Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
3-Hydroxyazetidine-Cyclohexanol serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras. Its chemical structure is designed to enhance the efficacy of targeted protein degradation, making it a valuable tool in drug discovery and development research. This compound is instrumental in the synthesis of ALK PROTACs, contributing to advancements in targeted therapies for various cancers. -
PROTAC Linker
Benzyl-PEG8-THP is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound promotes the targeted degradation of specific proteins through an E3 ubiquitin ligase-mediated pathway. Its application is essential in drug discovery and development for creating novel therapeutics that modulate protein levels in a highly selective manner. -
PROTAC Linker
Ald-Ph-amido-C2-PEG3-NH-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the development of targeted protein degradation systems by connecting target proteins to E3 ligases. It enhances selectivity and efficiency in protein degradation studies, making it a valuable tool for research in targeted therapeutics and cellular pathways. -
PROTAC linker
Hydroxy-Amino-bis(PEG2-propargyl) serves as a PEG-based PROTAC linker, facilitating the design of proteolysis-targeting chimeras (PROTACs). This versatile compound features an alkyne moiety, enabling its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its application in research supports the development of targeted protein degradation strategies, enhancing the exploration of protein functions and therapeutic interventions. -
PROTAC Linkers
Thiol-C9-PEG4-acid is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the conjugation of target proteins to E3 ligases, enhancing the degradation of selected proteins within cellular systems. This compound is essential for researchers exploring targeted protein degradation and related therapeutic modalities in various biological contexts. -
PROTAC Linkers
CHO-CH2-PEG1-CH2-Boc is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the development of bifunctional molecules that promote targeted degradation of specific proteins, enabling innovative therapeutic strategies. Its hydrophilic nature enhances solubility, making it suitable for various biological applications in chemical biology and medicinal chemistry research. -
PROTAC Linker
Azide-PEG7-Tos is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules. Its versatility in click chemistry expands the potential for targeted protein degradation studies, making it an essential tool for researchers in areas such as drug discovery and targeted therapy development. -
PROTAC Linkers
Bromo-PEG4-NHS ester is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligase recruiting components, enhancing the efficacy of targeted protein degradation. Its versatile chemical properties make it suitable for various applications in chemical biology research, particularly in the development of novel therapeutics focusing on selective protein modulation. -
PROTAC Linkers
Hydroxy-PEG12-Boc is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its primary mechanism involves facilitating the conjugation of target proteins to E3 ligases, thereby promoting targeted degradation pathways. Hydroxy-PEG12-Boc enhances cellular permeability and solubility of PROTACs, making it essential for studies in targeted protein degradation and cellular biotechnology research. -
PROTAC Linker
Azido-PEG3-phosphonic acid ethyl ester is a PEG-based linker designed for PROTAC synthesis, targeting the ubiquitin-proteasome system to facilitate protein degradation. This compound features an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules that possess DBCO or BCN groups, making it a valuable tool for developing targeted protein degradation strategies in chemical biology research. -
PROTAC Linkers
Azido-PEG8-C1-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds. Its versatility in click chemistry makes it an invaluable tool for researchers focused on targeted protein degradation and biochemical studies. -
PROTAC Linkers
Benzyl-PEG9-Ots is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis-targeting chimeras). This compound facilitates targeted protein degradation by linking E3 ligase adapters to a specific protein of interest. Its application in PROTAC development enables advancements in cellular research and therapeutic strategies by modulating protein levels within biological systems. -
PROTAC Linker
Ms-PEG12-m is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This versatile linker facilitates the conjugation of target proteins and E3 ligase moieties, enhancing the pharmacological properties of PROTAC candidates. It is valuable in chemical biology research focused on targeted protein degradation and therapeutic development. -
PROTAC Linkers
m-PEG6-C6-phosphonic acid ethyl ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of bifunctional molecules that induce targeted protein degradation through the ubiquitin-proteasome pathway. Its unique structural properties enable efficient conjugation and enhanced solubility, making it suitable for advancing research in targeted therapeutic strategies and drug development. -
PROTAC Linkers
m-PEG4-CH2-methyl ester is a polyethylene glycol (PEG) and alkyl/ester-based PROTAC linker that serves as a crucial component in the synthesis of PROTAC molecules. This versatile linker enhances the solubility and pharmacokinetic properties of the resultant PROTACs. It is primarily utilized in drug discovery and development research, particularly for targeted protein degradation applications. -
PROTAC Linker
Azido-PEG1-methyl ester is a versatile PROTAC linker featuring an azide moiety, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This reagent is a valuable tool in click chemistry, capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing and DBCO or BCN-modified molecules, respectively. Its application enhances the development of targeted protein degradation strategies in chemical biology and drug discovery. -
PROTAC Linker
Methylamino-PEG5-azide is a PEG-based linker designed for use in PROTAC synthesis, targeting protein degradation pathways. Featuring an azide moiety, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalities. This versatile reagent is essential for the development of novel PROTAC compounds, facilitating targeted protein degradation research and applications in drug discovery. -
PROTAC Linker
Azido-PEG8-C-Boc is a PEG-based linker designed for the synthesis of PROTACs, targeting targeted protein degradation pathways. This compound features an azide functional group, enabling the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne-containing molecules, as well as the strain-promoted alkyne-azide cycloaddition (SPAAC) reaction with DBCO or BCN-modified substrates. Its applications are vital in the development of innovative therapeutic strategies in chemical biology and drug discovery. -
PROTAC Linkers
Tetrahydropyranyldiethyleneglycol is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the creation of bifunctional molecules that efficiently induce targeted degradation of specific proteins, enabling researchers to investigate protein function and therapeutic interventions. It is an essential tool in drug discovery and development, particularly for studies focused on targeted protein degradation pathways. -
PROTAC Linkers
Bis-(m-PEG4)-amidohexanoic acid is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound enables the formation of stable and efficient PROTACs, facilitating the selective degradation of target proteins. It serves as a crucial tool in drug development and molecular biology research, particularly for studying protein interactions and the modulation of cellular pathways. -
PROTAC Linker
N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) is a PEG-based linker designed for use in the synthesis of PROTAC molecules. Functioning as a click chemistry reagent, it features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized molecules, facilitating the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
Bis-acrylate-PEG5 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling targeted degradation through the ubiquitin-proteasome system. Bis-acrylate-PEG5 is instrumental in advancing research in targeted protein degradation and therapeutic development. -
PROTAC linker
Pyrene-PEG2-azide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an azide functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with DBCO or BCN groups. This reagent is essential for the development of targeted protein degradation strategies and offers versatility in chemical biology applications. -
Linker
C1-BCEA-Acm is a chemical linker utilized for the synthesis of polyubiquitin chains and ubiquitin-modified substrates. It facilitates the attachment of ubiquitin moieties, thereby allowing for the study of ubiquitination processes in various biological contexts. This reagent is essential for researchers investigating protein degradation, cellular signaling, and related pathways involving ubiquitin signaling. -
PROTAC Linker
Carboxy-PEG4-sulfonic acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a carboxylic acid functional group that enhances solubility and facilitates conjugation, making it ideal for generating bifunctional compounds that promote targeted protein degradation. Its application in PROTAC development enables researchers to explore novel therapeutic strategies by selectively modulating protein levels in cellular environments. -
PROTAC Linker
Ph-PEG3 is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the conjugation of target proteins to E3 ligases, promoting targeted degradation of specific proteins within cellular systems. This compound is instrumental in the development of PROTAC-based therapies aimed at modulating protein levels for research applications in drug discovery and disease treatment. -
PROTAC Linker
N-Ethylpropionamide-PEG1-Br is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the selective degradation of target proteins through the recruitment of the E3 ubiquitin ligase, enhancing cellular clearance of unwanted proteins. It serves as a valuable tool for researchers investigating targeted protein degradation and the development of novel therapeutic strategies. -
PROTAC Linkers
Mal-PEG10-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins, enhancing the selective degradation of specific proteins via the ubiquitin-proteasome system. Its utility in PROTAC development makes it a valuable tool for researchers studying protein turnover and targeted protein degradation mechanisms. -
PROTAC Linker
Boc-NH-PEG7-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of targeting ligands to E3 ligases, enhancing the efficacy of targeted protein degradation pathways. Its favorable biocompatibility and linker flexibility make it ideal for various applications in drug discovery and molecular biology research. -
PROTAC Linkers
Azido-PEG11-acid is a PEG-based linker designed for Protein-Targeting Chimera (PROTAC) synthesis. Featuring an azide functional group, it readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds and can also engage in strain-promoted azide-alkyne cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) moieties. This versatile linker is valuable for researchers focused on targeted protein degradation and therapeutic development. -
PROTAC Linker
N-(m-PEG4)-N'-(PEG4-NHS ester)-Cy5 is a PEG-based PROTAC linker designed for efficient protein degradation applications. This compound facilitates the synthesis of PROTACs, enabling targeted degradation of specific proteins through the ubiquitin-proteasome system. Its fluorogenic properties allow for specific detection and tracking in cellular assays, making it an essential tool for researchers investigating targeted protein modulation. -
PROTAC Linkers
Acid-PEG5-TEMPO is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling selective degradation of specific proteins within cellular environments. Its application in PROTAC development provides a powerful tool for researchers exploring protein modulation and therapeutic strategies in various disease models. -
PROTAC Linker
Propargyl-PEG3-Boc is a polyethylene glycol (PEG)-based linker designed for PROTAC synthesis. It features an alkyne group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing compounds. This compound facilitates the development of targeted protein degradation strategies, making it a valuable tool in chemical biology and therapeutic research applications. -
PROTAC Linker
3-Aminophenol-PEG4-methyl is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted degradation mechanisms. Its application in PROTAC development supports studies in protein regulation, therapeutic target identification, and the investigation of protein-homeostasis-related disorders. -
PROTAC Linker
Propargyl-PEG4-5-nitrophenyl carbonate is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its alkyne functionality allows for participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the conjugation of azide-containing molecules. This compound supports various applications in targeted protein degradation research, enabling the development of innovative therapeutic strategies. -
PROTAC Linker
Bis-PEG4-sulfonic acid is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It facilitates the conjugation of target proteins with E3 ligases, enhancing the recruitment and degradation of specific proteins in cellular systems. This compound is instrumental in developing novel therapeutic strategies for targeted protein degradation in cancer and other diseases. -
PROTAC Linker
Tos-aminoxy-Boc-PEG4-Tos is a PEG-based linker specifically designed for PROTAC (proteolysis-targeting chimera) applications. This compound facilitates the synthesis of PROTACs by enabling the conjugation of target proteins with E3 ligases, thus promoting targeted degradation pathways. Its unique structure enhances solubility and stability, making it a valuable tool for researchers investigating protein regulation mechanisms and drug discovery processes. -
PROTAC Linker
m-PEG7-azide serves as a versatile PEG-based linker for the synthesis of PROTACs, functioning through its azide group. This reagent is effective in click chemistry, specifically participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can facilitate strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) functionalized compounds. This makes m-PEG7-azide a valuable tool for advancing targeted protein degradation research. -
PROTAC Linkers
BOC-NH-PEG2-propene is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the creation of bifunctional molecules that engage target proteins for ubiquitination and degradation. Its flexible structure enhances solubility and biocompatibility, making it suitable for various applications in targeted protein degradation research. -
PROTAC Linker
Biotin-PEG2-NH-Boc is a PEG-based PROTAC linker that incorporates a biotin label for easy detection and affinity purification. This compound plays a crucial role in the design and synthesis of Proteolysis Targeting Chimeras (PROTACs), facilitating targeted protein degradation. Its unique structure allows for enhanced solubility and stability, making it suitable for a variety of biochemical assays and research applications aimed at modulating protein levels in cellular contexts. -
PROTAC Linker
N-Mal-N-bis(PEG2-C2-Boc) is a polyethylene glycol (PEG)-derived PROTAC linker that facilitates the synthesis of proteolysis targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, enabling more efficient target protein degradation. Key applications include drug development and targeted protein modulation in cellular research. -
PROTAC Linker
Ald-CH2-PEG5-Boc is a polyethylene glycol (PEG) and alkyl/ether-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This linker facilitates the conjugation of targeting ligands to E3 ligases, enabling the selective degradation of specific proteins within cellular systems. It plays a crucial role in chemical biology and drug discovery research focused on ubiquitin-proteasome pathways and targeted protein degradation. -
PROTAC Linker
2-[4-(Aminomethyl)triazol-1-yl]ethanamine is a specialized PROTAC linker that serves as a crucial component in targeted protein degradation strategies. This compound facilitates the synthesis of PROTAC CB1R Degrader-1, enabling the effective modulation of cannabinoid receptor 1 (CB1R) levels. Its application in research supports investigations into protein homeostasis and therapeutic approaches for various diseases. -
PROTAC Linkers
Piperidine-C-piperidine-Boc is a PROTAC linker known for its role in targeted protein degradation, specifically in the design of CDK2 degrader 2. This compound facilitates the selective ubiquitination and subsequent proteasomal degradation of target proteins, making it essential for research in cancer biology and therapeutic development. Its unique structure enables researchers to explore novel therapeutic avenues through the modulation of protein levels in various biological contexts. -
PROTAC Linker
N-Benzyl-N-bis-PEG4 is a PEG-based linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective recruitment of E3 ligases, enhancing the targeted degradation of specific proteins within cellular environments. It is a valuable tool for researchers investigating targeted protein degradation and its applications in drug discovery and molecular biology. -
PROTAC Linkers
CH2COOH-PEG9-CH2COOH is a PEG-based linker specifically designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enabling targeted protein degradation. Its unique structure supports improved solubility and flexibility, enhancing the efficacy of PROTAC strategies in chemical biology research. -
PROTAC Linker
Hydroxy-PEG3-PFP ester is a polyethylene glycol (PEG)-based PROTAC linker that facilitates the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances solubility and biocompatibility, making it a valuable tool in the development of targeted protein degradation methodologies. Hydroxy-PEG3-PFP ester is particularly useful for research applications involving targeted therapy and the modulation of protein levels within cellular systems. -
PROTAC Linker
(3R,4R)-3-Methyl-4-piperidinol serves as a PROTAC linker, facilitating the targeted degradation of proteins through the proteasome pathway. This compound is essential in the synthesis of innovative PROTAC molecules, such as the BCL6 Degrader-3. Its application in chemical biology aids in studying protein interactions and degradation mechanisms, contributing significantly to drug discovery research. -
PROTAC Linker
[10-(Diethoxy-phosphoryl)-decyl]-phosphonic acid is a versatile alkyl chain-based linker designed for PROTAC (Proteolysis Targeting Chimeras) development. Its unique chemical structure enables efficient conjugation to target proteins, facilitating the targeted degradation of specific cellular proteins. This compound serves as a critical building block in the synthesis of PROTACs, aiding in the advancement of therapeutic strategies in drug discovery and cellular biology research. -
PROTAC Linker
Benzyl-PEG2-acid is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis targeting chimera) synthesis. This compound serves as a crucial component that enhances the solubility and stability of PROTAC molecules. Its incorporation into PROTAC development supports targeted protein degradation studies and facilitates the investigation of cellular signaling pathways.
