Fig. 1 · Structure
Documents & Downloads
CRBN ligand-660
Ligand for E3 Ligase
CRBN ligand-660 is a ligand targeting the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to construct a proteolysis-targeting chimera (PROTAC), making it useful in studies involving targeted protein degradation and cellular protein modulation. Its application in research enables the exploration of new therapeutic strategies by harnessing the ubiquitin-proteasome system.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2154343-28-7 |
| Applications | Ligand for E3 Ligase |
| Formula | C12H10ClN3O3 |
| Molecular Weight | 279.68 |
| SMILES | O=C1NC(=O)C(N2C(=O)C3=CC(Cl)=NC=C3C2)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.