Fig. 1 · Structure
Documents & Downloads
(R,S,S)-VH032
Ligand for E3 Ligase
(R,S,S)-VH032 is a ligand for E3 ligase, specifically targeting the von Hippel-Lindau (VHL) protein. This compound inhibits the VHL/HIF-1α interaction and is pivotal in the synthesis of PROTACs. Notably, (R,S,S)-VH032 facilitates the development of tau-targeting small molecule PROTAC C004019, making it a valuable tool in research focused on targeted protein degradation and therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2230826-33-0 |
| Applications | Ligand for E3 Ligase |
| Formula | C22H30N4O3S |
| Molecular Weight | 430.56 |
| SMILES | CC1=C(SC=N1)C(C=C2)=CC=C2CNC([C@@H]3N(C[C@H](C3)O)C([C@@H](N)C(C)(C)C)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.