CRBN ligand-224 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC), allowing for targeted degradation of proteins in cellular systems. Its application is significant in drug discovery and development, particularly for modulating the activity of specific proteins involved in various diseases.
CRBN ligand-224 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC), allowing for targeted degradation of proteins in cellular systems. Its application is significant in drug discovery and development, particularly for modulating the activity of specific proteins involved in various diseases.
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