Fig. 1 · Structure
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E3 ligase Ligand 23
Cereblon Binder
E3 Ligase Ligand 23 is a cereblon binder that facilitates the degradation of Ikaros and Aiolos through the ubiquitin-proteasome pathway. This compound is instrumental in probing the mechanisms of targeted protein degradation and the role of cereblon in modulating protein levels. It is valuable for research applications involving the regulation of immune responses and hematological malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 444287-56-3 |
| Applications | Cereblon Binder |
| Formula | C20H17N3O4 |
| Molecular Weight | 363.37 |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCC4=CC=CC=C4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.