Fig. 1 · Structure
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N-Methylated pomalidomide
CRBN Ligand
N-Methylated pomalidomide acts as a selective ligand for cereblon (CRBN). This derivative of pomalidomide lacks the ability to recruit CRBN, making it a valuable negative control in studies involving pomalidomide. Additionally, N-methylated pomalidomide can be utilized in the synthesis of PROTACs, thereby assisting researchers in the exploration of targeted protein degradation pathways and mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1352827-50-9 |
| Applications | CRBN Ligand |
| Formula | C14H13N3O4 |
| Molecular Weight | 287.27 |
| Synonyms | Pomalidomide-methyl |
| SMILES | O=C1C2=C(C(N1C3C(N(C)C(CC3)=O)=O)=O)C(N)=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.