Fig. 1 · Structure
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Hydrouracil-3-Ph-COOH
Cat. No.
A80498
CAS
2377644-59-0
Ligand for E3 Ligase
Hydrouracil-3-Ph-COOH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in biochemical applications. This compound is designed to be employed in the development of proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands through a suitable linker, making it valuable in targeted protein degradation research. Its utility in creating complex biologics underscores its significance in advancing studies of protein modulation and therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2377644-59-0 |
| Applications | Ligand for E3 Ligase |
| Formula | C11H10N2O4 |
| Molecular Weight | 234.21 |
| SMILES | O=C(O)C1=CC=CC(=C1)N2C(=O)NC(=O)CC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.