Fig. 1 · Structure
Documents & Downloads
CC-17369
Ligand for E3 Ligase
CC-17369 (7-Hydroxy pomalidomide) serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound, a metabolite of Pomalidomide, selectively recruits CRBN, making it a valuable tool in targeted protein degradation studies. CC-17369 can be conjugated to other ligands via a linker to create PROTACs, facilitating research into novel therapeutic strategies for diseases involving protein dysregulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1547162-46-8 |
| Applications | Ligand for E3 Ligase |
| Formula | C13H11N3O5 |
| Molecular Weight | 289.24 |
| Synonyms | 7-Hydroxy pomalidomide; Pomalidomide metabolite M16 |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C(O)=CC=C3N)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.