Fig. 1 · Structure
Documents & Downloads
CRBN ligand-11
E3 Ubiquitin Ligase Ligand
CRBN ligand-11 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating targeted protein degradation. This compound is instrumental in the synthesis of PROTACs (Proteolysis Targeting Chimeras), which are employed in cellular research to modulate protein levels and investigate the role of specific proteins in various biological processes. Its utility in drug discovery and development marks it as a significant tool for researchers exploring innovative therapeutic approaches.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2962967-27-5 |
| Applications | E3 Ubiquitin Ligase Ligand |
| Formula | C11H10BrFN2O2 |
| Molecular Weight | 301.11 |
| SMILES | O=C(C(NC1=CC=C(Br)C(F)=C1)CC2)NC2=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.