILES | O=C(C(C1=CC=C(Br)C=C1Cl)CC2)NC2=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.