Fig. 1 · Structure
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VHL Ligand 14
VHL Ligand
VHL Ligand 14 is a specific ligand for the von Hippel-Lindau (VHL) protein, playing a crucial role in the development of PROTACs that target estrogen receptor α (ERα) for degradation. With a binding affinity of 196 nM, it facilitates the targeted ubiquitination and subsequent proteasomal degradation of ERα. This compound is primarily utilized in research applications focused on cancer biology and targeted protein degradation strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2010986-87-3 |
| Applications | VHL Ligand |
| Formula | C25H34N4O4S |
| Molecular Weight | 486.63 |
| SMILES | O=C([C@H]1N(C([C@@H](NC(C)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C2=CC=C(C3=C(C)N=CS3)C=C2)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.